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Перегляд Вiopolymers and Cell, 2019, vol. 35 за датою випуску

Репозиторій DSpace/Manakin

Перегляд Вiopolymers and Cell, 2019, vol. 35 за датою випуску

Сортувати за: Порядок: Результатів:

  • Expression of ITSN2 and TKS5 in different subtypes of breast cancer tumors 
    Kropyvko, S.V.; Tsyba, L.O.; Novokhatska, O.V.; Nemesh, Y.M.; Syvak, L.A.; Tarasenko, T.Ye.; Grabovoy, A.N.; Rynditch, A.V. (Вiopolymers and Cell, 2019)
    Aim. Regardless a great progress in treatment, 15% of breast cancer cases remain lethal. One of the main problems in diagnosis and cure of this cancer type is its high clinical and genetic heterogeneity, and the identification ...
  • Unrepairable substrates of nucleotide excision repair and their application to suppress the activity of this repair system 
    Popov, A.A.; Evdokimov, A.N.; Lukyanchikova, N.V.; Petruseva, I.O.; Lavrik, O.I. (Вiopolymers and Cell, 2019)
    In the previous studies, the DNA with the bulky Fap-dC derivative was demonstrated to be a difficult substrate for the nucleotide excision repair (NER), a system which is involved in the removal of bulky lesions from DNA. ...
  • Crambe aspera plants in vitro propagation and its effect on fatty acids and phenolic compounds content and genome stability 
    Pushkarova, N.O.; Lakhneko, O.R.; Morgun, B.V.; Kuchuk, M.V.; Blume, Ya.B.; Yemets, A.I. (Вiopolymers and Cell, 2019)
    In vitro culture can be used for endangered species preservation but its effect on biochemical properties and genetic stability of plants requires further research. Aim. The study on fatty acids content, phenolic compounds ...
  • Aggregation of erythrocytes: a novel activity of HBD-2 
    Semeniuk, D.O.; Starenka, I.O.; Pogribna, A.P.; Sokol, I.V.; Govsieiev, D.O. (Вiopolymers and Cell, 2019)
    Aim. To investigate an ability of HBD-2 to induce aggregation of erythrocytes. Methods. Aggregation assay, turbidimetry, light microscopy. Results. We have identified aggregation of erythrocytes in presence of at least ...
  • Use of lectins as vector molecules for delivery of drugs to cells and tissues. Report 2. 
    Antonyuk, V.O.; Skorohyd, N.R.; Lozynskyi, A.V.; Antonyuk, R.V.; Lesyk, R.B.; Stoika, R.S. (Вiopolymers and Cell, 2019)
    Aim.To determine cytotoxic effects towards a tumor cells culture of the heterocyclic derivative conjugated with lectins of different carbohydrate specificity. Methods. Conjugation of lectins (Pea seeds (PSA), peanuts (PNA) ...
  • Phylogenetic analysis of two Ukrainian isolates of Wheat streak mosaic virus 
    Mishchenko, L.T.; Dunich, A.A.; Skrypkina, I.Ya.; Kozub, N.O. (Вiopolymers and Cell, 2019)
    The study of molecular characteristics and, in particular, the nucleotide (nt) and amino acid (aa) sequences of the viral genomes, is necessary to know the changes in their geographical range, phylogenetic relationships, ...
  • Hit identification of FGFR1 inhibitors using receptor-based virtual screening 
    Tarnavskiy, S.S.; Protopopov, M.V.; Borovykov, O.V.; Pryhodko, A.O.; Bdzhola, V.G.; Yarmoluk, S.M. (Вiopolymers and Cell, 2019)
    Aim. To identify novel FGFR1 inhibitors using the virtual screening approach. Methods. Virtual screening of a small organic compounds library was performed by molecular docking using the Autodock 4.2.6 program package. The ...
  • Scaffold proteins ITSN1 and ITSN2 interact with nuclear RNA-binding proteins 
    Pankivskyi, S.V.; Senchenko, N.V.; Busko, P.B.; Rynditch, A.V. (Вiopolymers and Cell, 2019)
    Aim. To identify novel ITSN1 and ITSN2 partners among RNA-binding proteins (RBPs) involved in regulation of mRNA processing. Methods. GST pull-down, immunoprecipitation assays and bioinformatics analysis was used to identify ...
  • Hydrogen sulfide and mitochondria 
    Gerush, I.V.; Ferenchuk, Ye.O. (Вiopolymers and Cell, 2019)
    There are different opinions about the role of hydrogen sulfide (H2S) in catalytic and energy processes, but the biochemistry of all possible effects of H2S is not well studied yet. The enzymatic synthesis of H2S is catalyzed ...
  • The STAT5 transcription factor in B-cells of patients with chronic lymphocytic leukemia 
    Matvieieva, A.S.; Kovalevska, L.M.; Ivanivska, T.S.; Klein, E.; Kashuba, E.V. (Вiopolymers and Cell, 2019)
    Aim. To find out the cause of inhibition of the IL2-STAT5 signaling pathway in chronic lymphocytic leukemia (CLL) cells. Methods.CLL cells were isolated from peripheral blood, using gradient centrifugation on a ficoll-verografin ...
  • Expression of cancer-associated genes in prostate tumors at mRNA and protein levels 
    Gerashchenko, G.V.; Grygoruk, O.V.; Rosenberg, E.E.; Bondarenko, Yu.M.; Kashuba, E.V.; Kashuba, V.I. (Вiopolymers and Cell, 2019)
    Aim. To analyze an expression pattern of the cancer-associated genes in prostate tumors at mRNA and protein levels and find putative association between the expression of these genes and the genes, controlling epithelial ...
  • Identification of 4‐methoxythieno[2,3‐d]pyrimidines as FGFR1 Inhibitors 
    Kotey, I.M.; Protopopov, M.V.; Starosyla, S.A.; Balanda, A.O.; Pletnova, L.V.; Prykhod'ko, A.O.; Bdzhola, V.G.; Yarmoluk, S.M. (Вiopolymers and Cell, 2019)
    Aim. To identify novel FGFR1 inhibitors using virtual screening approach. Methods. We used methods of organic synthesis, molecular docking via the Autodock 4.2.6 program package and in vitro biochemical tests with γ-32P. ...
  • Spectroscopic study of binding of a cationic Pheophorbide-a to an antiparallel quadruplex Tel22 
    Ryazanova, O.A.; Zozulya, V.N.; Voloshin, I.M.; Glamazda, A.Yu.; Dubey, I.Ya.; Dubey, L.V.; Karachevtsev, V.A. (Вiopolymers and Cell, 2019)
    Aim. To study the binding of a water-soluble cationic Pheophorbide-a derivative (CatPheo-a) ta a Na+–stabilized antiparallel quadruplex formed by 22-mer oligonucleotide d[AG3(T2AG3)3] of the human DNA telomeric sequence ...
  • Identification of a novel S6K1 splice variant coding for the p60-S6K1 isoform 
    Zaiets, I.V.; Holiar, V.V.; Filonenko, V.V. (Вiopolymers and Cell, 2019)
    Aim. To identify a splicing mRNA of S6K1 kinase specific for the p60-S6K1 isoform alone. Methods. RT-PCR, DNA sequencing, Western blotting. Results. RT-PCR analysis of total RNA extracted from MCF-7 cells and subsequent ...
  • Optimization of nucleosome assembly from histones and model DNAs and estimation of the reconstitution efficiency 
    Kutuzov, M.M.; Kurgina, T.A.; Belousova, E.A.; Khodyreva, S.N.; Lavrik, O.I. (Вiopolymers and Cell, 2019)
    Nucleosome core particles (NCPs) are basic units of chromatin organization; they represent the most convenient model system for the study of key DNA-dependent processes. Therefore, a robust method of nucleosome assembly ...

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