It is a matter of common knowledge, that «core» 2'-5'-oligoadenylates and their analogues posses broader biological activity than it can be predicted within the traditional «interferon» hypothesis. They exhibit immunomodulatory ...

Disruption of the genetic component of cells are mandatory element of malignant transformation. For the majority of blood neoplasias genetic disorders have been discovered, and they can be used for diagnosis and appropriate ...

This review outlines the major features and distinctions of cell populations, types and directions of selection in such populations. Population-genetic basis for cell adaptation to growth conditions in vitro is elucidated; ...

We have designed and offered a comprehensive approach to solving several problems in modern agriculture and human health. It is based on the original use of biotechnology. The mechanisms of alkylation of amines, nucleic ...

In prokaryotic cells three tRNA species, tRNASer, tRNALeu and tRNATyr, possess a long variable arm of 11–20 nucleotides (type 2 tRNA) rather than usual 4 or 5 nucleotides (type 1 tRNA). In this review we have summarized ...

Results of investigations on the development of new regulators of functional activity of nucleic acid biosynthesis enzymes based on polycyclic nitrogen-containing heterosystems are summarized. Computer design and molecular ...