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періодичних видань НАН України
періодичних видань НАН України
Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats
Репозиторій DSpace/Manakin
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Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats
Тема:
Original contributions
Посилання:
Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats / D. Herrera-Covarrubias, G.A. Coria-Avila, X.P. Chavarra, C. Fernndez-Pomares, J. Manzo, G.E. Aranda-Abreu, M.E. Hernndez // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 13-18. — Бібліогр.: 47 назв. — англ.
Підтримка:
This study was supported by the Mexican Council for Science and Technology (CONACyT) to DHC (No. 35258), to MEHA (No. 106531) and by academic group UV-CA-304 (Neuroquímica) from the Center for Brain Research, University of Veracruz. The authors want to give special thanks to MVZ Esp. Juan Rosales Raya for his assistance with the histological descriptions.
Дата:
2015
Переглядів:
738
Завантажень:
498
Анотація:
Evidence indicates that prolactin plays a crucial role in the normal function and development of the prostate, but abnormal high levels of the hormone are associated with hyperplasia and cancer of the gland. Aims: The present study was designed to describe the progressive specific histological abnormalities in the prostate of rats with chronic hyperprolactinemia. Material and Methods: Prolactin was administered during 4; 12 or 24 weeks, and the resulting prostatic alterations were compared with control rats, and also with those treated with testosterone, or the combination of prolactin + testosterone. Results: Rats treated with prolactin, testosterone or prolactin + testosterone expressed precancerous histological abnormalities in the dorsolateral and ventral portions of the prostate as early as in 4 weeks of treatment, but in all cases the malignancy increased after 12 or 24 weeks of treatment. Conclusion: Our study confirms that chronic hyperprolactinemia is a cause of prostate precancerous pathologies. Key Words: prolactin, prostate, cancer, dysplasia, testosterone.
