Наукова електронна бібліотека
періодичних видань НАН України
періодичних видань НАН України
Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment
Репозиторій DSpace/Manakin
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Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment
Тема:
Original contributions
Посилання:
Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment / D. Subramanyam, K.C.V. Subbaiah, W. Rajendra, V. Lokanatha // Experimental oncology. — 2013. — Т. 35, № 2. — С. 97-100. — Бібліогр.: 30 назв. — англ.
Підтримка:
The authors are thankful to Dr. D.S. Raju Naidu and Dr. P. Chandra Sekharan for providing cervical cancer samples. The authors also thanks to Institutional Ethical committee (IEC), S.V. Medical College, for providing ethical clearance and UGC-BSR-Non-SAP for providing financial assistance.
Дата:
2013
Переглядів:
400
Завантажень:
234
Анотація:
Aim - in the present study, the effect of chemo and radio therapies on serum trace elements content and antioxidant activity in blood serum of cervical cancer patients was evaluated. Among 104 cervical cancer patients selected for the present study, 54 and 50 patients were treated with chemo- and radiotherapy respectively. Plasma Se, Zn, Cu and some enzymatic antioxidants activities were estimated in serum before and after the treatment. The decreased levels of serum trace elements, glutathione peroxidase activity and total antioxidant capacity, and increased malondialdehyde, glutathion reductase was observed in cervical cancer patients when compared to healthy controls. The increased concentration of serum Se, Zn was observed in patients treated with chemotherapy. Simultaneously there was a significant (P << 0,001) increase in glutathione peroxidase and total antioxidant capacity, and significant decrease (P << 0,05) in malondialdehyde and glutathion reductase levels in the serum of patients treated with chemotherapy compared to the patients treated with radiotherapy.
