Наукова електронна бібліотека
періодичних видань НАН України
періодичних видань НАН України
Sensitivity of human laryngeal squamous cell carcinoma Hep-2 to metrotexate chemoterapy
Репозиторій DSpace/Manakin
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| dc.contributor.author | Galbiatti, A.L.S. | |
| dc.contributor.author | Caldas, H.C. | |
| dc.contributor.author | Padovani Junior, J.A. | |
| dc.contributor.author | Pavarino, E.C. | |
| dc.contributor.author | Goloni-Bertollo, E.M. | |
| dc.date.accessioned | 2018-06-21T12:37:44Z | |
| dc.date.available | 2018-06-21T12:37:44Z | |
| dc.date.issued | 2012 | |
| dc.identifier.citation | Sensitivity of human laryngeal squamous cell carcinoma Hep-2 to metrotexate chemoterapy / A.L.S. Galbiatti, H.C. Caldas, J.A. Padovani Junior, E.C. Pavarino, E.M. Goloni-Bertollo // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 367-369. — Бібліогр.: 22 назв. — англ. | uk_UA |
| dc.identifier.issn | 1812-9269 | |
| dc.identifier.uri | http://dspace.nbuv.gov.ua/handle/123456789/139856 | |
| dc.description.abstract | Aim: Methotrexate (MTX) is an antifolate agent that acts inhibiting purine and pyrimidine synthesis. The objective of the study was to evaluate the viability of Hep-2 human laryngeal cancer cells to the treatment with MTX chemotherapy in vitro. Methods: Cultured Hep-2 cells were treated with 0.25, 25.0 and 75 μM MTX for 24 h, and their viability was evaluated with Bcl-2-FITC antibody in flow cytometry. Results: The numbers of viable Hep-2 cells after 24 h treatment with 0.25, 25.0 and 75.0 uM MTX were 85.43%, 22.46% and 8.42%, respectively (p < 0.05). Therefore, MTX possesses a dose-dependent effect on viability of Hep-2 cells in vitro. Conclusion: The highest MTX concentration is associated with highest tumor cell sensitivity of human laryngeal cancer cells of Hep-2 line. | uk_UA |
| dc.description.sponsorship | Fundação de Amparo а Pesquisa do Estado de Sгo Paulo (FAPESP) for their financial support (Nє 2010/12930-4, 2010/12932-7); Prof. Dr. Moacir F. Godoy for their help in statistical analysis; Profa. Dra Eloiza Helena Tajara for providing of the cell line; Oncology Department, Hospital de Base, São José do Rio Preto for providing of the Methotrexate Chemotherapeutic; CNPQ (National Counsel of Technological and Scientific Development) and FAMERP/FUNFARME. | uk_UA |
| dc.language.iso | en | uk_UA |
| dc.publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України | uk_UA |
| dc.relation.ispartof | Experimental Oncology | |
| dc.subject | Short communications | uk_UA |
| dc.title | Sensitivity of human laryngeal squamous cell carcinoma Hep-2 to metrotexate chemoterapy | uk_UA |
| dc.type | Article | uk_UA |
| dc.status | published earlier | uk_UA |
