Наукова електронна бібліотека
періодичних видань НАН України
періодичних видань НАН України
Mobile genetic elements and cancer. From mutations to gene therapy
Репозиторій DSpace/Manakin
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Mobile genetic elements and cancer. From mutations to gene therapy
Тема:
Reviews
Посилання:
Mobile genetic elements and cancer. From mutations to gene therapy / I.A. Kozeretska, S.V. Demydov, L.I. Ostapchenko // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 198-205. — Бібліогр.: 114 назв. — англ.
Підтримка:
Authors thank Andrii Rozhok for help in obtaining some papers and English translation.
Дата:
2011
Переглядів:
641
Завантажень:
269
Анотація:
In the present review, an association between cancer and the activity of the non-LTR retroelements L1, Alu, and SVA, as well as endogenous retroviruses, in the human genome, is analyzed. Data suggesting that transposons have been involved in embryogenesis and malignization processes, are presented. Events that lead to the activation of mobile elements in mammalian somatic cells, as well as the use of mobile elements in genetic screening and cancer gene therapy, are reviewed.
