Наукова електронна бібліотека
періодичних видань НАН України
періодичних видань НАН України
Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma
Репозиторій DSpace/Manakin
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Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma
Тема:
Original contributions
Посилання:
Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma / G.P. Potebnya, I.M. Voeykova, G.S. Lisovenko, N.L. Cheremshenko, I.M. Todor, O.Yu. Yudina, O.V. Kovtonyuk, V.F. Chekhun // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 226-230. — Бібліогр.: 36 назв. — англ.
Підтримка:
The study was performed within the frames of the project “Peculiarities of oncogenome functioning” (№ 0102U003228) with the financial support of target scientific program of NAS of Ukraine “Physiologicalbiochemical and molecular-genetic basis of live systems functioning and development of principles of their control”.
Дата:
2009
Переглядів:
631
Завантажень:
161
Анотація:
To study antitumor and antimetastatic activities of antitumor vaccine (ATV) prepared from cisplatin (CP) sensitive and resistant strains of Lewis lung carcinoma (LLC). Methods: The inhibition of tumor growth, and the mean survival time of the tumor-bearing animals, the number and the volume of metastases were measured as the indices of ATV efficacy. The activity of cytotoxic T-lymphocytes and natural killer cells, peritoneal macrophages (Mph), the level of tumor necrosis factor and the total proteolytic activity of blood plasma (PA) were assessed. Results: ATV from CP resistant LLC prepared using cytolectin (CL) of В. subtilis В-7025 significantly inhibited growth of CP resistant tumors (by 52%) and increased mean survival time (MST) of animals (by 44.6%). The index of metastasis inhibition for ATV prepared from CP sensitive or resistant LLC was 154.5% and 227.0%, respectively. In all vaccine-treated animals, Mph activity was shown to be significantly increased. In spite of high antitumor and antimetastatic effects of ATV prepared from CP resistant LLC, PA in plasma of animals inoculated with CP resistant LLC was increased significantly upon vaccine administration.
