Перегляд за темою "Bioorganic Chemistry"

Результати 21-37 з 37

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MI1 – derivative of maleimide inhibits cell cycle progression in tumor cells of epithelial origin

Garmanchuk, L.V.; Denis, E.O.; Nikulina, V.V.; Dzhus, O.I.; Skachkova, O.V.; Ribalchenko, V.K.; Ostapchenko, L.I. (Вiopolymers and Cell, 2013)

Aim. MI1 is a promising maleimide derivative, which exhibits antiproliferative effect on different cells. The aim of present study was to investigate influence of MI1 on the cell cycle of cancer cells and its cytotoxity. ...
Molecular complexes of the triterpene glycosides with L-tyrosine and their biological activity

Yakovishin, L.A.; Lekar, A.V.; Vetrova, E.V.; Borisenko, N.I.; Borisenko, S.N.; Grishkovets, V.I. (Вiopolymers and Cell, 2012)

Aim. To investigate the complexation of L-tyrosine (Tyr) with hederagenin 3-O-α-L-rhamnopyranosyl-(1→2)-O-α-Larabinopyranoside (α-hederin) and its 28-O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranosyl ...
N-alkylaryl styrylcyanine dyes as fluorescent probes for nucleic acids detection

Kuperman, M.V.; Snihirova, Y.V.; Kryvorotenko, D.V.; Losytskyy, M.Yu.; Kovalska, V.B.; Yarmoluk, S.M. (Вiopolymers and Cell, 2018)

Aim. To synthesize and characterize a series of N-alkylaryl benzothiazole styrylcyanine dyes as potential ﬂuorescent probes for nucleic acids (NA) detection. Methods. Synthesis, absorption and fluorescence spectroscopy, ...
Ò7 Evaluation of antibacterial and antiviral activity of N-arylamides of 9-methyl- and 9-methoxyphenazine-1-carboxylic acids – inhibitors of the phage T7 model transctiption

Palchykovska, L.G.; Vasylchenko, O.V.; Platonov, M.O.; Kostina, V.G.; Babkina, M.M.; Tarasov, O.A.; Starosyla, D.B.; Samijlenko, S.P.; Rybalko, S.L.; Deriabin, O.M.; Hovorun, D.M. (Вiopolymers and Cell, 2012)

Aim. Search for compounds with antibacterial and antiviral properties among N-arylamides of 9-substituted phenazine-1-carboxylic acids (PCA), inhibitors of the RNA synthesis. Methods. Influence of N-aryl-amides on the RNA ...
Screening of antioxidant and anti-inflammatory activities among thiopyrano[2,3-d]thiazoles

Lozynskyi, A.V.; Kaminskyy, D.V.; Romanchyshyn, Kh.B.; Semenciv, N.G.; Ogurtsov, V.V.; Nektegayev, I.O.; Lesyk, R.B. (Вiopolymers and Cell, 2015)

The aim of present research was the investigation of antioxidant and antiexudative activities of the series of thiopyrano[2,3-d]thiazoles synthesized based on cinnamic acid amides. Methods. Organic synthesis; spectral ...
Screening of spiro-substituted thiopyrano[2,3-d]thiazoles for their cytotoxic action on tumor cells

Zelisko, N.I.; Finiuk, N.S.; Shvets, V.M.; Medvid, Yu.O.; Stoika, R.S.; Lesyk, R.B. (Вiopolymers and Cell, 2017)

Aim. To evaluate the in vitro cytotoxicity of novel spiro-substituted thiopyrano[2,3-d]thiazoles towards tumor cells of different tissue origin. Methods. Organic synthesis; spectral methods; MTT test, statistical analysis. ...
Spectroscopic study of binding of a cationic Pheophorbide-a to an antiparallel quadruplex Tel22

Ryazanova, O.A.; Zozulya, V.N.; Voloshin, I.M.; Glamazda, A.Yu.; Dubey, I.Ya.; Dubey, L.V.; Karachevtsev, V.A. (Вiopolymers and Cell, 2019)

Aim. To study the binding of a water-soluble cationic Pheophorbide-a derivative (CatPheo-a) ta a Na+–stabilized antiparallel quadruplex formed by 22-mer oligonucleotide d[AG3(T2AG3)3] of the human DNA telomeric sequence ...
Structure–anticancer activity relationships among 4-azolidinone-3-carboxylic acids derivatives

Kaminskyy, D.V.; Lesyk, R.B. (Вiopolymers and Cell, 2010)

The aim of present research was investigation of anticancer activity of 4-azolidinone-3-carboxylic acids derivatives, and studies of structure–activity relationships (SAR) aspects. Methods. Organic synthesis; spectral ...
Synthesis and antitumor activities of new N-(5-benzylthiazol-2-yl)-2-(heteryl-5-ylsulfanyl)-acetamides

Ostapiuk, Yu.V.; Frolov, D.A.; Vasylyschyn, R.Ya.; Matiychuk, V.S. (Вiopolymers and Cell, 2018)

Aim. Synthesis of series of new N-(5-benzyl-thiazol-2-yl)-2-(heteryl-5-ylsulfanyl)-acetamides and study on their anticancer activity. Methods. Organic synthesis, analytical and spectral meth-ods, pharmacological screening. ...
Synthesis and biological evaluation of novel amino-substituted derivatives of pyrido[2,3-d]pyrimidine as inhibitors of protein kinase CK2

Zinchenko, A.N.; Muzychka, L.V.; Smolii, O.B.; Bdzhola, V.G.; Protopopov, M.V.; Yarmoluk, S.M. (Вiopolymers and Cell, 2017)

Aim. A search for human protein kinase CK2 inhibitors in a series of new amino-substituted pyrido[2,3-d]pyrimidine derivatives. Methods. Organic synthesis, analytical and spectral methods, molecular docking, in vitro ...
Synthesis and evaluation of antitumor activity of some thiazolo[4,5-b]pyridines

Chaban, T.I.; Panchuk, R.R.; Klenina, O.V.; Skorokhyd, N.R.; Ogurtsov, V.V.; Chaban, I.G. (Вiopolymers and Cell, 2012)

Aim. To synthesize a series of novel 3H-thiazolo[4,5-b]pyridine-2-ones by structural modification of the core heterocycle in its N3- and N6-positions and to evaluate their anticancer activity in vitro on several tumor cell ...
Synthesis and optical properties of lanthanides doped ultrasmall NaYF₄ markers for bio-medical applications

Podhorodecki, A.; Banski, M.; Misiewicz, J. (Вiopolymers and Cell, 2011)

Aim. To synthesise NaYF₄ nanocrytstals doped or co-doped with different lanthanide ions (Eu, Tb, Gd) and to investigate them optically to achieve efficient optical markers. Methods. Samples have been synthesized by ...
Toxic effect of C₆₀ fullerene-doxorubicin complex towards tumor and normal cells in vitro

Prylutska, S.V.; Didenko, G.V.; Potebnya, G.P.; Bogutska, K.I.; Prylutskyy, Yu.I.; Ritter, U.; Scharff, P. (Вiopolymers and Cell, 2014)

Creation of new nanostructures possessing high antitumor activity is an important problem of modern biotechnology. Aim. To evaluate cytotoxicity of created complex of pristine C₆₀ fullerene with the anthracycline antibiotic ...
Use of lectin as a vector molecule for delivery of medicinal products to cells and tissues

Antonyuk, V.O.; Klyuchivska, O.Yu.; Antonyuk, R.V.; Lozynskyi, A.V.; Pohranychna, Kh.R.; Lesyk, R.B.; Stoika, R.S. (Вiopolymers and Cell, 2016)

Aim. The conjugation of low-molecular compounds with antitumor activity to lectin and evaluation of the biological activity of the obtained conjugate. Methods. Organic synthesis; obtaining and analyzing Pisum sativum ...
Use of lectins as vector molecules for delivery of drugs to cells and tissues. Report 2.

Antonyuk, V.O.; Skorohyd, N.R.; Lozynskyi, A.V.; Antonyuk, R.V.; Lesyk, R.B.; Stoika, R.S. (Вiopolymers and Cell, 2019)

Aim.To determine cytotoxic effects towards a tumor cells culture of the heterocyclic derivative conjugated with lectins of different carbohydrate specificity. Methods. Conjugation of lectins (Pea seeds (PSA), peanuts (PNA) ...
Молекулярные комплексы тритерпеновых гликозидов с L-гистидином и их биологическая активность

Яковишин, Л.А.; Лекарь, А.В.; Ветрова, Е.В.; Борисенко, Н.И.; Гришковец, В.И. (Вiopolymers and Cell, 2011)

Цель. Исследовать комплексообразование L-гистидина (His) с 3-О-a-L-рамнопиранозил-(1→2)-О-a-Lарабинопиранозидом хедерагенина (a-хедерином) и его 28-О-a-L-рамнопиранозил-(1→4)-О-b-D-глюкопиранозил-(1→6)-О-b-D-глюкопиранозиловым ...
Спектрально-люминесцентные свойства производных скварилиевых зондов при взаимодействии с изолированными клетками печени крыс

Ткачева, Т.Н.; Кавок, Н.С.; Боровой, И.А.; Обухова, Е.Н.; Климов, С.А.; Малюкин, Ю.В. (Вiopolymers and Cell, 2012)

Цель. Поиск подходов к исследованию функционального состояния клетки с помощью новых скварилиевых зондов. Методы. Зависимость параметров флуоресценции скварилиевых и полиметиновых красителей от свойств их микроокружения в ...

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