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Перегляд Biopolymers and Cell за автором "Malanchuk, O.M."

Репозиторій DSpace/Manakin

Перегляд Biopolymers and Cell за автором "Malanchuk, O.M."

Сортувати за: Порядок: Результатів:

  • Association of Rictor with chromosomes during mitosis in MCF7 cells 
    Malanchuk, O.M. (Вiopolymers and Cell, 2015)
    The mTOR kinase forms two multicomponent protein complexes (mTORC1 and mTORC2), where protein Rictor is a unique component of mTORC2. These two complexes differ both structurally and functionally and transmit signals to ...
  • Dephosphorylation of tuberous sclerosis complex 2 by serine/threonine protein phosphatase 5 
    Malanchuk, O.M.; Palchevskyy, S.S.; Filonenko, V.V. (Біополімери і клітина, 2008)
    We report here for the first time specific interaction between tuberous sclerosis complex 2 (TSC2) and protein phosphatase 5 (PP5) in mammalian cells. We found that the interaction is stronger in exponentially growing and ...
  • Development of monoclonal antibody against protein Rictor, a component of the mTORC2 complex 
    Malanchuk, O.M. (Вiopolymers and Cell, 2015)
    Aim. Rictor is a component of the protein complex mTORC2 that is activated by growth factors and regulates cell growth, survival and migration. Here, we describe the development of the Rictor specific monoclonal antibody ...
  • Generation and characterization of monoclonal antibodies specific to Coenzyme A 
    Malanchuk, O.M.; Panasyuk, G.G.; Serbyn, N.M.; Gout, I.T.; Filonenko, V.V. (Вiopolymers and Cell, 2015)
    Aim. Generation of monoclonal antibodies specific to Coenzyme A. Methods. Hybridoma technique. KLH carrier protein conjugated with CoA was used for immunization. Screening of positive clones was performed with BSA conjugated ...
  • Generation and characterization of monoclonal antibodies specific to Coenzyme A 
    Malanchuk, O.M.; Panasyuk, G.G.; Serbyn, N.M.; Gout, I.T.; Filonenko, V.V. (Вiopolymers and Cell, 2015)
    im. Generation of monoclonal antibodies specific to Coenzyme A. Methods. Hybridoma technique. KLH carrier protein conjugated with CoA was used for immunization. Screening of positive clones was performed with BSA conjugated ...
  • Generation of monoclonal antibodies specific to ribosomal protein S6 kinase 1 
    Savinska, L.O.; Klipa, O.M.; Demchuk, N.O.; Ovcharenko, G.V.; Malanchuk, O.M.; Tykhonkova, I.O.; Palchevskyy, S.S.; Filonenko, V.V. (Вiopolymers and Cell, 2012)
    The aim of this study was to produce monoclonal antibodies directed to the N-terminal regulatory region of S6K1, which shows very low homology to S6K2. Methods. Hybridoma technology, ELISA, Western blot, Immunoprecipitation. ...
  • Generation of monoclonal antibody against protein phosphatase 5 
    Malanchuk, O.M.; Ovcharenko, G.V.; Tykhonkova, I.O.; Khoma, O.S.; Chorna, U.V.; Rybak, M.Yu.; Palchevskyy, S.S. (Вiopolymers and Cell, 2013)
    Aim. Serine/threonine protein phosphatase 5 (PP5) is a unique member of serine/threonine phosphatase family, comprises a regulatory tetratricopeptide repeat (TPR) domain and regulates many cell signaling pathways. Here, ...
  • Interaction of serine/threonine protein phosphatase 5 with the protein products of tumour suppressor gene Tsc2 
    Malanchuk, O.M.; Palchevskyy, S.S.; Pozur, V.K.; Gout, I.T.; Filonenko, V.V. (Біополімери і клітина, 2007)
    Tuberous sclerosis (TSC) is a tumour disease caused by mutations in Tsc1 or Tsc2 genes. Both protein products of Tsc1 and Tsc2 form an intracellular complex possessing GTPase-activating (GAP) activity towards a small GTP ...

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