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Перегляд Відділення біохімії, фізіології та молекулярної біології за темою "Short Communications"

Репозиторій DSpace/Manakin

Перегляд Відділення біохімії, фізіології та молекулярної біології за темою "Short Communications"

Сортувати за: Порядок: Результатів:

  • Ca²⁺ does not affect the binding properties of ITSN1 EH domains 
    Morderer, D.Ye.; Rymarenko, O.V.; Skrypkina, I.Ya.; Rynditch, A.V. (Вiopolymers and Cell, 2014)
    ITSN1 is an endocytic scaffold protein implicated in synaptic functioning. Ca²⁺ is known to be important for endo- cytosis in both pre- and post-synaptic terminals. ITSN1 contains two EH (Eps15 homology) domains which ...
  • Ca/calmodulin-dependent phosphorylation of endocytic scaffold ITSN1 
    Morderer, D.Ye.; Nikolaienko, O.V.; Skrypkina, I.Ya.; Rymarenko, O.V.; Kropyvko, S.V.; Tsyba, L.O.; Rynditch, A.V. (Вiopolymers and Cell, 2014)
    ITSN1 is an endocytic scaffold protein with a prominent function in synaptic transmission. It is known that Ca signaling is crucial for the regulation of synaptic proteins functioning. Aim. Checking the possibility of ...
  • Comparative analysis of human and mammalias genes of protein ortologs of cytochrome P450 2E1 
    Duplij, D.R.; Maksymchuk, O.V.; Duplij, V.P.; Chaschin, N.A. (Вiopolymers and Cell, 2010)
    Aim. To carry out a comparison analysis of nucleotide sequences for the cytochrome P450 2E1 protein ortologs genes and reestablish the connection of gene evolution with nucleotide content. Methods. In silico: BLAST, ClustalW, ...
  • Coxsackievirus infections in pregnant women with a parallel experimental model infection showing possible effects on course of pregnancy 
    Marosova, L.; Sojka, M.; Precechtelova, J.; Stipalova, D.; Badurova, M.; Borsanyiova, M.; Bopegamage, S. (Вiopolymers and Cell, 2011)
    Aim of our work was firstly to determine the prevalence of anti-coxsackievirus antibodies during pregnancy. 217 serum samples were tested for antibodies by virus neutralization test against coxsackieviruses (CV) B1–B6, ...
  • Differential recognition of ITSN2/Ese2 by the SH2 domains of Fyn, Abl1, PLCg1 and PI3KR1 in mouse tissues 
    Novokhatska, O.V.; Pankivskyy, S.V.; Dergai, M.V.; Tsyba, L.O.; Rynditch, A.V. (Вiopolymers and Cell, 2013)
    Phosphorylation of endocytic adaptor ITSN2 that enabled its interaction with the SH2 domains of signaling proteins was recently reported. The aim of this study was to determine whether tissue-specific ITSN2 phosphorylation ...
  • DNA import competence and mitochondrial genetics 
    Weber-Lotfi, F.; Mileshina, D.V.; Ibrahim, N.; Koulintchenko, M.V.; D'Souza, G.; Saxena, V.; Konstantinov, Yu.M.; Lightowlers, R.N.; Dietrich, A. (Вiopolymers and Cell, 2014)
    Aim. To understand the mechanism(s) underlying mitochondrial competence for DNA uptake and to exploit these pathways for the development of in vivo models of gene therapy. Methods. DNA uptake into isolated mitochondria ...
  • Dopamine receptor type 1 of Caenorhabditis elegans expressing in mechanosensory neurons 
    Stadnyk, V.V.; Regosh A.; Mayor, C.Y.; Fomenko, I.S.; Bondarchuk, T.I.; Sklyarov, O.Y. (Вiopolymers and Cell, 2012)
    Until now the results on profiling dopamine receptors in C. elegans have been incomplete and fragmentary. The aim of this study was to investigate the expression profile of dop-1 gene in C. elegans using 3 kb promoter with ...
  • Effect of multifunctional protein YB-1 on the AP site cleavage by AP endonuclease 1 and tyrosyl phosphodiesterase 1 
    Pestryakov, P.E.; Khodyreva, S.N.; Curmi, P.A.; Ovchinnikov, L.P.; Lavrik, O.I. (Вiopolymers and Cell, 2012)
    Апуринові/апіримідинові сайти (АП-сайти), які є одними з найчисельніших пошкоджень ДНК у клітині, репаруються, в основному, шляхом ексцизійної репарації основ (ЕРО). Багатофункціональний білок YB-1 бере участь у клітинній ...
  • Glioma-associated protein CHI3L2 suppresses cells viability and induces G1/S transition arrest 
    Avdieiev, S.S.; Gera, L.; Hodges, R.; Dmytrenko, V.V. (Вiopolymers and Cell, 2015)
    Aim. To analyze the effect of the CHI3L2 protein on malignant and non-malignant cell viability, and determined the CHI3L2 impact on the cell cycle and signaling pathways involved in the cell cycle regulation. Methods. ...
  • Growth suppression activity of bradykinin antagonists in glioma cells 
    Avdieiev, S.S.; Gera, L.; Hodges, R.; Vassetzky, Y.S.; Kavsan, V.M. (Вiopolymers and Cell, 2014)
    The present study was Aimed at analyzing the effect of bradykinin (BK) antagonists on proliferation of the human glioblastoma cells U373. Methods. MTT-based cell proliferation assay. Results. BKM-570 revealed a significant ...
  • Human and bacterial DNA polymerases discriminate against 8-oxo-2'-deoxyadenosine- 5'-triphosphate 
    Grin, I.R.; Vasilyeva, S.V.; Dovgerd, A.P.; Silnikov, V.N.; Zharkov, D.O. (Вiopolymers and Cell, 2012)
    Цель. 8-оксоаденин – распространенное поврежденное основание, ассоциированное с онкологическими и нейродегенеративными заболеваниями. Оно может возникать вследствие непосредственного окисления аденина в ДНК или при включении ...
  • Human cultured cells are capable to incorporate isolated plant mitochondria loaded with exogenous DNA 
    Klimenko, E.S.; Zaporozhchenko, I.A.; Mileyko, V.A.; Morozkin, E.S.; Koulintchenko, M.V.; Laktionov, P.P.; Konstantinov, Yu.M. (Вiopolymers and Cell, 2012)
    Aim. To investigate the possibility of human cultured cells to incorporate isolated mitochondria together with exogenous DNA introduced into organelles. Methods. Two approaches were used for this purpose, fluorescent ...
  • IFN-l-3 (IL28B) genotyping by restriction fragment length polymorphism method: detection polymorphism of rs12979860 
    Pampukha, V.M.; Kravchenko, S.A.; Moroz, L.V.; Livshits, L.A. (Вiopolymers and Cell, 2011)
    Aim. The goal of our study was to develop an accurate detection of the SNP rs12979860 by RFLP-based method and to evaluate the polymorphic genotype distribution forthis SNP among individuals with unknown HCV status from ...
  • Increasing of antioxidant and superoxide dismutase activity in chicory transgenic plants 
    Kvasko, O.Yu.; Matvieieva, N.A. (Вiopolymers and Cell, 2013)
    Aim. Determination of the antioxidant activity (AOA) and superoxide dismutase (SOD) activity in transgenic chicory plants carrying the human interferon α2b target and nptII or bar selective genes. Methods. AOA was measured ...
  • Multisubunit complex eEF1H in human glial tumors: from mRNA to protein 
    Veremieva, M.V.; Malysheva, T.A.; Zozulya, Y.P.; Rozumenko, V.D.; Sidorik, L.L.; Kavsan, V.M.; Negrutskii, B.S.; El'skaya, A.V. (Вiopolymers and Cell, 2010)
    Aim. To investigate protein level of all subunits of the eukaryotic elongation translation factor eEF1H (eEF1A, eEF1Bα, eEF1Bβ and eEF1Bγ) in glial tumors of human brain in comparison with normal brain. Methods. The eEF1H ...
  • New partners of TKS4 scaffold protein 
    Kropyvko, S.V. (Вiopolymers and Cell, 2015)
    TKS4 scaffold protein is involved in the formation of invadopodia, the production of reactive oxygen species (ROS) by tumor cells and other cellular processes. Aim. To identify new TKS4 partners involved in the actin ...
  • Novel antibodies against RCD-8 as a tool to study processing bodies 
    Gudkova, D.O.; Panasyuk, G.G.; Nemazanyy, I.O.; Filonenko, V.V. (Вiopolymers and Cell, 2010)
    Aim. To develop the model system for processing bodies (PBs) state monitoring and accomplish it in the future as a possible read-out of mTOR activity in mammalian cells. Methods. In course of this study we raised polyclonal ...
  • Novel isoform of adaptor protein ITSN1 forms homodimers via its C-terminus 
    Dergai, M.V.; Dergai, O.V.; Tsyba, L.O.; Novokhatska, O.V.; Skrypkina, I.Ya.; Rynditch, A.V. (Вiopolymers and Cell, 2011)
    Aim. Previously we have identified a novel isoform of endocytic adaptor protein ITSN1 designated as ITSN1- 22a. Western blot revealed two immunoreactive bands of 120 and 250 kDa that corresponded to ITSN1-22a. The goal ...
  • Persistence of viral RNA in the brain of experimentally infected mice with coxsackievirus B5 
    Stipalova, D.; Sojka, M.; Borsanyiova, M.; Badurova, M.; Marosova, L.; Sobotova, Z.; Bopegamage, S. (Вiopolymers and Cell, 2011)
    Aim. The aim of our study was to follow the persistence of viral RNA in selected organs of experimentally infected with coxsackievirus (CV) B5 strains from different sources such as a patient’s sample, an environmental ...
  • Polysulfide compounds as inhibitors of the key base excision repair enzymes 
    Kutuzov, M.M.; Zakharenko, A.L.; Sukhanova, M.V.; Khodyreva, S.N.; Khomenko, T.M.; Volcho, K.P.; Salakhutdinov, N.F.; Lavrik, O.I. (Вiopolymers and Cell, 2012)
    Цель. Чтобы повысить эффективность противоопухолевой терапии, основанной на повреждениях ДНК, важно минимизировать исправление этих повреждений, что может быть достигнуто за счет подавления активности ключевых ферментов ...

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