Генетические факторы нарушения сперматогенеза у мужчин со сниженной репродуктивной функцией

dc.contributor.author	Жилкова, Е.С.
dc.contributor.author	Феськов, А.М.
dc.contributor.author	Безпечная, И.М.
dc.contributor.author	Федота, А.М.
dc.date.accessioned	2021-02-17T21:18:48Z
dc.date.available	2021-02-17T21:18:48Z
dc.date.issued	2014
dc.identifier.citation	Генетические факторы нарушения сперматогенеза у мужчин со сниженной репродуктивной функцией / Е.С. Жилкова, А.М. Феськов, И.М. Безпечная, А.М. Федота // Фактори експериментальної еволюції організмів: Зб. наук. пр. — 2014. — Т. 14. — С. 201-204. — Бібліогр.: 27 назв. — рос.	uk_UA
dc.identifier.issn	2219-3782
dc.identifier.uri	http://dspace.nbuv.gov.ua/handle/123456789/178114
dc.description.abstract	Aims. The correlation of DNA fragmentation level with classic sperm parameters, the male age and the level of immature spermatozoa and sperm aneuploidies was investigated. Methods. The level of the sperm DNA fragmentation was measured by the method of sperm chromatin dispersion. Semen aneuploidies were detected by the method of fluorescence in situ hybridization. The level of immature spermatozoa was measured by hyaluron binding assay. Results. There is a negative correlation between the DNA fragmentation level and sperm motility and sperm morphology. The significant negative correlation between DNA fragmentation level and immature spermatozoa level is proved. There is a negative correlation between the levels of DNA fragmentation and sperm aneuploidies. Conclusions. The failures of sperm DNA compactization influence on classic sperm parameters and correlates with the level of aneuploidies. There is a dependence of DNA fragmentation level on the male age. The critical clinically significant age for DNA fragmentation is 30 years old. Key words: DNA fragmentation, aneuploidy, mature sperm, FISH.	uk_UA
dc.language.iso	ru	uk_UA
dc.publisher	Інститут молекулярної біології і генетики НАН України	uk_UA
dc.relation.ispartof	Фактори експериментальної еволюції організмів
dc.subject	Генетика людини та медична генетика	uk_UA
dc.title	Генетические факторы нарушения сперматогенеза у мужчин со сниженной репродуктивной функцией	uk_UA
dc.title.alternative	Genetic factors of spermatogenesis failures in men with low reproductive function	uk_UA
dc.type	Article	uk_UA
dc.status	published earlier	uk_UA
dc.identifier.udc	573.6:577.21–075