Анализ ассоциаций полиморфных вариантов гена MTHFR с онкопатологиями у пробандов с псориазом и их родственников

dc.contributor.author	Федота, А.М.
dc.contributor.author	Беляева, Л.В.
dc.contributor.author	Солодянкин, А.С.
dc.contributor.author	Адмакина, А.В.
dc.date.accessioned	2021-02-17T15:57:22Z
dc.date.available	2021-02-17T15:57:22Z
dc.date.issued	2013
dc.identifier.citation	Анализ ассоциаций полиморфных вариантов гена MTHFR с онкопатологиями у пробандов с псориазом и их родственников / А.М. Федота, Л.В. Беляева, А.С. Солодянкин, А.В. Адмакина // Фактори експериментальної еволюції організмів: Зб. наук. пр. — 2013. — Т. 13. — С. 345-349. — Бібліогр.: 20 назв. — рос.	uk_UA
dc.identifier.issn	2219-3782
dc.identifier.uri	http://dspace.nbuv.gov.ua/handle/123456789/178027
dc.description.abstract	Aim. Research association of polymorphic variants of genes of folate metabolism with cancer in a ukrainian population had been investigated. Methods. Genealogical analysis of 68 probands and 440 relatives was carried out. Genomic DNA of 68 patients was analyzed by polymerase chain reaction. Results. Statistically significant higher cancer pathology burdened with native I–degree relatives of probands compared to genotypes CC–AA and TT–AA compared with population frequency. Probands with genotype CT–AC were the least burdened by native I–degree relatives with cancer pathology. Conclusion. The study of the frequency of malignant neoplasms in patients with psoriasis showed that among them persons with oncological diseases are not detected. It is known that cysteine is a powerful antioxidant, that, apparently, is one of the factors cancer protector not only for patients with psoriasis, but also for their native I–degree relatives as heterozygotes for single nucleotide polymorphisms C677T and A1298C MTHFR gene. Key words: psoriasis, cancer, hyperhomocysteinemia, methylenetetrahydrofolate reductase.	uk_UA
dc.language.iso	ru	uk_UA
dc.publisher	Інститут молекулярної біології і генетики НАН України	uk_UA
dc.relation.ispartof	Фактори експериментальної еволюції організмів
dc.subject	Генетика людини та медична генетика	uk_UA
dc.title	Анализ ассоциаций полиморфных вариантов гена MTHFR с онкопатологиями у пробандов с псориазом и их родственников	uk_UA
dc.title.alternative	Analysis of associations of polimorphic variants of MTHFR gene in cancer probands with psoriasis and their relatives	uk_UA
dc.type	Article	uk_UA
dc.status	published earlier	uk_UA