Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo

Домашня сторінка
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Хімічні та біологічні науки
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Відділення біохімії, фізіології та молекулярної біології
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Experimental Oncology
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Experimental Oncology, 2014 (том 36)
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Experimental Oncology, 2014, № 1
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dc.contributor.author	Gevorkyan, L.
dc.contributor.author	Gambashidze, K.
dc.date.accessioned	2019-01-20T11:14:01Z
dc.date.available	2019-01-20T11:14:01Z
dc.date.issued	2014
dc.identifier.citation	Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo / L. Gevorkyan, K. Gambashidze // Experimental Oncology. — 2014. — Т. 36, № 1. — С. 48-49. — Бібліогр.: 3 назв. — англ.	uk_UA
dc.identifier.issn	1812-9269
dc.identifier.uri	http://dspace.nbuv.gov.ua/handle/123456789/145329
dc.description.abstract	Aim: The aim of the presented article was investigation of anticancer efficacy of hydroxyethylthiamine diphosphate (HTD) in vivo. Materials and Methods: The study was carried out on 30 C57BL/6J mice subcutaneously transplanted with Ehrlich carcinoma. Animals were treated with intraperitoneal injections of the solution composed from pyruvic acid and thiamine bromide every other day during 10 days and thereafter, every day during 2 weeks. Treatment efficacy was evaluated by tumor growth inhibition. Results: In experimental animals treated with HTD, significant tumor growth inhibition has been registered: 73% at day 45th compared to the control group (p < 0.001). Conclusion: Treatment with HTD demonstrated high anticancer efficacy in vivo. Key Words: carcinogenesis, pH, hydroxyethylthiamine diphosphate, lipoic acid amide.	uk_UA
dc.language.iso	en	uk_UA
dc.publisher	Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України	uk_UA
dc.relation.ispartof	Experimental Oncology
dc.subject	Short communications	uk_UA
dc.title	Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo	uk_UA
dc.type	Article	uk_UA
dc.status	published earlier	uk_UA