Наукова електронна бібліотека
періодичних видань НАН України
періодичних видань НАН України
Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate
Репозиторій DSpace/Manakin
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Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate
Тема:
Short communications
Посилання:
Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate / R.B. Pai, R.M. Lalitha, S.B. Pai, S.V. Kumaraswamy, N. Lalitha, M.K. Bhargava // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 118–120. — Бібліогр.: 14 назв. — англ.
Підтримка:
This study was supported by the Indian Council
of Medical Research, New Delhi, India. We thank
Rohith Pai for critical reading of the manuscript and
valuable suggestions.
Дата:
2009
Переглядів:
756
Завантажень:
238
Анотація:
Aim: The present study was directed on the assessment of the response of treatment-naive oral cancer cells to methotrexate (MTX)
in vitro and clinical response to MTX therapy. Methods: A pilot study of in vitro evaluation of MTX response of oral cancer cells
from 10 patients was conducted using a cell viability assay to determine the sensitivity/resistance to MTX. Quantitative in vitro data
were correlated to the clinical outcome to MTX therapy. Results: A positive correlation was observed between the effect of MTX
on tumor cells in vitro and clinical response for 7 out of 10 patients. Conclusions: Observations from the proof-of-principle pilot
study suggests that oral cancer cells have intrinsically variable response toMTX. Confirmation ofthese findings with a larger cohort
of patients could aid in the development of individualized therapies for this class of malignancy.
