Наукова електронна бібліотека
періодичних видань НАН України

Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance

Репозиторій DSpace/Manakin

Показати простий запис статті

dc.contributor.author Xu, X.
dc.contributor.author Yuan, G.
dc.contributor.author Liu, W.
dc.contributor.author Zhang, Y.
dc.contributor.author Chen, W.
dc.date.accessioned 2018-06-15T13:59:40Z
dc.date.available 2018-06-15T13:59:40Z
dc.date.issued 2009
dc.identifier.citation Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance / X. Xu, G. Yuan, W. Liu, Y. Zhang, W. Chen // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 102-105. — Бібліогр.: 19 назв. — англ. uk_UA
dc.identifier.issn 1812-9269
dc.identifier.uri http://dspace.nbuv.gov.ua/handle/123456789/135696
dc.description.abstract Aim: To study the expression of cathepsin L in nasopharyngeal carcinoma (NPC), and analyze its relationship with clinicopathologic factors. Methods: The expression of cathepsin L was determined immunohistochemically in NPC, adjacent normal nasopharyngeal tissues and metastatic cervical lymph nodes. The correlation between its protein expression and clinicopathologic parameters as well as with long term follow-up data in NPC was analyzed. Results: The protein of cathepsin L was overexpressed in 47% primary tumor tissues, and in 89% metastatic cervical lymph node samples. Overexpression of cathepsin L was found to correlate with lymph node metastasis (P = 0.04) and distant metastasis (P = 0.01), and marginally with clinical stage and T classification, but not with patient age, gender and histological classification of tumor. Patients with overexpression of cathepsin L in tumor tissue had worse 5-year survival than those without such expression pattern (P= 0.033). Multivariate survival analysis showed that cathepsin L protein expression level had a marginal significant correlation with prognosis of NPC. Conclusion: Cathepsin L is a potential biomarker for prognosis of NPC and contributes to NPC metastasis. uk_UA
dc.language.iso en uk_UA
dc.publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України uk_UA
dc.relation.ispartof Experimental Oncology
dc.subject Original contributions uk_UA
dc.title Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance uk_UA
dc.type Article uk_UA
dc.status published earlier uk_UA


Файли у цій статті

Ця стаття з'являється у наступних колекціях

Показати простий запис статті

Пошук


Розширений пошук

Перегляд

Мій обліковий запис