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dc.contributor.author |
Xu, X. |
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dc.contributor.author |
Yuan, G. |
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dc.contributor.author |
Liu, W. |
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dc.contributor.author |
Zhang, Y. |
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dc.contributor.author |
Chen, W. |
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dc.date.accessioned |
2018-06-15T13:59:40Z |
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dc.date.available |
2018-06-15T13:59:40Z |
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dc.date.issued |
2009 |
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dc.identifier.citation |
Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance / X. Xu, G. Yuan, W. Liu, Y. Zhang, W. Chen // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 102-105. — Бібліогр.: 19 назв. — англ. |
uk_UA |
dc.identifier.issn |
1812-9269 |
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dc.identifier.uri |
http://dspace.nbuv.gov.ua/handle/123456789/135696 |
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dc.description.abstract |
Aim: To study the expression of cathepsin L in nasopharyngeal carcinoma (NPC), and analyze its relationship with clinicopathologic factors.
Methods: The expression of cathepsin L was determined immunohistochemically in NPC, adjacent normal nasopharyngeal tissues and metastatic
cervical lymph nodes. The correlation between its protein expression and clinicopathologic parameters as well as with long term follow-up data
in NPC was analyzed. Results: The protein of cathepsin L was overexpressed in 47% primary tumor tissues, and in 89% metastatic cervical
lymph node samples. Overexpression of cathepsin L was found to correlate with lymph node metastasis (P = 0.04) and distant metastasis
(P = 0.01), and marginally with clinical stage and T classification, but not with patient age, gender and histological classification of tumor.
Patients with overexpression of cathepsin L in tumor tissue had worse 5-year survival than those without such expression pattern (P= 0.033).
Multivariate survival analysis showed that cathepsin L protein expression level had a marginal significant correlation with prognosis of NPC.
Conclusion: Cathepsin L is a potential biomarker for prognosis of NPC and contributes to NPC metastasis. |
uk_UA |
dc.language.iso |
en |
uk_UA |
dc.publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
uk_UA |
dc.relation.ispartof |
Experimental Oncology |
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dc.subject |
Original contributions |
uk_UA |
dc.title |
Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance |
uk_UA |
dc.type |
Article |
uk_UA |
dc.status |
published earlier |
uk_UA |
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