Перегляд за автором "Iatsyshyna, A.P."

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Correlation of mutagenesis level with expression of reparative enzyme O6-methylguanine DNA methyltransferase during establishment of cell lines in vitro

Macewicz, L.L.; Kushniruk, V.O.; Iatsyshyna, A.P.; Kotsarenko, K.V.; Lylo, V.V.; Akopyan, G.R.; Huleuk, N.L.; Mykytenko, D.O.; Lukash, L.L. (Вiopolymers and Cell, 2013)

Long-term cultivation of cell lines inevitably leads to genetic and epigenetic changes. The aim of this work was a comparative analysis of karyotype and level of the expression of reparative enzyme O6-methylguanine-DNA- ...
Current approaches to improve the anticancer chemotherapy with alkylating agents: state of the problem in world and Ukraine

Iatsyshyna, A.P. (Вiopolymers and Cell, 2012)

Alkylating agents are frequently used in many established anticancer chemotherapies. They alkylate the genomic DNA at various sites. Alkylation of the guanine at the O6-position is cytotoxic, it has the strongest mutagenic ...
MGMT expression: insights into its regulation. 1. Epigenetic factors

Iatsyshyna, A.P. (Вiopolymers and Cell, 2013)

O⁶-methylguanine-DNA methyltransferase (MGMT) is the DNA repair enzyme responsible for removing of alkylation adducts from the O6-guanine in DNA. Despite MGMT prevents mutations and cell death, this enzyme can provide ...
MGMT expression: insights into its regulation. 2. Single nucleotide polymorphisms

Iatsyshyna, A.P.; Pidpala, O.V.; Lukash, L.L. (Вiopolymers and Cell, 2013)

High intra- and interindividual variations in the expression levels of the human O6-methylguanine-DNA methyltransferase (MGMT) gene have been observed. This DNA repair enzyme can be a cause of resistance of cancer cells ...

Результати 1-4 з 4

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Перегляд за автором "Iatsyshyna, A.P."

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