Перегляд за автором "Gerashchenko, G.V."

Результати 1-15 з 15

A role of expression level of reference and investigated genes in prostate tumors for qPCR analysis

Gerashchenko, G.V.; Stakhovsky, E.O.; Chashchina, L.I.; Gryzodub, O.P.; Kashuba, V.I. (Вiopolymers and Cell, 2018)

Aim. To determine the expression profiles of a set of cancer-associated genes in prostate tumors, using various normalization protocols (with 1, 2 and 4 reference genes) and to optimize a combination of reference genes to ...
Detection of prostate specific ETS fusion transcripts in cancer samples

Mevs, L.V.; Gerashchenko, G.V.; Rosenberg, E.E.; Pikul, M.V.; Marynychenko, M.V.; Gryzodub, O.P.; Vozianov, S.O.; Stakhovsky, E.A.; Kashuba, V.I. (Вiopolymers and Cell, 2017)

Aim. To detect ETS fusion transcripts in Ukrainian population and to analyze a possible relationship between the ETS fusion transcripts and clinical characteristics of prostate cancer. Methods. Quantitative PCR (q-PCR) was ...
Development of gene expression panels to determine prostate cancer

Gerashchenko, G.V.; Rynditch, A.V.; Kashuba, V.I. (Доповіді НАН України, 2019)

The aim of this investigation is to prove a modified algorithm for statistical approaches to develop gene expression panels for the detection of prostate tumors. According to Classification and Regression tree models and ...
Expression of cancer-associated genes in prostate tumors

Rosenberg, E.E.; Gerashchenko, G.V.; Hryshchenko, N.V.; Mevs, L.V.; Nekrasov, K.A.; Lytvynenko, R.A.; Vitruk, Y.V.; Gryzodub, O.P.; Stakhovsky, E.A.; Kashuba, V.I. (Experimental Oncology, 2017)

Background: Prostate cancer is one of the most common male cancers in Western countries and takes the third place in morbidity in Ukraine. It is a highly heterogeneous disease. Aim: To analyze relative expression levels ...
Expression of cancer-associated genes in prostate tumors at mRNA and protein levels

Gerashchenko, G.V.; Grygoruk, O.V.; Rosenberg, E.E.; Bondarenko, Yu.M.; Kashuba, E.V.; Kashuba, V.I. (Вiopolymers and Cell, 2019)

Aim. To analyze an expression pattern of the cancer-associated genes in prostate tumors at mRNA and protein levels and find putative association between the expression of these genes and the genes, controlling epithelial ...
Expression of epithelial-mesenchymal transition-related genes in prostate tumours

Gerashchenko, G.V.; Mankovska, O.S.; Dmitriev, A.A.; Mevs, L.V.; Rosenberg, E.E.; Pikul, M.V.; Marynychenko, M.V.; Gryzodub, O.P.; Stakhovsky, E.O.; Kashuba, V.I. (Вiopolymers and Cell, 2017)

Aim. To detect expression of EMT-related genes in prostate tumor samples and analyze a possible correlation between gene expression level and clinical characteristics of prostate cancer in different groups. Methods. ...
Expression of steroid and peptide hormone receptors, metabolic enzymes and EMT-related genes in prostate tumors in relation to the presence of the TMPRSS2/ERG fusion

Gerashchenko, G.V.; Mevs, L.V.; Chashchina, L.I.; Pikul, M.V.; Gryzodub, O.P.; Stakhovsky, E.O.; Kashuba, V.I. (Experimental Oncology, 2018)

Aim: To analyze an expression pattern of the steroid and peptide hormone receptors, metabolic enzymes and EMT-related genes in prostate tumors in relation to the presence of the TMPRSS2/ERG fusion; and to examine a putative ...
Expression patterns of genes that regulate lipid metabolism in prostate tumors

Gerashchenko, G.V.; Kononenko, O.A.; Bondarenko, Yu.M.; Stakhovsky, E.O.; Kashuba, V.I. (Вiopolymers and Cell, 2018)

Aim. To assess relative expression (RE) levels of genes involved in lipid metabolism in prostate tumors. To define clinically significant specific alterations on the basis of the expression pattern. Methods. RE levels were ...
Genetic and epigenetic alterations of human chromosome 3, investigated by NotI-microarrays in seven types of epithelial cancers

Gerashchenko, G.V.; Gordiyuk, V.V.; Kashuba, V.I. (Інститут молекулярної біології і генетики НАН УкраїниВiopolymers and Cell, 2018)

Aim. To identify common and specific genetic/epigenetic changes of human chromosome 3, using the data of NotI-microarrays in seven types of epithelial cancers. Methods. We used descriptive statistics for the comparative ...
Genetic and epigenetic changes of GPX1 and GPX3 in human clear-cell renal cell carcinoma

Rudenko, E.E.; Gerashchenko, G.V.; Lapska, Y.V.; Bogatyrova, O.O.; Vozianov, S.O.; Zgonnyk, Y.M.; Kashuba, V.I. (Вiopolymers and Cell, 2013)

Aim. To find putative diagnostic and prognostic markers of cancerogenesis. Methods. Analysis of microarray and SAGE data, quantitative PCR (Q-PCR), bisulfite sequencing, methylation-specific PCR. Results. Bioinformatic ...
Genetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas

Gerashchenko, G.V.; Bogatyrova, O.O.; Rudenko, E.E.; Kondratov, A.G.; Gordiyuk, V.V.; Zgonnyk, Y.M.; Vozianov, O.F.; Pavlova, T.V.; Zabarovsky, E.R.; Rynditch, A.V.; Kashuba, V.I. (Experimental Oncology, 2010)

Renal cell carcinoma (RCC) is the most common malignant tumor of kidney associated with the worst clinical outcome. No molecular markers for RCC diagnostics and prognosis that could be applied in clinics were described ...
Heterozygous deletions are main cause of expression alterations of PPM1M and PRICLE2 genes in human clear cell renal cell carcinomas

Rudenko, E.E.; Lapska, Y.V.; Gerashchenko, G.V.; Stakhovsky, E.O.; Vikarchuk, M.V.; Kashuba, V.I. (2015)

Aim. To discover the mechanisms of the PPM1M and PRICKLE2 genes expression alterations in clear cell renal cell carcinomas. Methods. Study of the copy number was performed, using the quantitative PCR (Q-PCR). Results. ...
Novel epigenetic markers of early epithelial tumor growth and prognosis

Gordiyuk, V.V.; Kondratov, A.G.; Gerashchenko, G.V.; Kashuba, V.I. (Вiopolymers and Cell, 2013)

The present work is aimed at clarifying genetic and epigenetic alterations that occur during carcinogenesis and designing perspective sets of newly identified biomarkers. The tumors of kidney, cervix, colon, ovary, and ...
PPM1M and PRICKLE2 are potential tumor suppressor genes in human clear-cell renal cell carcinoma

Rudenko, E.E.; Gerashchenko, G.V.; Lapska, Y.V.; Vozianov, S.O.; Zgonnyk, Y.M.; Kashuba, V.I. (Вiopolymers and Cell, 2014)

Aim. To investigate the expression levels of PPM1M and PRICKLE2 in clear-cell renal cell carcinomas (ccRCC) and propose a mechanism leading to the expression changes in tumor. Methods. Analysis of GEO data, quantitative ...
The gene expression pattern as a tool for assessment of components of microenvironment and response to anti-cancer therapy of prostate tumors

Gerashchenko, G.V.; Chashchina, L.I.; Rynditch, A.V.; Kashuba, V.I. (Доповіді НАН України, 2019)

We have analyzed the putative value of the pattern of relative expression (RE) of several genes that might be involved in a response to anti-cancer therapy, namely AR, PTEN, COX2, FASN, HMGCR, LDLR, and CTLA4, in samples ...

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Перегляд за автором "Gerashchenko, G.V."

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Перегляд за автором "Gerashchenko, G.V."

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