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Перегляд Відділення біохімії, фізіології та молекулярної біології за темою

Перегляд Відділення біохімії, фізіології та молекулярної біології за темою "Structure and Function of Biopolymers"

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Adaptor protein TDRD7 is co-localized with ribosomal protein S6 kinases S6K1 and S6K2 in cell lines of different tissue origin

Skorokhod, O.M.; Khoruzhenko, A.I.; Filonenko, V.V. (Вiopolymers and Cell, 2013)

Our previous studies have shown that S6K1 and S6K2 protein kinases form the complexes with newly identified adaptor protein TDRD7, which is involved in regulation of cytoskeleton dynamics, mRNA transport, protein translation, ...
Aggregation of erythrocytes: a novel activity of HBD-2

Semeniuk, D.O.; Starenka, I.O.; Pogribna, A.P.; Sokol, I.V.; Govsieiev, D.O. (Вiopolymers and Cell, 2019)

Aim. To investigate an ability of HBD-2 to induce aggregation of erythrocytes. Methods. Aggregation assay, turbidimetry, light microscopy. Results. We have identified aggregation of erythrocytes in presence of at least ...
Alternatively spliced short and long isoforms of adaptor protein intersectin 1 form complexes in mammalian cells

Gubar, O.S.; Kropyvko, S.V.; Tsyba, L.O.; Gasman, S.; Rynditch, A.V. (Вiopolymers and Cell, 2012)

Intersectin 1 (ITSN1) is an adaptor protein involved in membrane trafficking and cell signaling. Long and short isoforms of ITSN1 (ITSN1-L and ITSN1-S) are produced by alternative splicing. The aim of our study was ...
Apocynin attenuates motility and induces transition from sustained to transient EGF-dependent Akt activation in MCF-7 cells that overexpress adaptor protein Ruk/CIN85

Bazalii, A.V.; Drobot, L.B.; Komisarenko, S.V. (Вiopolymers and Cell, 2016)

Aim. To study a possible involvement of NADPH oxidases in the control of cell motility and Akt signaling in the human breast adenocarcinoma MCF-7 cells that stably overexpress the full-length form of adaptor protein ...
Application of MALDI-TOF mass spectrometry for study on fibrillar and oligomeric aggregates of alpha-synuclein

Severinovskaya, O.V.; Kovalska, V.B.; Losytskyy, M.Yu.; Cherepanov, V.V.; Subramaniam, V.; Yarmoluk, S.M. (Вiopolymers and Cell, 2014)

Aim. To study the -synuclein (ASN) aggregates of different structural origin, namely amyloid fibrils and spherical oligomers, in comparison with a native protein. Methods. MALDI TOF mass spectrometry and atomic for- ce ...
Association of Rictor with chromosomes during mitosis in MCF7 cells

Malanchuk, O.M. (Вiopolymers and Cell, 2015)

The mTOR kinase forms two multicomponent protein complexes (mTORC1 and mTORC2), where protein Rictor is a unique component of mTORC2. These two complexes differ both structurally and functionally and transmit signals to ...
Bacterial expression and isotope labeling of AIMP1/p43 codosome protein for structural studies by multidimensional NMR spectroscopy

Vorobyova, N.V.; Lozhko, D.N.; Zhukov, I.Yu.; Kornelyuk, A.I. (Вiopolymers and Cell, 2015)

AIMP1/p43 protein is a structural component of multisynthetase complex (codosome) in eukaryotes, which reveals both tRNA binding and cytokine activities. Aim. Bacterial expression and purification of isotopically-labeled ...
Biofunctional nanomaterials based on ultra fine silica, protein and aminocarbohydrates

Galagan, N.P.; Klymenko, N.Y.; Orel, I.L.; Novikova, E.A.; Turov, V.V. (Вiopolymers and Cell, 2010)

Aim. Investigation of adsorptive interactions of N-acetyl-D-glucosamine (GlcNAc) and N-acetylneuraminic acid (NANA) with ultra fine silica (UFS) modified by protein bovine serum albumin (BSA). Methods. Adsorption, IR-, 1H ...
Characterization of new cell line stably expressing CHI3L1 oncogene

Balynska, O.V.; Baklaushev, V.P.; Areshkov, P.O.; Avdieiev, S.S.; Boyko, O.I.; Chekhonin, V.P.; Kavsan, V.M. (Вiopolymers and Cell, 2011)

Aim. To characterize the immortalized 293 cell line afterstable transfection with human oncogene (CHI3L1). Methods. 293 cells, stably transfected with pcDNA3.1_CHI3L1, and 293 cells, stably transfected with pcDNA3.1 as a ...
Chromatin enrichment of histone marks H4Ac and H3K9me3 in TP53 gene domain in breast cells

Santos, G.C.Jr; Goes, A.C.S.; de Moura Gallo, C.V. (Вiopolymers and Cell, 2014)

In non-cancerous breast cell lines HB2 and MCF10A the TP53 gene is localized inside a relatively small ~ 50 kb loop domain delimited by two S/MARs. Aim. To analyze the chromatin markers H4Ac and H3K9me3 of these two S/MARs ...
Chromatin in fractal globule state: evidence from comet assay

Afanasieva, K.S.; Chopei, M.I.; Sivolob, A.V. (Вiopolymers and Cell, 2015)

At higher order levels chromatin is organized into loops that appear as a result of contacts between distant loci. The aim of this work was to investigate the length distribution of the DNA loops in nucleoids obtained after ...
Cloning, expression and purification of D-Tyr-tRNATyr-deacylase from Thermus thermophilus

Rybak, M.Yu.; Kovalenko, O.P.; Kryklyvyi, I.A.; Tukalo, M.A. (Вiopolymers and Cell, 2015)

D-Tyr-tRNATyr-deacylase (DTD) is a conservative enzyme, found in all domains of life, which ensures an additional checkpoint in the recycling of misaminoacylated D-Tyr-tRNATyr. DTD is capable of accelerating the hydrolysis ...
Cloning, expression and purification of D-Tyr-tRNATyr-deacylase from Thermus thermophilus

Rybak, M.Yu.; Kovalenko, O.P.; Kryklyvyi, I.A.; Tukalo, M.A. (Вiopolymers and Cell, 2015)

D-Tyr-tRNATyr-deacylase (DTD) is a conservative enzyme, found in all domains of life, which ensures an additional checkpoint in the recycling of misaminoacylated D-Tyr-tRNATyr. DTD is capable of accelerating the hydrolysis ...
Colocalization of cortactin and PH domain of BCR in HEK293T cells and its potential role in cell signaling

Gurianov, D.S.; Antonenko, S.V.; Telegeev, G.D. (Вiopolymers and Cell, 2016)

Chromosomal translocation t(9;22)(q34;q11) leads to the generation of different types of the BCR-ABL fusion protein and cause different types of leukemias. The generated fusion proteins differ by the presence or absence ...
Comet assay application for determining genotoxicity of veterinary vaccines preparations

Dybkova, S.M.; Roman'ko, M.E.; Gruzina, T.G.; Rieznichenko, L.S.; Ulberg, Z.R.; Ushkalov, V.O.; Golovko, A.M. (Вiopolymers and Cell, 2010)

Aim. To study a possibility of usage of the alkaline gel electrophoresis method (Comet assay) for determination of genotoxic properties of veterinary vaccines preparations. Methods. The alkaline gel electrophoresis of ...
Detection of prostate specific ETS fusion transcripts in cancer samples

Mevs, L.V.; Gerashchenko, G.V.; Rosenberg, E.E.; Pikul, M.V.; Marynychenko, M.V.; Gryzodub, O.P.; Vozianov, S.O.; Stakhovsky, E.A.; Kashuba, V.I. (Вiopolymers and Cell, 2017)

Aim. To detect ETS fusion transcripts in Ukrainian population and to analyze a possible relationship between the ETS fusion transcripts and clinical characteristics of prostate cancer. Methods. Quantitative PCR (q-PCR) was ...
DNA loop organization in glioblastoma T98G cells at their different functional states

Afanasieva, K.S.; Semenova, A.Y.; Lukash, L.L.; Sivolob, A.V. (Вiopolymers and Cell, 2018)

The loop domain organization of chromatin, which plays an important role in transcription regulation, may depend on the cell functional state. Aim. To investigate DNA loop reorganization upon functional transitions in the ...
Effect of the vitamin D photosynthesis products on thermodynamic parameters of model lipid membranes

Kasian, N.A.; Vashchenko, O.V.; Gluhova, Ya.E.; Lisetski, L.N. (Вiopolymers and Cell, 2012)

Цель. Сравнить влияние провитамина D (ProD) и продуктов его фотои термоизомеризации, а также витамина D (VitD) на термодинамические параметры мультислоев гидратированного дипальмитоилфосфатидилхолина (ДПФХ). Методы. ...
Embryonically induced β-catenin haploinsufficiency attenuates postnatal heart development and causes violation of foetal genes program

Palchevska, O.L.; Balatskii, V.V.; Andrejeva, A.O.; Macewicz, L.L.; Piven, O.O.; Lukash, L.L. (Вiopolymers and Cell, 2013)

The β-catenin role in myocardium remodeling and hypertrophy development is the subject of numerous and controversial investigations. Aim. To investigate the significance of cardiac ablation of β-catenin for heart development ...
Expression and purification of full-length Alanyl-tRNA-synthetase from Thermus thermophilus HB27

Rybak, M.Yu.; Priss, A.E.; Gudzera, O.I.; Kovalchuk, A.O.; Kryklyvyi, I.A.; Tukalo, M.A. (Вiopolymers and Cell, 2018)

Aim. To gain insight into structural and functional properties of alanyl-tRNA,synthetase (AlaRS), we genetically engineered constructs for expression and purification of full-length AlaRS and checked its activity in ...

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