Иммуноцитогенетическая характеристика детей, страдающих сахарным диабетом I типа

dc.contributor.author	Ковалева, В.И.
dc.contributor.author	Будрейко, Е.А.
dc.contributor.author	Чумак, С.А.
dc.date.accessioned	2021-02-17T21:20:00Z
dc.date.available	2021-02-17T21:20:00Z
dc.date.issued	2014
dc.identifier.citation	Иммуноцитогенетическая характеристика детей, страдающих сахарным диабетом I типа / В.И. Ковалева, Е.А. Будрейко, С.А. Чумак // Фактори експериментальної еволюції організмів: Зб. наук. пр. — 2014. — Т. 14. — С. 204-207. — Бібліогр.: 15 назв. — рос.	uk_UA
dc.identifier.issn	2219-3782
dc.identifier.uri	http://dspace.nbuv.gov.ua/handle/123456789/178116
dc.description.abstract	Aims. The purpose of our study was to assess associative ability of acrocentric chromosomes (AC) in the peripheral blood lymphocytes of patients with type I diabetes mellitus. Methods. The analysis technique was performed according to the standard semimicromethod. Associations of acrocentric chromosomes (AAC) were assessed using D. Lang and E. Back (1968) criteria. Results. The results obtained have demonstrated that the number of activated T- lymphocytes with two AAC in children, suffering from type I diabetes, is 11.70 %, whereas in the population control this finding comes to 35.0 %. The average number of AAC per one cell in our patients was 2.19 less frequent than that in healthy age-matched persons and amounted to1.81 vs.3.97. Conclusions. The findings of our study indicate a lower associative ability of AC in probands with type I diabetes, which allows our authors to refer them to the persons with secondary immunodeficiency. Key words: type I diabetes mellitus, children, acrocentric chromosomes, associations.	uk_UA
dc.language.iso	ru	uk_UA
dc.publisher	Інститут молекулярної біології і генетики НАН України	uk_UA
dc.relation.ispartof	Фактори експериментальної еволюції організмів
dc.subject	Генетика людини та медична генетика	uk_UA
dc.title	Иммуноцитогенетическая характеристика детей, страдающих сахарным диабетом I типа	uk_UA
dc.title.alternative	Immunocytogenetic characteristics in children with type I diabetes mellitus	uk_UA
dc.type	Article	uk_UA
dc.status	published earlier	uk_UA
dc.identifier.udc	616.379 – 008.64 – 053.2 / 5: 575