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dc.contributor.author Ustinova, M.
dc.contributor.author Daneberga, Z.
dc.contributor.author Berzina, D.
dc.contributor.author Nakazawa-Miklasevica, M.
dc.contributor.author Maksimenko, J.
dc.contributor.author Gardovskis, J.
dc.contributor.author Miklasevics, E.
dc.date.accessioned 2019-01-23T18:26:37Z
dc.date.available 2019-01-23T18:26:37Z
dc.date.issued 2015
dc.identifier.citation Impact of KRAS variant rs61764370 on breast cancer morbidity / M. Ustinova, Z. Daneberga, D. Berzina, M. Nakazawa-Miklasevica, J. Maksimenko, J. Gardovskis, E. Miklasevics // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 292-294. — Бібліогр.: 7 назв. — англ. uk_UA
dc.identifier.issn 1812-9269
dc.identifier.uri http://dspace.nbuv.gov.ua/handle/123456789/145559
dc.description.abstract Low-penetrance gene variants and their combinations are topical study objects in breast cancer pathogenesis. Single nucleotide polymorphism rs61764370, localized in 3՛ UTR of KRAS gene, plays an important role in the development and progression of seve­ral cancers. The aim of our study was to determine the KRAS variant impact on breast cancer morbidity. Patients and Methods: 2214 patients diagnosed with breast cancer and 861 healthy controls were screened for KRAS variant by RFLP method. Available clinical data were collected and processed using statistical analysis methods. Results of present study suggest the KRAS variant impact on breast cancer development risk in premenopausal women, but it has no effect on breast cancer prognosis. We did not observe any KRAS variant effect on breast cancer patient 10-year disease-specific survival rates. Key Words: breast cancer, rs61764370, KRAS variant, predisposing factor. uk_UA
dc.description.sponsorship This study was funded by European Social Fund grant Nr. 2013/0047/1DP/1.1.1.2.0/13/APIA/VIAA/017. uk_UA
dc.language.iso en uk_UA
dc.publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України uk_UA
dc.relation.ispartof Experimental Oncology
dc.subject Short communications uk_UA
dc.title Impact of KRAS variant rs61764370 on breast cancer morbidity uk_UA
dc.type Article uk_UA
dc.status published earlier uk_UA


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