Наукова електронна бібліотека
періодичних видань НАН України

Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer

Репозиторій DSpace/Manakin

Показати простий запис статті

dc.contributor.author Melnikov, A.A.
dc.contributor.author Vasilyev, S.A.
dc.contributor.author Musabaeva, L.I.
dc.contributor.author Velikaya, V.V.
dc.contributor.author Gribova, O.V.
dc.contributor.author Startseva, Zh.A.
dc.contributor.author Urazova, L.N.
dc.contributor.author Lebedev, I.N.
dc.contributor.author Choynzonov, E.L.
dc.date.accessioned 2018-06-21T12:59:35Z
dc.date.available 2018-06-21T12:59:35Z
dc.date.issued 2012
dc.identifier.citation Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer / A.A. Melnikov, S.A. Vasilyev, L.I. Musabaeva, V.V. Velikaya, O.V. Gribova, Zh.A. Startseva, L.N. Urazova, I.N. Lebedev, E.L. Choynzonov // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 354-357. — Бібліогр.: 19 назв. — англ. uk_UA
dc.identifier.issn 1812-9269
dc.identifier.uri http://dspace.nbuv.gov.ua/handle/123456789/139878
dc.description.abstract Aim:To assess the frequency and spectrum of chromosome aberrations and micronuclei in peripheral blood lymphocytes of patients with parotid salivary gland tumors and relapse of breast cancer during the course of neutron therapy. Materials and Methods: Samples of peripheral blood were obtained from 9 patients with parotid salivary gland tumors (T3N0–3M0) and 8 patients with relapse of breast cancer before, after first fraction and at the end of neutron therapy. The treatment course specified 5.5–8.4 Gy (equivalent to 23–44 Gy of photon irradiation) with 1.3–2.2 Gy per fraction for patients with parotid salivary gland tumors and 4,8–8.0 Gy (equivalent to 30–40 Gy of photon irradiation) with 1.6 Gy per fraction for patients with relapse of breast cancer. Control group established for conventional cytogenetic analysis consisted of 15 healthy persons. Assessment of chromosome aberrations frequency was performed on routinely stained metaphase plates. Lymphocytes from the same patients were analyzed by micronucleus test in combination with fluorescent in situ hybridization (FISH) using pancentromeric DNA probe. Results: Level of chromosome aberrations and micronuclei significantly increased in lymphocytes of patients from both groups during neutron therapy (P < 0.05). This increase was mainly due to chromosome-type aberrations and centromere-negative micronuclei. The prevalent types of aberrations are in agreement with theoretical mechanisms of neutron effects on cells. Conclusion: Cytogenetic effects of fast neutron therapy in lymphocytes of patients with parotid salivary gland tumors and relapse of breast cancer were observed. A positive dynamics of radiation-induced chromosomal damages formation during the course was denoted in lymphocytes of cancer patients in both groups. uk_UA
dc.description.sponsorship The study is supported by the state contract № 16.512.11.2063 of Federal Target Research and Technology Program of the Ministry of Education and Science of Russian Federation, Federal Target Research Program “Scientific and scientific-educational personnel of innovative Russia (2009–2013)” (grant № 14.132.21.1319) and grant for young scientists of “OPTEC” company. uk_UA
dc.language.iso en uk_UA
dc.publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України uk_UA
dc.relation.ispartof Experimental Oncology
dc.subject Original contributions uk_UA
dc.title Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer uk_UA
dc.type Article uk_UA
dc.status published earlier uk_UA


Файли у цій статті

Ця стаття з'являється у наступних колекціях

Показати простий запис статті

Пошук


Розширений пошук

Перегляд

Мій обліковий запис