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Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression

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dc.contributor.author Cherdyntseva, N.V.
dc.contributor.author Gervas, P.A.
dc.contributor.author Litvyakov, N.V.
dc.contributor.author Stakcheeva, M.N.
dc.contributor.author Ponomaryeva, A.A.
dc.contributor.author Dobrodeev, A.Yu.
dc.contributor.author Denisov, E.V.
dc.contributor.author Belyavskaya, V.A.
dc.contributor.author Choinzonov, E.L.
dc.date.accessioned 2018-06-19T10:33:19Z
dc.date.available 2018-06-19T10:33:19Z
dc.date.issued 2010
dc.identifier.citation Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression / N.V. Cherdyntseva, P.A. Gervas, N.V. Litvyakov, M.N. Stakcheeva, A.A. Ponomaryeva, A.Yu. Dobrodeev, E.V. Denisov, V.A. Belyavskaya, E.L. Choinzonov // Experimental Oncology. — 2010. — Т. 32, № 3. — С. 205-208. — Бібліогр.: 23 назв. — англ. uk_UA
dc.identifier.issn 1812-9269
dc.identifier.uri http://dspace.nbuv.gov.ua/handle/123456789/138611
dc.description.abstract Aim: To examine the influence of combined genotypes of TP53 (exon 4, intron 3, intron 6) and XRCC1 (codon 10) on lung cancer age of onset. Methods: TP53 polymorphisms in codon 72 of exon 4 (Arg72Pro), in intron 3 (16 bp duplication), in intron 6 (G/A transition) and XRCC1 polymorphism in codon 10 (Arg399Gln) were analyzed in blood cells of 177 lung cancer patients and 196 healthy donors with Restriction Fragment Lenth Polymorphism PCR. Results: We showed that combination of TP53 variant genotypes and XRCC1 variant genotype is associated with the increased lung cancer risk in younger, but not elderly, smokers. In contrast, wild allele combination increases lung cancer risk for individuals over the age of 60. Conclusion: Our data confirm antagonistic pleiotropy hypothesis indicating that p53 protects the organism against cancer early in life, but promoting aging phenotype, including late life cancer in older persons. uk_UA
dc.description.sponsorship The research has been carried out with the support of the grants from Federal Special Purpose Program «Scientific and academic-teaching staff of innovative Russia» # P31 and # P256. uk_UA
dc.language.iso en uk_UA
dc.publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України uk_UA
dc.relation.ispartof Experimental Oncology
dc.subject Original contributions uk_UA
dc.title Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression uk_UA
dc.type Article uk_UA
dc.status published earlier uk_UA


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