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Kinase suppressor of Ras 2 is involved in regulation of cell proliferation and is up-regulated in human invasive ductal carcinomas of breast

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dc.contributor.author Jia, M.
dc.contributor.author Souchelnytskyi, S.
dc.date.accessioned 2018-06-19T10:30:30Z
dc.date.available 2018-06-19T10:30:30Z
dc.date.issued 2010
dc.identifier.citation Kinase suppressor of Ras 2 is involved in regulation of cell proliferation and is up-regulated in human invasive ductal carcinomas of breast / M. Jia, S. Souchelnytskyi // Experimental Oncology. — 2010. — Т. 32, № 3. — С. 209-212. — Бібліогр.: 12 назв. — англ. uk_UA
dc.identifier.issn 1812-9269
dc.identifier.uri http://dspace.nbuv.gov.ua/handle/123456789/138608
dc.description.abstract Aim: To study the expression of Kinase Suppressor of Ras 2 (KSR2) in human breast tumors and its effect on proliferation of breast epithelial cells. We reported previously that KSR2 was up-regulated in immortalized human breast epithelial cells. Methods: Proteomics technologies, systems biology tool for a KSR2 network analysis, immunoblotting, siRNA technology, overexpression of KSR2, cell proliferation assays and immunohistochemistry of tissue microarray of human breast tumors and normal breast tissue were used. Results: In conditionally immortalized primary epithelial cells KSR2 expression was shown to be up-regulated. The involvement of KSR2 in regulation of cell proliferation was predicted by a KSR2-centered network analysis. We observed that KSR2 down-regulation with specific siRNA inhibited cell proliferation. By immunohistochemistry of tissue microarray it was demon strated that KSR2 expression was enhanced in human invasive breast carcinomas. Conclusion: Our findings propose KSR2 as a new marker of immortalization, which has an impact on cell proliferation. uk_UA
dc.description.sponsorship We are grateful to Carina Hellberg for advice on immunohistochemistry. This work is supported in part by grants from the programmes of the Dept. of Oncology-Pathology, Karolinska Institutet, Ludwig Institute for Cancer Research, the Swedish Cancer Society, the Swedish Research Council, the Swedish Institute, the EU program RTN «EpiPlastCarcinoma», INTAS, UICC/American Cancer Society, Hiroshima University and Merck KGaA to S.S. uk_UA
dc.language.iso en uk_UA
dc.publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України uk_UA
dc.relation.ispartof Experimental Oncology
dc.subject Original contributions uk_UA
dc.title Kinase suppressor of Ras 2 is involved in regulation of cell proliferation and is up-regulated in human invasive ductal carcinomas of breast uk_UA
dc.type Article uk_UA
dc.status published earlier uk_UA


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