Наукова електронна бібліотека
періодичних видань НАН України
періодичних видань НАН України
Influence of two pt(iv) complexes on viability, apoptosis and cell cycle of B16 mouse melanoma tumors
Репозиторій DSpace/Manakin
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| dc.contributor.author | Kaznica, A. | |
| dc.contributor.author | Drewa, T. | |
| dc.contributor.author | Lakomska, I. | |
| dc.contributor.author | Ryta-Stamirowska, P. | |
| dc.contributor.author | Debski, R. | |
| dc.contributor.author | Styczynski, J. | |
| dc.contributor.author | Drewa, G. | |
| dc.contributor.author | Szłyk, E. | |
| dc.date.accessioned | 2018-06-14T15:40:56Z | |
| dc.date.available | 2018-06-14T15:40:56Z | |
| dc.date.issued | 2009 | |
| dc.identifier.citation | Influence of two pt(iv) complexes on viability, apoptosis and cell cycle of B16 mouse melanoma tumors / A. Kaznica, T. Drewa, I. Lakomska, P. Ryta-Stamirowska, R. Debski, J. Styczynski, G. Drewa, E. Szłyk // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 33–36. — Бібліогр.: 19 назв. — англ. | uk_UA |
| dc.identifier.issn | 1812-9269 | |
| dc.identifier.uri | http://dspace.nbuv.gov.ua/handle/123456789/135114 | |
| dc.description.abstract | Several platinum(IV) complexes are showing considerable promise in initial trials, producing reactive intermediates that then interact with DNA. Aim: To perform in vitro study of two new platinum(IV) complexes cytotoxic effect on B16 mouse melanoma cells. Methods: PtCl₄ (dbtp)₂ and PtCl₂ (6mp)₂ complexes were prepared. PtCl₄ (dbtp)₂ was created as modification of PtCl₄ (dmtp) test previously.Apoptosis and necrosis were examined using flow cytometry, upon Annexin V/PI staining. Results: LC₁₀,LC₅₀ andLC₉₀ parameters established for PtCl₄ (dbtp)₂ were as following: 2.6, 17.0, 58.0 μmol/L. However LC₁₀ andLC₅₀ established for PtCl₂ (6mp)₂ were 1.2 and 14.0μmol/l respectively. The both complexes induced apoptosis. PtCl₂ (6mp)₂ induced cell cycle arrest in G0/G1, while PtCl₄ (dbtp)₂ — in S-phase. Conclusions: PtCl₄ (dbtp)₂ appeared to be more cytotoxic against B16 cells than PtCl₂ (6mp)₂ . Apoptosis was the main mechanism of cell loss in cultures incubated with both tested complexes. | uk_UA |
| dc.description.sponsorship | Financial support from Nicolaus Copernicus University grant 551/Ch-CM is greatly acknowledged. | uk_UA |
| dc.language.iso | en | uk_UA |
| dc.publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України | uk_UA |
| dc.relation.ispartof | Experimental Oncology | |
| dc.subject | Original contributions | uk_UA |
| dc.title | Influence of two pt(iv) complexes on viability, apoptosis and cell cycle of B16 mouse melanoma tumors | uk_UA |
| dc.type | Article | uk_UA |
| dc.status | published earlier | uk_UA |
