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Experimental Oncology, 2014 (том 36)
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Перегляд Experimental Oncology, 2014 (том 36) за темою

Перегляд Experimental Oncology, 2014 (том 36) за темою "Original contributions"

Результати 1-20 з 38

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Baseline serum levels of multiple cytokines and adhesion molecules in patients with acute myeloid leukemia: results of a pivotal trial

Kupsa, T.; Vasatova, M.; Karesova, I.; Zak, P.; Horacek, J.M. (Experimental Oncology, 2014)

Aim: Evaluation of serum levels of 17 cytokines and 5 adhesion molecules in patients with newly diagnosed acute myeloid leukemia (AML) using biochip array technology. We searched for links between baseline levels and age, ...
Clinical significance of hormonal receptor status of malignant ovarian tumors

Tkalia, I.G.; Vorobyova, L.I.; Svintsitsky, V.S.; Nespryadko, S.V.; Goncharuk, I.V.; Lukyanova, N.Y.; Chekhun, V.F. (Experimental Oncology, 2014)

Objectives: To study hormonal receptor status (HRS) of malignant ovarian tumors (MOT) and determine its clinical significance. Patients and Methods: Retrospective analysis of case histories of 284 patients with MOT of ...
Comprehensive analysis of intratumoral lymphocytes and FOXP3 expression in tumor cells of endometrial cancer

Lurchenko, N.P.; Glushchenko, N.M.; Buchynska, L.G. (Experimental Oncology, 2014)

Aim: To study the tumor microenvironment (CD4⁺, CD8⁺ and FOXP3⁺ lymphocytes) and FOXP3 expression by tumor cells and correlation of studied parameters with clinical and morphological characteristics of endometrial ...
Correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer

Zuikov, S.A.; Borzenko, B.G.; Shatova, O.P.; Bakurova, E.M.; Polunin, G.E. (Experimental Oncology, 2014)

Aim: To examine the relationship between metabolic features of purine nucleotides and antioxidant system depending on the age of patients with colorectal cancer. Materials and Methods: The activity of adenosine deaminase, ...
Destabilization of human cell genome under the combined effect of radiation and ascorbic acid

Domina, E.A.; Pylypchuk, O.P.; Mikhailenko, V.M. (Experimental Oncology, 2014)

The aim of this study was to investigate peculiarities of ascorbic acid effect on radiation-induced chromosomal aberrations frequency and range in the cultured peripheral blood lymphocytes (PBL) of healthy donors and cancer ...
Determination of the optimal chemotherapy drugs pretreatment time through cultivation of hemopoietic cells in CML-patients treated with tyrosine kinase inhibitors

Zhaleiko, I.O.; Perekhrestenko, T.P.; Bilko, D.I.; Dyagil, I.S.; Bilko, N.M. (Experimental Oncology, 2014)

Background: Targeted therapy drugs, including imatinib, are used for inhibiting the marker oncoprotein of chronic myeloid leukemia — BCR-ABL tyrosine kinase. However, in some patients the drug resistance can emerge too ...
Dynamics of changes of antioxidant system indexes during the growth of two Lewis lung carcinoma variants

Pyaskovskaya, O.N.; Sorokina, L.V.; Kolesnik, D.L.; Boichuk, I.V.; Melnikov, O.R.; Solyanik, G.I. (Experimental Oncology, 2014)

Aim: To study an intensity of prooxidant processes and activity of antioxidant enzymes in tumor tissue of two Lewis lung carcinoma variants (LLC and LLC/R9) differing by their proliferative, metastatic, and angiogenic ...
Elucidating the roles of miR-372 in cell proliferation and apoptosis of nasopharyngeal carcinoma TW01 cells

Tan, J.K.; Tan, E.L.; Gan, S.Y. (Experimental Oncology, 2014)

Aim: Deregulation of microRNA has been associated with cancer progression and the modification of cancer phenotypes could be achieved by targeting microRNA expression. This study aimed to determine the effects of miR-372 ...
Expression of human beta-defensins-1–4 in thyroid cancer cells and new insight on biologic activity of hBD-2 in vitro

Zhuravel, O.V.; Gerashchenko, O.L.; Khetsuriani, M.R.; Soldatkina, M.A.; Pogrebnoy, P.V. (Experimental Oncology, 2014)

The study was aimed on analysis of human beta-defensin-1–4 (hBDs) mRNA expression in cultured thyroid cancer cells and evaluation of effects of recombinant hBD-2 (rec-hBD-2) on growth patterns, migration properties and ...
FGFR3 and TP53 mutations in a prospective cohort of Belarusian bladder cancer patients

Smal, M.P.; Rolevich, A.I.; Polyakov, S.L.; Krasny, S.A.; Goncharova, R.I. (Experimental Oncology, 2014)

Aim: The aim of this study was to determine the frequencies of FGFR3 and TP53 mutations in a prospective cohort of 150 bladder cancer patients and to assess the relationship between their mutational status and clinicopathological ...
Fluorescent diagnosis and photodynamic therapy for C6 glioma in combination with antiangiogenic therapy in subcutaneous and intracranial tumor models

Tzerkovsky, D.A.; Osharin, V.V.; Istomin, Y.P.; Alexandrova, E.N.; Vozmitel, M.A. (Experimental Oncology, 2014)

Objective: Investigating the distinctions pharmacokinetics of chlorin e6 conjugated with polyvinyl pyrrolidone photosensitizer (Ce6CPPPS)in healthy and tumor tissues of rat brain and evaluating the antitumor efficacy of ...
Growth inhibitory and adjuvant therapeutic potential of aqueous extract of Triticum aestivum on MCF-7 and HeLa cells

Hussain, A.; Gheewala, T.M.; Vas, A.J.; Shah, K.; Goala, P.; Khan, S.; Hinduja, S.; Sharma, C. (Experimental Oncology, 2014)

Aim: The purpose of the present study is to evaluate the potent growth inhibitory effects of aqueous wheatgrass extract (AWE) alone and in combination with cisplatin on human breast and cervical cancer cells. Materials and ...
Hypoxia enhances antitumor activity of dichloroacetate

Kolesnik, D.L.; Pyaskovskaya, O.N.; Boichuk, I.V.; Solyanik, G.I. (Experimental Oncology, 2014)

It is known that glycolysis contributes to the survival of tumor cells by providing them with energetic and plastic substrates. Dichloroacetate (DCA) as inhibitor of kinase pyruvate dehydrogenase shifts balance of energy ...
Impact of combinations of EGF, TGFβ, 17β-oestradiol, and inhibitors of corresponding pathways on proliferation of breast cancer cell lines

Mints, M.; Souchelnytskyi, S. (Experimental Oncology, 2014)

Aim: The impact of combinations of anti-cancer drugs and growth factors on tumour cells may differ from the assumed sum of the effects of each factor separately. Therefore it is important to study the effects of different ...
Impact of stromal cell components of tumor microenvironment on epithelial-mesenchymal transition in breast cancer cells

Bezdenezhnykh, N.; Semesiuk, N.; Lykhova, O.; Zhylchuk, V.; Kudryavets, Y. (Experimental Oncology, 2014)

Background: Cell and tissue homeostasis results from the dynamic balance of cell – cell and cell – extracellular component crosstalk that regulates proliferation, differentiation, and apoptosis of cells as well as secretion ...
Increase of antitumor activity of cisplatin using agonist of gonadotropin-realising hormone and inhibitor of aromatase on the model of ascites ovarian tumor

Tkalia, I.G.; Vorobyova, L.I.; Grabovoy, A.N.; Svintsitsky, V.S.; Tarasova, T.О.; Lukyanova, N.Y.; Todor, I.N.; Chekhun, V.F. (Experimental Oncology, 2014)

Aim : To study antitumor activity of triptorelin — agonist of gonadotropin-releasing hormone and exemestane — inhibitor of aromatase in monotherapy and in combination with cisplatin on the model of receptor-positive for ...
Intrinsic defect in B-lymphoblastoid cell lines from patients with X-linked lymphoproliferative disease type 1. I. Cell surface phenotype and functional studies

Shlapatska, L.M.; Kovalevska, L.M.; Gordiienko, I.M.; Sidorenko, S.P. (Experimental Oncology, 2014)

Background: Mutations in SH2D1A/DSHP/SAP gene are responsible for the onset of X-linked lymphoproliferative disease type 1 (XLP1) that have increased risk for B-cell lymphoma development. In XLP1 patients SAP deficient NK, ...
Intrinsic defect in B-lymphoblastoid cell lines from patients with X-linked lymphoproliferative disease type 1. II. Receptor-mediated Akt/PKB and ERK1/2 activation and transcription factors expression profile

Shlapatska, L.M.; Kovalevska, L.M.; Gordiienko, I.M.; Sidorenko, S.P. (Experimental Oncology, 2014)

Background: X-linked lymphoproliferative disease type 1 (XLP1) belongs to genetically determined primary immunodeficiency syndromes with mutations in SH2D1A/DSHP/SAP gene. The dramatic increase of the risk of B-cell lymphoma ...
Involvement of human beta-defensin-2 in regulation of malignant potential of cultured human melanoma cells

Gerashchenko, O.; Zhuravel, E.; Skachkova, O.; Khranovska, N.; Pushkarev, V.; Pogrebnoy, P.; Soldatkina, M. (Experimental Oncology, 2014)

Background and Aim: Human beta-defensin-2 (hBD-2) is an antimicrobial cationic peptide capable to control human carcinoma cell growth via cell cycle regulation. The present study was aimed on determination of hBD-2 influence ...
Number of Langerhans cells is decreased in premalignant keratosis and skin cancers

Shevchuk, Z.; Filip, A.; Shevchuk, V.; Kashuba, E. (Experimental Oncology, 2014)

Background: It was shown earlier that a number of CD207 positive Langerhans cells was lower in basal cell carcinomas than in the normal epidermis. Moreover, benign skin lesions presented a higher number of Langerhans cells ...

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Перегляд Experimental Oncology, 2014 (том 36) за темою "Original contributions"

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Перегляд Experimental Oncology, 2014 (том 36) за темою "Original contributions"

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