Наукова електронна бібліотека
періодичних видань НАН України
періодичних видань НАН України
Precision therapy to target apoptosis in prostate cancer
Репозиторій DSpace/Manakin
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Precision therapy to target apoptosis in prostate cancer
Тема:
Reviews
Посилання:
Precision therapy to target apoptosis in prostate cancer / G. Kulik // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 226-230. — Бібліогр.: 48 назв. — англ.
Підтримка:
This work was supported by Internal Research Grant (IRG2014 Project number 4071101011411) from Alfaisal University. The author is grateful to Karen Klein (Biomedical Research Services and Administration, Wake Forest University Health Sciences) for manuscript editing.
Дата:
2014
Переглядів:
513
Завантажень:
149
Анотація:
Androgen-independent prostate cancer shows limited response to existing systemic therapies. Recent advances in prostate-selective targeting of small molecule inhibitors and bacterial toxins have created opportunities to design a new generation of therapies for advanced prostate cancer. Yet prioritizing targets for these therapies remain challenging, since multiple mechanisms contribute to the pathophysiology of androgen-independent prostate cancer. This review explores the possibility of targeting the apoptosis regulatory network as most direct approach to efficient treatment of advanced androgen-independent prostate cancer. Key Words: prostate cancer, apoptosis, prostate-selective therapies, PSA-activated pro-drugs, PSMA-targeting toxins.
