Наукова електронна бібліотека
періодичних видань НАН України
періодичних видань НАН України
The phenomenon of multi-drug resistance in the treatment of malignant tumors
Репозиторій DSpace/Manakin
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The phenomenon of multi-drug resistance in the treatment of malignant tumors
Тема:
Reviews
Посилання:
The phenomenon of multi-drug resistance in the treatment of malignant tumors / S.V. Vtorushin, K.Y. Khristenko, M.V. Zavyalova, V.M. Perelmuter, N.V. Litviakov, E.V. Denisov, A.Y. Dulesova, N.V. Cherdyntseva // Experimental Oncology. — 2014. — Т. 36, № 3. — С. 144-156. — Бібліогр.: 191 назв. — англ.
Підтримка:
The study is supported by the grants № 14–04– 31727/14 and № 13–04–98111 r_Sibir_a of Russian Foundation of Basic Research (RFBR) and Grant of the President of the Russian Federation (agreement 14.122.13.491-MD).
Дата:
2014
Переглядів:
655
Завантажень:
224
Анотація:
Multi-drug resistance (MDR) is a condition when there is broad cross-resistance of cells to various agents which are different in structure and effect. Modern perceptions on mechanisms of MDR development in malignant tumors have been considered, in particular, in treating breast cancer. Physiological functions and contribution to MDR development of ABC-transporter protein families have been described. The role of activation of glutathione system enzymes and apoptosis-regulating proteins in MDR formation has been shown. Key Words: multi-drug resistance, ABC-transporters, glutathione system, apoptosis-controlling genes.
