Посилання:Optimization of surface plasmon resonance based biosensor for clinical diagnosis of the Epstein–Barr herpes virus disease / R.V. Khrystosenko // Semiconductor Physics Quantum Electronics & Optoelectronics. — 2016. — Т. 19, № 1. — С. 84-89. — Бібліогр.: 19 назв. — англ.
Підтримка:The author would like to thank the employees of D. Zabolotny Institute of Microbiology and Virology of NAS of Ukraine: N.V. Nesterova, S.D. Zagorodnya, G.V. Baranova, A.V. Golovan, and the employees of V. Lashkaryov Institute of Semiconductor Physics of NAS of Ukraine Yu.V. Ushenin and A.V. Samoylov for their assistance in performing this work. This work was supported by the National Academy of Sciences of Ukraine through the project “Pilot operation and metrological support diagnostic instrument based on surface plasmon resonance for the diagnosis of herpes virus. Design and manufacture of sensing elements, electronic, mechanical and software modules devices based on surface plasmon resonance”.
The influence of the sensitive element fabrication technology and noise performance of surface plasmon resonance (SPR) immunosensor on sensitivity and stability of operation inherent to the “Plasmon” series instrument has been investigated to improve reliability of diagnosis and treatment of the Epstein–Barr herpes virus disease. To minimize the effect of the temperature change induced noise, compensation (introduction of the reference channel) and stabilization (active thermal control) methods were applied, allowing to substantially enhance resolution of the used SPR sensor system.