Перегляд за автором "Buchynska, L.G."

Результати 1-14 з 14

Analysis of P53, P16INK4A, PRB and cyclin D1 expression and human papillomavirus in primary ovarian serous carcinoma

Bilyk, O.O.; Pande, N.T.; Buchynska, L.G. (Experimental Oncology, 2011)

Aim: To evaluate the prognostic relevance of key cell cycle regulatory proteins p53, p16INK4a, pRb and Cyclin D1 expression, the presence of high risk HPVs and their association with clinicopathological parameters and the ...
Comprehensive analysis of intratumoral lymphocytes and FOXP3 expression in tumor cells of endometrial cancer

Lurchenko, N.P.; Glushchenko, N.M.; Buchynska, L.G. (Experimental Oncology, 2014)

Aim: To study the tumor microenvironment (CD4⁺, CD8⁺ and FOXP3⁺ lymphocytes) and FOXP3 expression by tumor cells and correlation of studied parameters with clinical and morphological characteristics of endometrial ...
DNA damage in tumor cells and peripheral blood lymphocytes of endometrial cancer patients assessed by the comet assay

Buchynska, L.G.; Brieieva, O.V.; Lurchenko, N.P.; Protsenko, V.V.; Nespryadko, S.V. (Experimental Oncology, 2017)

To date, genome instability is considered to be a common feature not only of tumor cells, but also of non-malignant cells of cancer patients, including peripheral blood lymphocytes (PBLs). The issue of the association ...
Expression OF p53, p21WAF1/CIP1 , p16INK4A and Ki-67 proteins in serous ovarian tumors

Buchynska, L.G.; Nesina, I.P.; Yurchenko, N.P.; Bilyk, O.O.; Grinkevych, V.N.; Svintitsky, V.S. (Experimental Oncology, 2007)

Aim: The analysis of p53, p21WAF1/CIP1, p16INK4a and Ki-67 expression in serous ovarian carcinomas of different grade. Materials and Methods: In total, 43 ovarian adenocarcinomas and 8 non-altered ovarian epithelial tissues ...
Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers

Buchynska, L.G.; Iurchenko, N.P.; Grinkevych, V.M.; Nesina, I.P.; Chekhun, S.V.; Svintsitsky, V.S. (Experimental Oncology, 2009)

Aim: To study the expression of estrogen receptors (ER) and progesterone receptors (PR) and proliferation marker Ki-67 in ovarian tumors using immunohistochemistry, and evaluate possible prognostic significance ofthese ...
FOXP3 gene promoter methylation in endometrial cancer cells

Buchynska, L.G.; Iurchenko, N.P.; Verko, N.P.; Nekrasov, K.A.; Kashuba, V.I. (Experimental Oncology, 2015)

Aim: To determine the methylation level of promoter region of the FOXP3 gene promoter depending on the heterogeneity of intracellular localization of its protein product in endometrial cancer (EC) cells and assess its ...
Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma

Nesina, I.P.; Iurchenko, N.P.; Buchynska, L.G. (Experimental Oncology, 2018)

Aim: To study the expression of adhesion markers (E-cadherin, β-catenin and vimentin) associated with epithelial-mesenchymal transition (EMT) and their role in progression of endometrial carcinoma (EC). Materials and ...
Phenotypic features of endometrial tumors in patients with family history of cancer

Buchynska, L.G.; Lurchenko, N.P.; Glushchenko, N.M.; Nesina, I.P. (Experimental Oncology, 2017)

Aim: To determine the peculiarities of expression of a number of proteins-regulators of the cell cycle in endometrial cancer (EC) cells in patients with a family history of oncological pathologies. Patients and Methods: ...
Risk assessment of cancer of the female reproductive system

Glushchenko, N.M.; Nesina, I.P.; Lurchenko, N.P.; Proskurnya, L.A.; Buchynska, L.G. (Experimental Oncology, 2014)

Aim: To create an information resource concerning multifactorial oncological diseases of the female reproductive system. Materials and Methods: A comprehensive search of the literature in the PubMed and Ukrainian scientific ...
Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients

Buchynska, L.G.; Brieieva, O.V. (Experimental Oncology, 2018)

Background: The development of hormone-dependent cancers, including endometrial carcinomas, in great part may be mediated by the genotoxic effects of estrogen metabolites, among which 4-hydroxyestradiol (4OHE2) is characterized ...
Significance of ferritin expression in formation of malignant phenotype of human breast cancer cells

Chekhun, S.V.; Lukyanova, N.Y.; Shvets, Y.V.; Burlaka, A.P.; Buchynska, L.G. (Experimental Oncology, 2014)

Aim: The aim of our study is to investigate the disorders of ferritin functioning in breast cancer (BC) cells of different molecular subtype. Materials and Methods: The cell lines used in the analysis include T47D, MCF-7, ...
The frequency of human papilloma virus types 16, 18 in upper genital tract of women at high risk of developing ovarian cancer

Bilyk, O.O.; Pande, N.T.; Pejovic, T.; Buchynska, L.G. (Experimental Oncology, 2014)

Aim: To investigate the incidence of human papilloma virus (HPV) types 16, 18 in upper genital tract of women considered at a high risk (HR) of developing epithelial ovarian cancer (EOC). Methods: HPV 16 and 18 E6 ORF ...
The study of chromosomal instability in patients with endometrial cancer

Nesina, I.P.; Lurchenko, N.P.; Nespryadko, S.V.; Buchynska, L.G. (Experimental Oncology, 2014)

Aim: Study is devoted to evaluation of sensitivity of peripheral blood T-lymphocytes (PBL) of patients with endometrial cancer (EC) to genotoxic effect of bleomycin and detection of patients with hidden chromosomal ...
The study of mismatch repair in endometrial cancer patients with a family history of cancer

Buchynska, L.G.; Brieieva, O.V.; Nekrasov, K.A.; Nespryadko, S.V. (Experimental Oncology, 2015)

Aim: To assess the expression of mismatch repair (MMR) proteins MSH2 and MLH1 and carry out microsatellite analysis in patients with endometrial cancer (EC) with regard to the family history of cancer. Materials and Methods: ...

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Перегляд за автором "Buchynska, L.G."

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