Перегляд за темою "Biomedicine"

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13q Deletions detected by fluorescence in situ hybridization for diagnosis and prognosis of chronic lymphoproliferative neoplasms

Sitko, V.V.; Misharina, J.A.; Minchenko, J.M.; Poluben, L.O.; Dmitrenko, O.O.; Silaiev, Y.O.; Kostyukova, N.I.; Tkachenko, O.V.; Tovstogan, A.O.; Polyanska, V.M.; Lyashenko, L.O.; Bebeshko, V.G. (Вiopolymers and Cell, 2015)

Aim. Determination of deletion of the long arm of chromosome 13 in the patients with chronic lymphocytic leukemia, diffuse large B-cell lymphoma and multiple myeloma to provide prognostic assessments of Chronic Lymphoproliferative ...
Aberrant expression of metallothioneins in clear cell renal cell carcinomas

Rymar, V.I.; Lototskaya, L.V.; Kondratov, O.G.; Stakhovsky, E.O.; Kononenko, O.A.; Kashuba, V.I. (Вiopolymers and Cell, 2015)

Aim. To find candidate tumor suppressor genes among metallothioneins for clear cell renal cell carcinoma. Methods. Analysis of the microarray data, quantitative PCR. Results. We found three genes encoding metallothioneines ...
Analysis of mutations in GBA gene in Ukrainian patients with Gaucher disease

Olkhovych, N.V.; Nedoboy, A.M.; Pichkur, N.O.; Gorovenko, N.H. (Вiopolymers and Cell, 2017)

Gaucher disease (MIM 230800) is the most common storage disorder, caused by hereditary deficiency of the lysosomal enzyme of glucocerebrosidase (EC 3.2.1.45). Human glucocerebrosidase gene (GBA) is mapped to the 1q21 locus, ...
Association between the PSMB5 and PSMC6 genetic variations and children obesity in the Latvian population

Paramonova, N.; Kupca, S.; Rumba-Rozenfelde, I.; Sjakste, N.; Sjakste, T. (Вiopolymers and Cell, 2014)

According to the recent data the ubiquitin-proteasome system (UPS) is implicated in the pathogenesis of obesity. Aim of our study was to evaluate a possible association between genetic variations in the PSMB5 and PSMC6 ...
Association of allelic polymorphisms of the Matrix Gla-protein system genes with acute coronary syndrome in the Ukrainian population

Garbuzova, V.Yu.; Stroy, D.A.; Dosenko, V.E.; Obukhova, O.A.; Atama, O.V. (2015)

Calcification of the vascular wall is a prognostic factor for the outcome of acute coronary syndrome (ACS). Matrix Gla-protein system, which includes MGP, VDR, VKOR, GGCX, BMP-2 is an important factor in vessels protection ...
Association of genetic polymorphism with the mutation status of the BRCA1/2 genes in spontanous breast cancer

Polinyk, S.I.; Rybchenko, L.A.; Klymenko, S.V.; Zaharceva, L.M.; Klimuk, B.T. (Вiopolymers and Cell, 2017)

Aim. To study ssociation of the FGFR2 and TOX3/LOC643714 genetic polymorphisms with the BRCA1/2 mutation status in Ukrainian female breast cancer patients without ionizing radiation impact in their histories. Methods. ...
Association of genotypes by polymorphic variant C-108T of PON1 gene with the risk of developing breast cancer and hypertensive disease in women

Fishchuk, L.Ye. (Вiopolymers and Cell, 2014)

Aim. To analyze the effect of the polymorphic variant C-108T of PON1 gene on the risk of developing breast cancer (BC) and hypertensive disease (HD) in women. Methods. 130 women with non-complicated HD of degree II and 131 ...
Association of IL8 and IL10 gene allelic variants with ischemic stroke risk and prognosis

Kucherenko, A.M.; Shulzhenko, D.V.; Kuznetsova, S.M.; Demydov, S.V.; Livshits, L.A. (Вiopolymers and Cell, 2014)

Aim. Evaluating a role of IL8 gene –781 C/T, and IL10 gene –592C/A polymorphisms as genetic markers of ischemic stroke risk. Methods. A case group consisted of 183 patients with ischemic stroke, which were ...
Association of the EPHA1 gene polymorphism with idiopathic mild intellectual disability

Gulkovskyi, R.V.; Livshits, L.A.; Sivolob, A.V. (Вiopolymers and Cell, 2015)

Aim. To investigate a possible association of the EPHA1 gene polymorphism with mild intellectual disability (ID). Methods. The group of patients with mild (IQ score between 50 and 70) idiopathic intellectual disability ...
Association of the leukemia inhibitory factor gene polymorphism rs929271 with idiopathic mild intellectual disability

Gulkovskyi, R.V.; Volkova, L.S.; Livshits, L.A. (2015)

Aim. To investigate the possible association of LIF gene polymorphism rs929271 with mild intellectual disability (ID). Methods. The group of patients with mild (IQ score between 50 and 70) idiopathic intellectual disability ...
Autoantibodies against tyrosyl-tRNA synthetase and its separated domains at essential hypertension

Grom, M.Yu.; Yakovenko, L.F.; Granich, V.M.; Dobrohod, A.S.; Torbas, O.O.; Radchenko, A.D.; Sirenko, Yu.M.; Sidorik, L.L.; Kornelyuk, A.I. (Вiopolymers and Cell, 2015)

In addition to the key role in biosynthesis some aminoacyl-tRNA synthetases provide non-canonical functions. Particularly, separated fragments of tyrosyl-tRNA synthetase (TyrRS) involved into angiogenesis and inflammation. ...
Chromosomal aberrations in spontaneously aborted products of conception from Ukraine

Tkach, I.R.; Huleyuk, N.L.; Zastavna, D.V.; Weise, A.; Liehr, T.; Ciszkowicz, E.; Tyrka, M. (Вiopolymers and Cell, 2017)

Aim. To investigate peculiarities of numerical chromosomal imbalances in spontaneous products of conception from Western region of Ukraine. Methods. GTG-banding, interphase mFISH with probe panels for chromosomes 13/21, ...
Cisplatin treatment of C6 rat glioma in vivo did not influence copy number alterations and growth pattern of tumor-derived resistant cells

Stepanenko, A.A.; Baklaushev, V.P.; Vassetzky, Y.S.; Dmitrenko, V.V. (Вiopolymers and Cell, 2015)

Aim. To investigate whether the cisplatin treatment of C6 rat glioma in vivo impacts the copy number alterations (CNAs), proliferation and colony formation efficiency (CFE) of tumor-derived cisplatin-resistant cells. ...
Comparative analysis of epigenetic markers in plasma and tissue of patients with colorectal cancer

Kondratov, A.G.; Nekrasov, K.A.; Lototska, L.V.; Panasenko, G.V.; Stoliar, L.A.; Lapska, Y.V.; Kolesnyk, O.O.; Shchepotin, I.B.; Rynditch, A.V.; Kashuba, V.I. (Вiopolymers and Cell, 2014)

Aim. The work is devoted to the development of less invasive tools for the colorectal cancer (CRC) screening. Methods. Q-PCR and methylation-specific PCR techniques were used in the current work. Results. We have shown ...
Comparison of dual acting drugs and conventional NSAIDs towards parameters of NO-synthase system and oxidative stress in mucosal membrane of large intestine of rats with experimental ulcerative colitis

Sklyarov, A.Ya.; Lesyk, R.B.; Panasyuk, N.B.; Fomenko, I.S.; Havrylyuk, D.Ya. (Вiopolymers and Cell, 2011)

Aim was to compare the action of 2A5DHT compound (dual COX-2/5-LOX inhibitor) and conventional non-steroidal anti-inflammatory drugs towards parameters of nitric oxide (NO) system and intensity of oxidative stress in the ...
Contribution of chromosomal abnormalities and genes of the major histocompatibility complex to early pregnancy losses

Tkach, I.R.; Sosnina, K.O.; Huleyuk, N.L.; Terpylyak, O.I.; Zastavna, D.V.; Weise, A.; Kosyakova, N.; Liehr, T. (2015)

Aim. The determination of chromosomal abnormalities in samples from early pregnancy losses and allelic polymorphism of HLA–DRB1 and DQA1 genes in couples with recurrent miscarriage. Methods. Banding cytogenetic and interphase ...
Detection of V617F mutation of gene jak2 at patients with chronic myeloproliferative neoplasms

Dybkov, M.V.; Gartovska, I.R.; Maliuta, S.S.; Telegeev, G.D. (Вiopolymers and Cell, 2010)

The aim of the work was to create a protocol for detecting the V617F mutation of the gene jak2 in samples of patients with chronic myeloproliferative neoplasm which is necessary to unify the procedures of the analysis of ...
Development of ARMS PCR tests for detection of common CFTR gene mutations

Soloviov, O.O.; Pampukha, V.M.; Livshits, L.A. (Вiopolymers and Cell, 2010)

Aim. To develop diagnostic assays, based on the amplification refractory mutation system (ARMS) principle, for detection of common mutations in the CFTR gene using two approaches: standard PCR with further gel-electrophoresis ...
Effect of anticancer drugs on breast cancer cells sensitive and resistant to doxorubicin: expression of mRNAs of TGF-β and its receptors

Chorna, I.V.; Fedorenko, O.V.; Stoika, R.S. (Вiopolymers and Cell, 2014)

Aim. Comparative study of the effect of chemotherapeutic drugs (doxorubicin, methotrexate and cisplatin) and TGF-β on the human breast carcinoma MCF-7 cells, sensitive (wt) and resistant (DOX/R) to the doxorubicin action. ...
Efficiency of application of different DNA probes in identifying marker chromosomes

Tavokina, L.V.; Brovko, A.O.; Baronova, E.V.; Moskalenko, E.P.; Gorovenko, N.G. (Вiopolymers and Cell, 2016)

The presence of marker chromosomes in the human karyotype always requires a special diagnostic approach. Determination of the marker chromosome type and structure is of great diagnostic and prognostic importance. There are ...

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