Перегляд за автором "Lesyk, R.B."

Результати 1-10 з 10

Comparison of dual acting drugs and conventional NSAIDs towards parameters of NO-synthase system and oxidative stress in mucosal membrane of large intestine of rats with experimental ulcerative colitis

Sklyarov, A.Ya.; Lesyk, R.B.; Panasyuk, N.B.; Fomenko, I.S.; Havrylyuk, D.Ya. (Вiopolymers and Cell, 2011)

Aim was to compare the action of 2A5DHT compound (dual COX-2/5-LOX inhibitor) and conventional non-steroidal anti-inflammatory drugs towards parameters of nitric oxide (NO) system and intensity of oxidative stress in the ...
Increased antitumor efficiency and reduced negative side effects in laboratory mice of 4-thiazolidinone derivatives in complexes with PEG-containing polymeric nanocarrier

Kobylinska, L.I.; Skorohyd, N.R.; Klyuchivska, O.Yu.; Mitina, N.E.; Zaichenko, A.S.; Lesyk, R.B.; Zimenkovsky, B.S.; Stoika, R.S. (Інститут молекулярної біології і генетики НАН УкраїниВiopolymers and Cell, 2018)

Aim. To study an anticancer activity and to measure cytological and enzymatic indicators of general toxicity of 4-thiazolidinone-based compounds (Les-3288, Les-3833) in the NK/Ly lymphoma grafted to BALB/C mice. Methods. ...
Investigation of anticancer and anti-parasitic activity of thiopyrano[2,3-d]thiazoles bearing norbornane moiety

Kryshchyshyn, A.P.; Atamanyuk, D.V.; Kaminskyy, D.V.; Grellier, Ph.; Lesyk, R.B. (Вiopolymers and Cell, 2017)

Aim. To study anticancer activity of a series of new thiopyrano[2,3-d]thiazoles with a norbornane fragment in the molecules. The search for trypanocidal properties of target compounds. Methods. Organic synthesis, analytical ...
Nitric oxide as the main multifunctional regulator of immunocompetent and endothelial cells

Sadlyak, O.V.; Kolishetska, M.A.; Baida, M.L.; Musij-Sementsiv, Kh.G.; Sementsiv, N.G.; Lesyk, R.B. (Вiopolymers and Cell, 2017)

Nitric oxide (NO) plays an important role in metabolism. Consequently, every tissue of our body is affected by changes in concentrations of nitric oxide and its metabolites. Here we analyze phenotypic effects of NO and its ...
Screening of antioxidant and anti-inflammatory activities among thiopyrano[2,3-d]thiazoles

Lozynskyi, A.V.; Kaminskyy, D.V.; Romanchyshyn, Kh.B.; Semenciv, N.G.; Ogurtsov, V.V.; Nektegayev, I.O.; Lesyk, R.B. (Вiopolymers and Cell, 2015)

The aim of present research was the investigation of antioxidant and antiexudative activities of the series of thiopyrano[2,3-d]thiazoles synthesized based on cinnamic acid amides. Methods. Organic synthesis; spectral ...
Screening of spiro-substituted thiopyrano[2,3-d]thiazoles for their cytotoxic action on tumor cells

Zelisko, N.I.; Finiuk, N.S.; Shvets, V.M.; Medvid, Yu.O.; Stoika, R.S.; Lesyk, R.B. (Вiopolymers and Cell, 2017)

Aim. To evaluate the in vitro cytotoxicity of novel spiro-substituted thiopyrano[2,3-d]thiazoles towards tumor cells of different tissue origin. Methods. Organic synthesis; spectral methods; MTT test, statistical analysis. ...
Structure–anticancer activity relationships among 4-azolidinone-3-carboxylic acids derivatives

Kaminskyy, D.V.; Lesyk, R.B. (Вiopolymers and Cell, 2010)

The aim of present research was investigation of anticancer activity of 4-azolidinone-3-carboxylic acids derivatives, and studies of structure–activity relationships (SAR) aspects. Methods. Organic synthesis; spectral ...
Study of molecular mechanisms of proapoptotic action of novel heterocyclic 4-thiazolidone derivatives

Panchuk, R.R.; Chumak, V.V.; Fil', M.R.; Havrylyuk, D.Ya.; Zimenkovsky, B.S.; Lesyk, R.B.; Stoika, R.S. (Вiopolymers and Cell, 2012)

Цель. Исследовать механизмы индукции апоптических сигнальных путей новыми гетероциклическими производными 4-тиазолидонов со структурно отличающимися боковыми группами в злокачественных клетках млекопитающих. Методы. ...
Use of lectin as a vector molecule for delivery of medicinal products to cells and tissues

Antonyuk, V.O.; Klyuchivska, O.Yu.; Antonyuk, R.V.; Lozynskyi, A.V.; Pohranychna, Kh.R.; Lesyk, R.B.; Stoika, R.S. (Вiopolymers and Cell, 2016)

Aim. The conjugation of low-molecular compounds with antitumor activity to lectin and evaluation of the biological activity of the obtained conjugate. Methods. Organic synthesis; obtaining and analyzing Pisum sativum ...
Use of lectins as vector molecules for delivery of drugs to cells and tissues. Report 2.

Antonyuk, V.O.; Skorohyd, N.R.; Lozynskyi, A.V.; Antonyuk, R.V.; Lesyk, R.B.; Stoika, R.S. (Вiopolymers and Cell, 2019)

Aim.To determine cytotoxic effects towards a tumor cells culture of the heterocyclic derivative conjugated with lectins of different carbohydrate specificity. Methods. Conjugation of lectins (Pea seeds (PSA), peanuts (PNA) ...

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Перегляд за автором "Lesyk, R.B."

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