Перегляд за автором "Kornelyuk, A.I."

Результати 1-11 з 11

Autoantibodies against tyrosyl-tRNA synthetase and its separated domains at essential hypertension

Grom, M.Yu.; Yakovenko, L.F.; Granich, V.M.; Dobrohod, A.S.; Torbas, O.O.; Radchenko, A.D.; Sirenko, Yu.M.; Sidorik, L.L.; Kornelyuk, A.I. (Вiopolymers and Cell, 2015)

In addition to the key role in biosynthesis some aminoacyl-tRNA synthetases provide non-canonical functions. Particularly, separated fragments of tyrosyl-tRNA synthetase (TyrRS) involved into angiogenesis and inflammation. ...
Bacterial expression and isotope labeling of AIMP1/p43 codosome protein for structural studies by multidimensional NMR spectroscopy

Vorobyova, N.V.; Lozhko, D.N.; Zhukov, I.Yu.; Kornelyuk, A.I. (Вiopolymers and Cell, 2015)

AIMP1/p43 protein is a structural component of multisynthetase complex (codosome) in eukaryotes, which reveals both tRNA binding and cytokine activities. Aim. Bacterial expression and purification of isotopically-labeled ...
Computational analysis of microarray gene expression profiles of lung cancer

Babichev, S.A.; Kornelyuk, A.I.; Lytvynenko, V.I.; Osypenko, V.V. (Вiopolymers and Cell, 2016)

Aim. The article presents the researches on the optimization of the DNA microarray data processing, which is aimed at improving the quality of object clustering. Methods. Data preprocessing was performed with program R ...
Conformational flexibility of interdomain linker in bovine tyrosyl-tRNA synthetase studied by molecular dynamics simulation

Pydiura, N.A.; Tereshchenko, F.A.; Kornelyuk, A.I. (Біополімери і клітина, 2006)

Here we report a study of molecular dynamics of a YCD2 fragment of mammalian tyrosyl-tRNA synthethase (Asp322-Ser528), which includes the COOH-terminal cytokine-like domain, intermodular flexible linker, and H5-α-helix of ...
Cooperative antitumor effect of endothelial-monocyte activating polypeptide II and flutamide on human prostate cancer xenografts

Reznikov, A.G.; Chaykovskaya, L.V.; Polyakova, L.I.; Kornelyuk, A.I.; Grygorenko, V.N. (Experimental Oncology, 2011)

Recombinant cytokine-like endothelial monocyte-activating polypeptide II (EMAP II) and antiandrogen flutamide target different mechanisms of growth of androgen-dependent prostate cancer (PC). The aim of this study was to ...
Flexible 3D structure of Bos taurus tyrosyl-tRNA synthetase suggests the existence of the hinge mechanism provided by conservative Gly353 at interdomain linker

Pydiura, N.A.; Kornelyuk, A.I. (Вiopolymers and Cell, 2012)

Mammalian tyrosyl-tRNA synthetase is composed of two structural modules: N-terminal catalytic miniTyrRS and non-catalytic cytokine-like C-terminal module connected by a flexible peptide linker. Till now, the 3D structure ...
Homology modeling of structure of NH₂-terminal module of mammalian (Bos taurus) tyrosyl-tRNA synthetase

Odynets, K.A.; Bazylevskyi, O.E.; Kornelyuk, A.I. (Біополімери і клітина, 2002)

Mammalian tyrosyl-tRNA synthetase (TyrRS) is composed of two structural modules: the NH2-terminal catalytic core and cytokine-like COOH-terminal module. In order to elucidate the structural bases for the N-module functions ...
Influence of EMAP II, IFN-α2b and its medicinal preparations on the MGMT protein amount in human cells in vitro

Kotsarenko, K.V.; Lylo, V.V.; Ruban, T.P.; Macewicz, L.L.; Kornelyuk, A.I.; Chernykh, S.I.; Lukash, L.L. (Вiopolymers and Cell, 2014)

Aim. To study the effect of EMAP II, IFN-α2b and its medicinal preparations on the amount of O6-methylguanine-DNA methyltransferase (MGMT) protein in human cells in vitro. Methods. The human cells of 4BL and Hep-2 lines ...
Objective clustering inductive technology of gene expression profiles based on sota clustering algorithm

Babichev, S.A.; Gozhyj, A.; Kornelyuk, A.I.; Lytvynenko, V.I. (Вiopolymers and Cell, 2017)

Aim. Development of an inductive technology of objective clustering of gene expression profiles based on a self-organizing SOTA clustering algorithm. Methods. Inductive methods of complex system analysis were used to ...
Synthesis and characterization of fluorogenic peptide substrate of HIV-1 protease based on fluorescence resonance energy transfer

Kornelyuk, A.I.; Terentiev, A.G.; Fisher, S.; Porter, T. (Биополимеры и клетка, 1995)

Synthesis of fluorogenic peptide substrate of HIV-I protease Dns-SQNYPIVWL which corresponds to the p17/p24 cleavage site for HIV-l protease have been performed. This fluorogenic substrate was based on the fluorescence ...
The mechanisms of substrates interaction with the active site of Mycobacterium tuberculosis tyrosyl-tRNA synthetase studied by molecular dynamics simulations

Mykuliak, V.V.; Kornelyuk, A.I. (Вiopolymers and Cell, 2014)

Aim. To study the mechanisms of substrates interaction with the active site of Mycobacterium tuberculosis tyrosyl-tRNA synthetase (MtTyrRS). Methods. Complexes of MtTyrRS with tyrosine, ATP and tyrosyl adenylate were ...

Результати 1-11 з 11

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