Перегляд за автором "Kolesnik, D.L."

Результати 1-12 з 12

2-deoxy-D-glucose enhances dichloroacetate antitumor action against lewis lung carcinoma

Pyaskovskaya, O.N.; Kolesnik, D.L.; Fedorchuk, A.G.; Prochorova, I.V.; Solyanik, G.I. (Experimental Oncology, 2016)

Aerobic glycolysis that supports high proliferation rate and survival of tumor cells in unfavorable conditions is among fundamental features of tumor metabolism. The search for active modulators of energetic metabolism ...
Aconitine-containing agent enhances antitumor activity of dichloroacetate against Ehrlich carcinoma

Pyaskovskaya, O.N.; Boychuk, I.V.; Fedorchuk, A.G.; Kolesnik, D.L.; Dasyukevich, O.I.; Solyanik, G.I. (Experimental Oncology, 2015)

Significant variability of anticancer efficacy of dichloroacetate (DCA) stimulated an active search for the agents capable to enhance it antitumor action. Therefore, the aim of this work is the study of capability of ...
Analysis of growth kinetics and proliferative heterogeneity of Lewis lung carcinoma cells growing as unfed culture

Pyaskovskaya, O.N.; Kolesnik, D.L.; Kolobov, A.V.; Vovyanko, S.I.; Solyanik, G.I. (Experimental Oncology, 2008)

Аim: To analyze the growth kinetics and proliferative heterogeneity of Lewis lung carcinoma (LLC) cells during their growth in monolayer for 5 days without replacement of culture medium (unfed culture). Methods: Cell biology ...
Changes in VEGF level and tumor growth characteristics during lewis lung carcinoma progression towards CIS-DDP resistance

Pyaskovskaya, O.N.; Dasyukevich, O.I.; Kolesnik, D.L.; Garmanchouk, L.V.; Todor, I.N.; Solyanik, G.I. (Experimental Oncology, 2007)

Aim: To study the relationship between tumor angiogenic potential and its growth and metastasis using Lewis lung carcinoma (LLC) models with different degree of resistance to cis-diamminedichloroplatinum (cis-DDP). Methods: ...
Cytotoxic activity of metformin in vitro does not correlate with its antitumor action in vivo

Pyaskovskaya, O.N.; Kolesnik, D.L.; Fedorchuk, A.G.; Gorbik, G.V.; Solyanik, G.I. (Experimental Oncology, 2017)

It is known that metformin is a hypoglycemic drug used to treat type II diabetes mellitus. Recently active studies of its antitumor activity in relation to different types of malignant cells are conducted. Aim: To determine ...
Dynamics of changes of antioxidant system indexes during the growth of two Lewis lung carcinoma variants

Pyaskovskaya, O.N.; Sorokina, L.V.; Kolesnik, D.L.; Boichuk, I.V.; Melnikov, O.R.; Solyanik, G.I. (Experimental Oncology, 2014)

Aim: To study an intensity of prooxidant processes and activity of antioxidant enzymes in tumor tissue of two Lewis lung carcinoma variants (LLC and LLC/R9) differing by their proliferative, metastatic, and angiogenic ...
Effectiveness of sodium dichloroacetate against glioma с6 depends on administration schedule and dosage

Fedorchuk, A.G.; Pyaskovskaya, O.N.; Gorbik, G.V.; Prokhorova, I.V.; Kolesnik, D.L.; Solyanik, G.I. (Experimental Oncology, 2016)

Background: Anticancer action of sodium dichloroacetate (DCA) could be related to its ability to activate oxidative phosphorylation leading to enhanced generation of reactive oxygen species and induction of apoptosis. On ...
Effect of dichloroacetate on Lewis lung carcinoma growth and metastasis

Kolesnik, D.L.; Pyaskovskaya, O.N.; Boychuk, I.V.; Dasyukevich, O.I.; Melnikov, O.R.; Tarasov, A.S.; Solyanik, G.I. (Experimental Oncology, 2015)

A hallmark of malignancy is excessive tumor glycolysis, even in the presence of oxygen, which causes lactacidosis in the tumor microenvironment and favors tumor cell proliferation and survival. For this reason antimetabolic ...
Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma

Sarnatskaya, V.V.; Nikolaev, V.G.; Yushko, L.A.; Paziuk, L.M.; Karaman, O.M.; Fedosova, N.I.; Kolesnik, D.L.; Dasyukevich, O.I.; Gorbik, G.V.; Maslenny, V.N.; Solyanik, G.I. (Experimental Oncology, 2015)

Aim: To study the correcting effects of microgranulated HSGD enterosorbent on hematological, morphological and biochemical indices of paraneoplastic syndrome in mice with highly angiogenic variant of Lewis lung carcinoma ...
Hypoxia enhances antitumor activity of dichloroacetate

Kolesnik, D.L.; Pyaskovskaya, O.N.; Boichuk, I.V.; Solyanik, G.I. (Experimental Oncology, 2014)

It is known that glycolysis contributes to the survival of tumor cells by providing them with energetic and plastic substrates. Dichloroacetate (DCA) as inhibitor of kinase pyruvate dehydrogenase shifts balance of energy ...
Impact of lactic acidosis on the survival of lewis lung carcinoma cells

Kolesnik, D.L.; Pyaskovskaya, O.N.; Solyanik, G.I. (Experimental Oncology, 2017)

Aim: To investigate the effect of lactic acidosis on the survival of Lewis lung carcinoma cells under glucose-deprived conditions. Materials and Methods: LLC/R9 variant of Lewis lung carcinoma cells was cultured in glucose ...
Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6

Prokhorova, I.V.; Pyaskovskaya, O.N.; Kolesnik, D.L.; Solyanik, G.I. (Experimental Oncology, 2018)

Background: The efficacy of antimetabolic therapy of malignant neoplasms could not be explained solely by the direct mechanisms of action of such energy metabolism inhibitors as sodium dichloroacetate (DCA) and metformin ...

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