Перегляд за автором "Khoruzhenko, A.I."

Результати 1-11 з 11

Adaptor protein TDRD7 is co-localized with ribosomal protein S6 kinases S6K1 and S6K2 in cell lines of different tissue origin

Skorokhod, O.M.; Khoruzhenko, A.I.; Filonenko, V.V. (Вiopolymers and Cell, 2013)

Our previous studies have shown that S6K1 and S6K2 protein kinases form the complexes with newly identified adaptor protein TDRD7, which is involved in regulation of cytoskeleton dynamics, mRNA transport, protein translation, ...
Characteristic of mTOR signaling and its involvement in the regulation of cell movements through remodeling the cytoskeleton architecture

Kosach, V.R.; Cherednyk, O.V.; Khoruzhenko, A.I. (2015)

mTOR kinase is one of the basic links at the crossroad of several signal transduction pathways. Deregulated mTOR kinase signaling accompanies the progress of cancer, diabetes, neurodegenerative disorders and aging. ...
Characterization of novel peptide-specific antibodies against the translation elongation factor eEF1A2 and their application for cancer research

Shalak, V.F.; Vislovukh, A.A.; Novosylna, O.V.; Khoruzhenko, A.I.; Kovalenko, M.I.; Kolesanova, E.F.; Egorova, E.A.; Mishin, A.A.; Krotevych, M.S.; Skoroda, L.V.; Negrutskii, B.S. (Вiopolymers and Cell, 2014)

Aim. We intend to characterize the new peptide-specific antibodies against the isoform 2 of translation elongation factor 1A (eEF1A2) and determine its presence in the postoperative samples of human breast, lung and stomach ...
Exosomes: messengers and mediators of tumor-stromal interactions

Shkarina, K.A.; Cherednyk, O.V.; Voloschenko, I.I.; Trembach, O.M.; Trembach, I.O.; Khoruzhenko, A.I. (Вiopolymers and Cell, 2014)

Intercellular communication is one of the most important factors involved in the maintenance of tissue homeostasis. The alteration of intercellular interaction correlates with a lot of human diseases including cancerogenesis. ...
Generation of HEK-293 stable cell lines with disrupted expression of ribosomal protein S6 kinase (S6K1) isoforms using the CRISPR/Cas9 genome editing system

Zaiets, I.V.; Sivchenko, A.S.; Khoruzhenko, A.I.; Filonenko, V.V. (Вiopolymers and Cell, 2017)

Aim. To generate HEK-293 cells with disrupted expression of S6K1 isoforms: p85, p70 and p60. Methods. CRISPR/Cas9 gene editing, Western blotting, immunofluorescent analysis, RT-PCR analysis, MTT assay, scratch assay. ...
In vitro model for study the interaction between tumor and stromal cells

Shkarina, K.A.; Cherednyk, O.V.; Tykhonkova, I.O.; Khoruzhenko, A.I. (Вiopolymers and Cell, 2013)

Aim. To develop a model to study the interaction between tumor and stromal cells in three-dimensional culture. Methods. Cultivation of HeLa cell lines and human dermal fibroblasts in monolayer and three-dimensional culture, ...
Optimization of cell motility evaluation in scratch assay

Gotsulyak, N.Ya.; Kosach, V.R.; Cherednyk, O.V.; Tykhonkova, I.O.; Khoruzhenko, A.I. (Вiopolymers and Cell, 2014)

A scratch test is one of the most popular methods of classical cell migration assay in a monolayer culture. At the same time, the scratch assay has some disadvantages that can be easily corrected. Aim. Optimization the ...
Optimization of in vitro model for analysis of tumor cell migration dynamics

Kravchenko, A.O.; Kosach, V.R.; Shkarina, K.A.; Zaiets, I.V.; Tykhonkova, I.O.; Khoruzhenko, A.I. (Вiopolymers and Cell, 2018)

Migration ability is an important feature of tumor cells. There are several approaches to analyze the dynamics of cancer cell migration in vitro. One of the most perspective and closer to the in vivo conditions is the model ...
Optimization of tumor cell culture conditions in soft agar for subsequent immunohistochemical analysis

Khoruzhenko, A.I. (Вiopolymers and Cell, 2012)

Мета. Оптимізувати умови культивування злоякісних клітин у напіврідкому агарі для подальшого імуногістохімічного аналізу отриманих тривимірних колоній клітин. Методи. Культивування клітин лінії MCF-7 карциноми молочної ...
Phospho-mTOR (Ser2481) colocalizes with condensed chromosomes during metaphase

Kosach, V.R.; Tykhonkova, I.O.; Cherednyk, O.V.; Filonenko, V.V.; Khoruzhenko, A.I. (Вiopolymers and Cell, 2016)

Aim. To study the subcellular localization of phospho-mTOR (Ser2481) in cultured cells of human cancer cell lines. Methods. Immunofluorescent analysis of phospho-mTOR (Ser2481) subcellular localization in cultured MCF-7 ...
Subcellular localization of S6K1 and S6K2 forms of ribosomal protein S6 kinase in primary monolayer culture of rat thyrocytes

Khoruzhenko, A.I.; Cherednyk, O.V.; Filonenko, V.V. (Біополімери і клітина, 2008)

The main aim of this work was to determine subcellular localization of S6K1 and S6K2 forms of ribosomal protein S6 kinase in the primary monolayer culture of thyrocytes obtained from undamaged follicles. In the thyroid ...

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