Перегляд за автором "Kashuba, V.I."

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Aberrant expression of metallothioneins in clear cell renal cell carcinomas

Rymar, V.I.; Lototskaya, L.V.; Kondratov, O.G.; Stakhovsky, E.O.; Kononenko, O.A.; Kashuba, V.I. (Вiopolymers and Cell, 2015)

Aim. To find candidate tumor suppressor genes among metallothioneins for clear cell renal cell carcinoma. Methods. Analysis of the microarray data, quantitative PCR. Results. We found three genes encoding metallothioneines ...
A novel MECA3 region in human 3p21.3 harboring putative tumor suppressor genes and oncogenes

Braga, E.; Loginov, W.; Khodyrev, D.; Pronina, I.; Kazubskaya, T.; Bogatyrova, O.; Kashuba, V.I.; Senchenko, V.N.; Klein, G.; Lerman, M.I.; Kisselev, L.L.; Zabarovsky, E.R. (Experimental Oncology, 2011)

Aim of this article is to perform the detailed analysis of 3p (especially 3p21 region) to discover novel potential oncogenes and/or tumor suppressors.
A role of expression level of reference and investigated genes in prostate tumors for qPCR analysis

Gerashchenko, G.V.; Stakhovsky, E.O.; Chashchina, L.I.; Gryzodub, O.P.; Kashuba, V.I. (Вiopolymers and Cell, 2018)

Aim. To determine the expression profiles of a set of cancer-associated genes in prostate tumors, using various normalization protocols (with 1, 2 and 4 reference genes) and to optimize a combination of reference genes to ...
Comparative analysis of epigenetic markers in plasma and tissue of patients with colorectal cancer

Kondratov, A.G.; Nekrasov, K.A.; Lototska, L.V.; Panasenko, G.V.; Stoliar, L.A.; Lapska, Y.V.; Kolesnyk, O.O.; Shchepotin, I.B.; Rynditch, A.V.; Kashuba, V.I. (Вiopolymers and Cell, 2014)

Aim. The work is devoted to the development of less invasive tools for the colorectal cancer (CRC) screening. Methods. Q-PCR and methylation-specific PCR techniques were used in the current work. Results. We have shown ...
Detection of prostate specific ETS fusion transcripts in cancer samples

Mevs, L.V.; Gerashchenko, G.V.; Rosenberg, E.E.; Pikul, M.V.; Marynychenko, M.V.; Gryzodub, O.P.; Vozianov, S.O.; Stakhovsky, E.A.; Kashuba, V.I. (Вiopolymers and Cell, 2017)

Aim. To detect ETS fusion transcripts in Ukrainian population and to analyze a possible relationship between the ETS fusion transcripts and clinical characteristics of prostate cancer. Methods. Quantitative PCR (q-PCR) was ...
Development of gene expression panels to determine prostate cancer

Gerashchenko, G.V.; Rynditch, A.V.; Kashuba, V.I. (Доповіді НАН України, 2019)

The aim of this investigation is to prove a modified algorithm for statistical approaches to develop gene expression panels for the detection of prostate tumors. According to Classification and Regression tree models and ...
Expression of cancer-associated genes in prostate tumors

Rosenberg, E.E.; Gerashchenko, G.V.; Hryshchenko, N.V.; Mevs, L.V.; Nekrasov, K.A.; Lytvynenko, R.A.; Vitruk, Y.V.; Gryzodub, O.P.; Stakhovsky, E.A.; Kashuba, V.I. (Experimental Oncology, 2017)

Background: Prostate cancer is one of the most common male cancers in Western countries and takes the third place in morbidity in Ukraine. It is a highly heterogeneous disease. Aim: To analyze relative expression levels ...
Expression of cancer-associated genes in prostate tumors at mRNA and protein levels

Gerashchenko, G.V.; Grygoruk, O.V.; Rosenberg, E.E.; Bondarenko, Yu.M.; Kashuba, E.V.; Kashuba, V.I. (Вiopolymers and Cell, 2019)

Aim. To analyze an expression pattern of the cancer-associated genes in prostate tumors at mRNA and protein levels and find putative association between the expression of these genes and the genes, controlling epithelial ...
Expression of epithelial-mesenchymal transition-related genes in prostate tumours

Gerashchenko, G.V.; Mankovska, O.S.; Dmitriev, A.A.; Mevs, L.V.; Rosenberg, E.E.; Pikul, M.V.; Marynychenko, M.V.; Gryzodub, O.P.; Stakhovsky, E.O.; Kashuba, V.I. (Вiopolymers and Cell, 2017)

Aim. To detect expression of EMT-related genes in prostate tumor samples and analyze a possible correlation between gene expression level and clinical characteristics of prostate cancer in different groups. Methods. ...
Expression of steroid and peptide hormone receptors, metabolic enzymes and EMT-related genes in prostate tumors in relation to the presence of the TMPRSS2/ERG fusion

Gerashchenko, G.V.; Mevs, L.V.; Chashchina, L.I.; Pikul, M.V.; Gryzodub, O.P.; Stakhovsky, E.O.; Kashuba, V.I. (Experimental Oncology, 2018)

Aim: To analyze an expression pattern of the steroid and peptide hormone receptors, metabolic enzymes and EMT-related genes in prostate tumors in relation to the presence of the TMPRSS2/ERG fusion; and to examine a putative ...
Expression patterns of genes that regulate lipid metabolism in prostate tumors

Gerashchenko, G.V.; Kononenko, O.A.; Bondarenko, Yu.M.; Stakhovsky, E.O.; Kashuba, V.I. (Вiopolymers and Cell, 2018)

Aim. To assess relative expression (RE) levels of genes involved in lipid metabolism in prostate tumors. To define clinically significant specific alterations on the basis of the expression pattern. Methods. RE levels were ...
Extreme evolutionary stability of conserved non-protein coding element of baculovirus genome

Makarenko, V.E.; Kikhno, I.M.; Kashuba, V.I. (Вiopolymers and Cell, 2016)

Aim. To estimate a level of evolutionary stability of the baculovirus conserved non protein-coding element (CNE) playing an essential role in baculovirus pathogenesis. Methods. NCBI-BLAST was applied to identify the ...
FOXP3 gene promoter methylation in endometrial cancer cells

Buchynska, L.G.; Iurchenko, N.P.; Verko, N.P.; Nekrasov, K.A.; Kashuba, V.I. (Experimental Oncology, 2015)

Aim: To determine the methylation level of promoter region of the FOXP3 gene promoter depending on the heterogeneity of intracellular localization of its protein product in endometrial cancer (EC) cells and assess its ...
Functional complementation of a conserved non protein-coding element (CNE) of Autographa californica multiple nucleopolyhedrovirus by heterologous CNE originating from Malacosoma neustria nucleopolyhedrovirus

Kikhno, I.M.; Makarenko, V.E.; Kashuba, V.I. (Вiopolymers and Cell, 2016)

Aim. To assess the functional conservation of a baculovirus CNE. Methods. CNE deletion from the baculovirus genome and its replacement with a heterologous CNE was performed by using the bacmid-based technology. ...
Genetic and epigenetic alterations of human chromosome 3, investigated by NotI-microarrays in seven types of epithelial cancers

Gerashchenko, G.V.; Gordiyuk, V.V.; Kashuba, V.I. (Інститут молекулярної біології і генетики НАН УкраїниВiopolymers and Cell, 2018)

Aim. To identify common and specific genetic/epigenetic changes of human chromosome 3, using the data of NotI-microarrays in seven types of epithelial cancers. Methods. We used descriptive statistics for the comparative ...
Genetic and epigenetic changes of GPX1 and GPX3 in human clear-cell renal cell carcinoma

Rudenko, E.E.; Gerashchenko, G.V.; Lapska, Y.V.; Bogatyrova, O.O.; Vozianov, S.O.; Zgonnyk, Y.M.; Kashuba, V.I. (Вiopolymers and Cell, 2013)

Aim. To find putative diagnostic and prognostic markers of cancerogenesis. Methods. Analysis of microarray and SAGE data, quantitative PCR (Q-PCR), bisulfite sequencing, methylation-specific PCR. Results. Bioinformatic ...
Genetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas

Gerashchenko, G.V.; Bogatyrova, O.O.; Rudenko, E.E.; Kondratov, A.G.; Gordiyuk, V.V.; Zgonnyk, Y.M.; Vozianov, O.F.; Pavlova, T.V.; Zabarovsky, E.R.; Rynditch, A.V.; Kashuba, V.I. (Experimental Oncology, 2010)

Renal cell carcinoma (RCC) is the most common malignant tumor of kidney associated with the worst clinical outcome. No molecular markers for RCC diagnostics and prognosis that could be applied in clinics were described ...
Heterozygous deletions are main cause of expression alterations of PPM1M and PRICLE2 genes in human clear cell renal cell carcinomas

Rudenko, E.E.; Lapska, Y.V.; Gerashchenko, G.V.; Stakhovsky, E.O.; Vikarchuk, M.V.; Kashuba, V.I. (2015)

Aim. To discover the mechanisms of the PPM1M and PRICKLE2 genes expression alterations in clear cell renal cell carcinomas. Methods. Study of the copy number was performed, using the quantitative PCR (Q-PCR). Results. ...
Mouse embryonic fibroblasts expressing IFNβ or IL-21 inhibit proliferation of melanoma cells in vitro

Vagyna, I.N.; Zaharuk, O.A.; Strokovska, L.I.; Vagyn, Y.V.; Kashuba, V.I. (Вiopolymers and Cell, 2016)

Aim. To study an influence of mouse embryonic fibroblasts (C57Fb) transduced with baculovirus vectors (BVs), encoding genes for murine Ifn-β or human IL21, on survival and proliferation of the malignant mouse melanoma cells ...
Novel epigenetic markers of early epithelial tumor growth and prognosis

Gordiyuk, V.V.; Kondratov, A.G.; Gerashchenko, G.V.; Kashuba, V.I. (Вiopolymers and Cell, 2013)

The present work is aimed at clarifying genetic and epigenetic alterations that occur during carcinogenesis and designing perspective sets of newly identified biomarkers. The tumors of kidney, cervix, colon, ovary, and ...

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