Перегляд за темою "Reviews"

Сортувати за: Порядок: Результатів:

  • Exosomes: messengers and mediators of tumor-stromal interactions 
    Shkarina, K.A.; Cherednyk, O.V.; Voloschenko, I.I.; Trembach, O.M.; Trembach, I.O.; Khoruzhenko, A.I. (Вiopolymers and Cell, 2014)
    Intercellular communication is one of the most important factors involved in the maintenance of tissue homeostasis. The alteration of intercellular interaction correlates with a lot of human diseases including cancerogenesis. ...
  • Experimental bladder carcinogenesis – rodent models 
    Oliveira, P.A.; Colaco, A.; L.F. De la Cruz, P.; Lopes, C. (Experimental Oncology, 2006)
    Several rodent models of bladder cancer development have been established. The aim of this review article is to provide a critical assessment of different animal models available for the study of bladder carcinogenesis, ...
  • Expression and structural-functional alterations of α-1-acid glycoprotein at the pathological state 
    Stekleneva, N.I.; Shevtsova, A.I.; Brazaluk, O.Z.; Kulinich, A.O. (Вiopolymers and Cell, 2010)
    The review analyzes up-to-date knowledge on structure and biological functions of α-acid glycoprotein. A special attention is given to alterations in fucosylation, sialylation and branching of orosomucoid at the acute, ...
  • Expression of CD40 and CD40L on tumor cells: the role of their interaction and new approach to immunotherapy 
    Bereznaya, N.M.; Chekhun, V.F. (Experimental Oncology, 2007)
    In the review the modern insights on the role of expression of CD40 and CD40L and the role of their interaction on tumor cells growth are analyzed. Information about the structure and biologic properties of these molecules ...
  • Expression of galectin-1 in malignant tumors 
    Demydenko, D.; Berest, I. (Experimental Oncology, 2009)
    Galectin-1 is a 14 kDa lectin expressed ubiquitously in mammalian organism. Since its discovery, the lectin was shown to participate in many cellular processes. Involvement in some of them like induction of apoptosis of ...
  • Extracellular annexins in hemostasis system 
    Zhernossekov, D.D.; Roka-Moiia, Y.M.; Grinenko, T.V. (Вiopolymers and Cell, 2016)
    Annexins are calcium-binding proteins that interact with cellular membranes due to their ability to bind phospholipids. The structural and functional peculiarities of these proteins have been described. Being cytosolic ...
  • Fluorescence tools for studies of membrane protein insertion 
    Kyrychenko, A.V.; Ladokhin, A.S. (Інститут молекулярної біології і генетики НАН УкраїниВiopolymers and Cell, 2018)
    The transition of soluble proteins into lipid membranes and their refolding therein is fundamental to numerous physiological and disease processes. In this review, we present the summary of the application of fluorescence ...
  • Folded genome as a platform for the functional compartmentalization of the eukaryotic cell nucleus 
    Ioudinkova, E.S.; Gavrilov, A.A.; Razin, S.V. (Вiopolymers and Cell, 2014)
    In a number of recent studies a tight interconnection between the spatial organization of the eukaryotic genome and its functioning has been demonstrated. Moreover, it is becoming evident that the folded DNA by itself ...
  • From reverse transcription to human brain tumors 
    Dmitrenko, V.V.; Avdieiev, S.S.; Areshkov, P.O.; Balynska, O.V.; Bukreieva, T.V.; Stepanenko, A.A.; Chausovskii, T.I.; Kavsan, V.M. (Вiopolymers and Cell, 2013)
    Reverse transcriptase from avian myeloblastosis virus (AMV) was the subject of the study, from which the investigations of the Department of biosynthesis of nucleic acids were started. Production of AMV in grams quantities ...
  • Gene targeting in melanoma therapy: exploiting of surface markers and specific promoters 
    Alekseenko, I.V.; Zinovyeva, M.V.; Pleshkan, V.V.; Sverdlov, E.D. (Вiopolymers and Cell, 2012)
    One of the problems of gene therapy of melanoma is effective expression of therapeutic gene in tumor cells and their metastases but not in normal cells. In this review, we will consider a two-step approach to a highly ...
  • Genetic and epigenetic changes in malignant cells of tumors of urogenital organs 
    Gordiyuk, V.V. (Вiopolymers and Cell, 2010)
    More than 90 % of human malignant neoplasms are presented by epithelial tumors. Cancer of urogenital organs is a serious problem because of wide spread of disease and high mortality rates. Tumorogenesis is associated with ...
  • Genetic and epigenetic changes of genes on chromosome 3 in human urogenital tumors 
    Gordiyuk, V.V. (Вiopolymers and Cell, 2011)
    Numerous disorders of genes and alterations of their expression are observed on a short arm of human chromosome 3, particularly in 3p14, 3p21, 3p24 compact regions in epithelial tumors. These aberrations affect the key ...
  • Hodgkin’s lymphoma: the role of cell surface receptors in regulation of tumor cell fate 
    Yurchenko, M.; Sidorenko, S.P. (Experimental Oncology, 2010)
    The hallmark of Hodgkin’s lymphoma (HL) are mononucleated Hodgkin’s cells and multinucleated Reed-Sternberg (HRS) cells, which usually account for only about 1% of cells in the tumor tissue. The majority of HRS cells in ...
  • Hormonal impact on tumor growth and progression 
    Reznikov, A. (Experimental Oncology, 2015)
    In this review, current knowledge of hormones impact on prostate, breast and endometrium cancer growth and transition to hormone therapy resistant phenotype is summarized. A special consideration is given to genetic ...
  • Human genome mutation and rearrangement studies – the way to investigate monogenic and complex disease pathogenesis 
    Livshits, L.A.; Kravchenko, S.A.; Nechyporenko, M.V.; Pampukha, V.M.; Hryshchenko, N.V.; Livshyts, G.B.; Soloviov, O.O.; Tatarskyy, P.F.; Fesai, O.A.; Chernushyn, S.Yu.; Kucherenko, A.M.; Gulkovskyy, R.V. (Вiopolymers and Cell, 2013)
    The summarized results of 25-year studies of department of human genomics of IMBG NASU are presented. The investigations were focused on identification of molecular genetic nature of human genome coding and non-coding ...
  • Hydrogen sulfide and mitochondria 
    Gerush, I.V.; Ferenchuk, Ye.O. (Вiopolymers and Cell, 2019)
    There are different opinions about the role of hydrogen sulfide (H2S) in catalytic and energy processes, but the biochemistry of all possible effects of H2S is not well studied yet. The enzymatic synthesis of H2S is catalyzed ...
  • Inhibition of TGFβ signaling and its implications in anticancer treatments 
    Calone, I.; Souchelnytskyi, S. (Experimental Oncology, 2012)
    The transforming growth factor-β (TGFβ) is a potent regulator of tumorigenesis. In cancer, two distinctive behaviors of TGFβ have been reported as a tumor suppressor at early stage of the disease, and as a tumor promoter ...
  • InsIghts Into the mechanIsm of natural terpenoIds as NF-κB InhIBItors: an overvIew on theIr antIcancer potentIal 
    Jain, H.; Dhingra, N.; Narsinghani, T.; Sharma, R. (Experimental Oncology, 2016)
    The transcription factor, nuclear factor kappa B (NF-kB) is one of the principal inducible protein in mammals known to control the gene expression in many critical physiological responses such as oxidative stress, inflammation ...
  • Insulators in vertebrates: regulatory mechanisms and chromatin structure 
    Ulianov, S.V.; Markova, E.N.; Gavrilov, A.A.; Razin, S.V. (Вiopolymers and Cell, 2012)
    Инсуляторы были открыты как геномные элементы, способные прерывать связь между промотором и энхансером (энхансер-блокирующая активность) и ограничивать распространение гетерохроматина (барьерная активность). У дрозофилы ...
  • Integration of autography, proteasomal degradation, unfolded protein responce and apoptosis 
    Benbrook, D.M.; Long, A. (Experimental Oncology, 2012)
    A single cell has the potential to kill an entire human being. Efforts to cure cancer are limited by survival of individual cancer cells despite immune surveillance and toxic therapies. Understanding the intricate network ...