Перегляд за темою "Reviews"

Сортувати за: Порядок: Результатів:

  • Ribonucleases. possible new approach in cancer therapy 
    Shlyakhovenko, V.O. (Experimental Oncology, 2016)
    In the review, the use of the ribonucleases for cancer therapy is discussed. Using of epigenetic mechanisms of regulation — blocking protein synthesis without affecting the DNA structure — is a promising direction in the ...
  • Role of components of microRNA machinery in carcinogenesis 
    Kian, R.; Moradi, S.; Ghorbian, S. (Experimental Oncology, 2018)
    MicroRNAs (miRNAs) are a broad class of non-coding RNAs nearly 21 nucleotides length, which play crucial functions in posttranscriptional gene regulation. These molecules are associated with many developmental and cellular ...
  • Role of dendrimers in advanced drug delivery and biomedical applications: a review 
    Akbarzadeh, A.; Khalilov, R.; Mostafavi, E.; Annabi, N.; Abasi, E.; Kafshdooz, T.; Herizchi, R.; Kavetskyy, T.; Saghf, S.; Nasibova, A.; Davaran, S. (Experimental Oncology, 2018)
    Aim: Dendrimers dendritic structural design holds vast promises, predominantly for drug delivery, owing to their unique properties. Dendritic architecture is widespread topology found in nature and offers development of ...
  • Role of phytolectin in the life cycle of plants 
    Kovalchuk, N.V.; Melnykova, N.M.; Musatenko, L.I. (Вiopolymers and Cell, 2012)
    В обзоре освещены основные свойства растительных лектинов и обобщены литературные данные по физиологической роли этих белков в жизненном цикле растений. Уделено внимание современным исследованиям фитолектинов и лектиноподобных ...
  • Role of the hybrid Bcr/Abl kinase in the pathogenesis of chronic myeloid leukemia lacking C-Abl and CXCR4 proteins 
    Polishchuk, L.A.; Telegeev, G.D. (Experimental Oncology, 2014)
    Philadelphia chromosome is a result of chromosomal rearrangement that leads to the appearing of the hybrid gene bcr/abl. A hybrid mRNA transcribes from bcr-promoter and many copies of hybrid molecules of Bcr/Abl protein ...
  • Role of vitamin D in modulating gestational diabetes 
    Arora Chander P. (Вiopolymers and Cell, 2011)
    Low maternal levels of major circulating form of vitamin D could be a perplexing factor that leads to expression of gestational diabetes mellitus (GDM). Insufficient or deficient levels of vitamin D may allow diabetic ...
  • Satellite DNA and related diseases 
    Rich, J.; Ogryzko, V.V.; Pirozhkova, I.V. (Вiopolymers and Cell, 2014)
    Satellite DNA, also known as tandemly repeated DNA, consists of clusters of repeated sequences and represents a diverse class of highly repetitive elements. Satellite DNA can be divided into several classes according to ...
  • Several aspects of descriptive epidemiology of hematological malignancies in adult population of Ukraine, Belarus and Russian Federation after Chornobyl accident 
    Guslitser, L.N.; Zavelevich, M.P.; Koval, S.V.; Gluzman, D.F. (Experimental Oncology, 2016)
    Chornobyl impact on the health of adult population in Ukraine, Belarus and Russian Federation was a subject of several studies. However, the studies of the effects of Chornobyl on leukemia in adult populations in post-Soviet ...
  • Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives 
    Grigoryeva, E.S.; Kokova, D.A.; Gratchev, A.N.; Cherdyntsev, E.S.; Buldakov, M.A.; Kzhyshkowska, J.G.; Cherdyntseva, N.V. (Experimental Oncology, 2015)
    In recent years, the new direction such as identification of informative circulating markers reflecting molecular genetic changes in the DNA of tumor cells was actively developed. Smoking-related DNA adducts are very ...
  • Specific features of protein biosynthesis in higher eukaryotes 
    El'skaya, A.V.; Negrutskii, B.S.; Shalak, V.F.; Vislovukh, A.A.; Vlasenko, D.O.; Novosylna, A.V.; Lukash, T.O.; Veremieva, M.V. (Вiopolymers and Cell, 2013)
    Over 40 years of studies in the field of higher eukaryotic translation are summarized in the review. Among the pioneer results obtained we should especially accentuate the following: i) discovery of the adaptation of tRNAs ...
  • Sphingolipids in Apoptosis 
    Tirodkar, T.S.; Voelkel-Johnson, C. (Experimental Oncology, 2012)
    Forty years ago, the term “apoptosis” was introduced to describe a form of programmed cell death. Key players that mediate apoptosis at the molecular level such as caspases, death receptors, Bcl-2 family members have since ...
  • Splice variants in apoptotic pathway 
    Miura, K.; Fujibuchi, W.; Unno, M. (Experimental Oncology, 2012)
    Elimination of superfluous or mutated somatic cells is provided by various mechanisms including apoptosis, and deregulation of apoptotic signaling pathways contributes to oncogenesis. 40 years have passed since the term ...
  • Stem cell – based gene therapy 
    Nazir, Z.; Irshad, S. (Вiopolymers and Cell, 2013)
    Stem cells have huge potential for regenerative medicine. Adult stem cell (HSC)-based therapies have been proved to be safe and efficient for several decades, and adult MSC therapies are showing efficacy in some experiments ...
  • Stem cells and genetic diseases 
    Shahid, S.; Irshad, S. (Вiopolymers and Cell, 2012)
    In this review, we have discussed a role of stem cells in the treatment of genetic diseases including cochlear and retinal regeneration. The most perceptive use of stem cells at the genetic diseases is cellular repair of ...
  • Stress factor – dependent differences in molecular mechanisms of premature cell senescence 
    Petrova, N.V.; Velichko, A.K.; Petrova, N.V.; Razin, S.V.; Kantidze, O.L. (Вiopolymers and Cell, 2015)
    Cell senescence is an established cell stress response in the form of a permanent proliferation arrest accompanied by a complex phenotype. Senescent cells share several crucial features, such as lack of DNA synthesis, ...
  • Structural and functional peculiarities of plasminogen activator inhibitor PAI-1 
    Zhernossekov, D.D.; Zolotareva, E.N.; Kondratuk, A.S. (Вiopolymers and Cell, 2010)
    PAI-1, an important component of the hemostasis system, is a specific inhibitor of both urokinase type and tissue type plasminogen activators. PAI-1 belongs to the serpin family. The interaction between somatomedin-like ...
  • Structural and functional significance of microsatellites 
    Sjakste, T.; Paramonova, N.; Sjakste, N. (Вiopolymers and Cell, 2016)
    Here we review literature data on impact of microsatellite repeats on DNA and chromatin structure and the results of studies on association between the length of microsatellite repeats and predisposition to pathologies. ...
  • Structural plasticity of the nuclear envelope and the endoplasmic reticulum 
    Sheval, E.V.; Musinova, Y.R. (Вiopolymers and Cell, 2014)
    The nuclear envelope is a double membrane structure, continuous with endoplasmic reticulum, and the morphological organization of both these structures is quite conservative. However, nuclear envelope and endoplasmic ...
  • Synthesis and study on biological activity of nitrogen-containing heterocyclic compounds – regulators of enzymes of nucleic acid biosynthesis 
    Alexeeva, I.V.; Shved, A.D. (Вiopolymers and Cell, 2013)
    Results of investigations on the development of new regulators of functional activity of nucleic acid biosynthesis enzymes based on polycyclic nitrogen-containing heterosystems are summarized. Computer design and molecular ...
  • Targeting the anti-apoptotic BCL-2 family members for the treatment of cancer 
    Weyhenmeyer, B.; Murphy, A.C.; Prehn, J.H.M.; Murphy, B.M. (Experimental Oncology, 2012)
    Most cells express a variety of both anti-apoptotic and pro-apoptotic Bcl-2 proteins and the interaction within this family dictates whether a cell survives or dies. The dysregulation of the anti-anti-apoptotic Bcl-2 family ...