Доповіді НАН України, 2008, № 10http://dspace.nbuv.gov.ua:80/xmlui/handle/123456789/54442024-03-29T14:33:31Z2024-03-29T14:33:31ZЗакономірності безкисневого дихання аеробних бактерійДмитренко, Г.М.http://dspace.nbuv.gov.ua:80/xmlui/handle/123456789/61182010-02-17T10:00:50Z2008-01-01T00:00:00ZЗакономірності безкисневого дихання аеробних бактерій
Дмитренко, Г.М.
The ability to perform anaerobic respirations of a collection of strains of the obligate aerobic bacteria of different genera is studied. It is established that the sequence of usages of the elements with variable oxidation degree as the terminal acceptors of electrons by the microorganisms complies with the following electrochemical pattern regularity: the bacteria start to reduce the substance, which has the highest standard electrode potential of reduction.
2008-01-01T00:00:00ZВластивості металотіонеїнів прісноводного двостулкового молюска як біомаркерів стану водного середовищаМіщук, О.В.Столяр, О.Б.Арсан, В.О.http://dspace.nbuv.gov.ua:80/xmlui/handle/123456789/61172010-02-17T10:01:08Z2008-01-01T00:00:00ZВластивості металотіонеїнів прісноводного двостулкового молюска як біомаркерів стану водного середовища
Міщук, О.В.; Столяр, О.Б.; Арсан, В.О.
We have investigated freshwater bivalves Anodonta cygnea from the native population of the Gnizna river (the basin of the Dniester river) in a rural area (N group) and after their dislocation for 30 days in the urban zone of the Gnizna river (U group) and in the recreation zone of the Ternopil Lake (R group). The mussels’ dislocation under new conditions in both cases caused the changes of the chromatography behavior of metallothioneins (MTs) and a decrease of the metal-binding function of MTs alongside with an increase of the zinc content in the mussels’tissues. A decrease of the copper content in the tissues of the mussels of U and R groups was observed. Moreover, the part of copper in MTs of mussels from the Ternopil Lake and the river was increased and decreased, respectively. The variation of the ratio of the zinc and copper contents in MTs of mussels can be a potential biomarker of the changes in water conditions.
2008-01-01T00:00:00ZЕкспресія симпортера натрію/йоду (NIS) в післячорнобильських фолікулярних аденомах щитовидної залозиВоскобойник, Л.Г.Богданова, Т.І.Ромей, К.Елізей, Р.Пинкейра, А.Тронько, М.Д.http://dspace.nbuv.gov.ua:80/xmlui/handle/123456789/61162010-02-17T10:00:49Z2008-01-01T00:00:00ZЕкспресія симпортера натрію/йоду (NIS) в післячорнобильських фолікулярних аденомах щитовидної залози
Воскобойник, Л.Г.; Богданова, Т.І.; Ромей, К.; Елізей, Р.; Пинкейра, А.; Тронько, М.Д.
The expression of NIS protein by immunohistochemistry with the use of a specific monoclonal antibody in 24 post-Chernobyl thyroid follicular adenomas surrounding by normal tissues is studied. It is shown that thyroid follicular adenomas are characterized by heterogeneity as for the expression and localization of NIS. The part of tumors (37.5%) shows the diffuse or local increase of membrane’s NIS expression. Nearly in a half of adenomas (45.8%), the immunohi-stochemical reaction was absent. Localization of NIS in cytoplasm was detected only in oxyphilic cells adenomas.
2008-01-01T00:00:00ZКомбінована дія паклітакселю та селективного інгібітора NFκB дегідроксиметилепоксиквіноміцину на клітини фолікулярного раку щитовидної залозиПушкарьов, В.М.Старенький, Д.В.Гончарук, В.М.Ямашита, С.Саєнко, В.О.Тронько, М.Д.http://dspace.nbuv.gov.ua:80/xmlui/handle/123456789/61152010-02-17T10:01:11Z2008-01-01T00:00:00ZКомбінована дія паклітакселю та селективного інгібітора NFκB дегідроксиметилепоксиквіноміцину на клітини фолікулярного раку щитовидної залози
Пушкарьов, В.М.; Старенький, Д.В.; Гончарук, В.М.; Ямашита, С.; Саєнко, В.О.; Тронько, М.Д.
A novel nuclear factor kappa B (NFκВ) inhibitor, dehydroxymethylepoxyquinomicin, is found to enhance the cytotoxic effect of an anticancer drug paclitaxel in the FRO cell line derived from nondifferentiated thyroid carcinoma of the follicular origin. A strong activation of caspases and PARP cleavage, as well as the decreased levels of small proteins-suppressors of apoptosis, are observed when cells are treated with a combination of both drugs. Of note are the singular paclitaxel treatment induced NF В activation and the NFκВ-dependent phosphorylation of cRaf-1, an upstream kinase of ERK1/2 which is a key member of the mitogen-activated signaling cascade that may comprise an additional NFκВ-induced antiapoptotic pathway. Thus, the combination of paclitaxel and NFκВ inhibitor is a promising pharmacological strategy for further preclinical trials aimed at the development of new therapeutic approaches to the treatment of nondifferentiated and anaplastic thyroid cancer.
2008-01-01T00:00:00Z