Перегляд за темою "Bioorganic Chemistry"

Сортувати за: Порядок: Результатів:

  • Anti-HIV activity of ellagitannins from alder tree fruits 
    Trokhymchuk, T.Yu.; Shalamay, A.S.; Zavelevich, M.P.; Palchykovska, L.G.; Vasylchenko, O.V.; Rybalko, S.L.; Starosyla, D.B.; Diadiun, S.T. (Вiopolymers and Cell, 2018)
    Aim. To assess the inhibitory activity of ellagitannin complex of the purified extract from the fruits of white alder and black alder in non-eukaryotic polymerase systems and to analyze the effects of these substances on ...
  • Antineoplastic activity of novel thiazole derivatives 
    Finiuk, N.S.; Hreniuh, V.P.; Ostapiuk, Yu.V.; Matiychuk, V.S.; Frolov, D.A.; Obushak, M.D.; Stoika, R.S.; Babsky, A.M. (Вiopolymers and Cell, 2017)
    The development of novel efficient substances for anticancer chemotherapy is an important problem of medicinal chemistry. Aim. To evaluate the level of cytotoxic action of novel thiazole derivatives towards tumor cell lines ...
  • Computer-aided design of novel HIV-1 entry inhibitors blocking the virus envelope gp120 V3 loop 
    Andrianov, A.M.; Anishchenko, I.V.; Kisel, M.A.; Kornoushenko, Yu.V.; Nikolayevich, V.A.; Eremin, V.F.; Kucherov, I.I.; Tuzikov, A.V. (Вiopolymers and Cell, 2012)
    Aim. The object of this study was to implement computer-aided design of the water-soluble analog of glycolipid β -galactosylceramide (β-GalCer), which presents a potential HIV-1 entry inhibitor, by the analysis of ...
  • Design of 4-(4-dialkylaminostyryl) -pyridinium dyes for fluorescent detection of amyloid fibrils 
    Inshyn, D.I.; Chernii, S.V.; Kovalska, V.B.; Yarmoluk, S.M. (Вiopolymers and Cell, 2016)
    The pathological proteins aggregation into the fibrillar structures is common to a large group of amyloid-related disorders, such as neurodegenerative diseases. Accordingly, there is a need for development of analytical ...
  • DNA-binding studies of a series of novel water-soluble derivatives of 1,4-dihydropyridine 
    Leonova, E.; Rostoka, E.; Baumane, L.; Borisovs, V.; Smelovs, E.; Bisenieks, I.; Brūvere, I.; Bisenieks, E.; Duburs, G.; Sjakste, N. (Вiopolymers and Cell, 2018)
    Aim. to determine DNA interaction modes for a series of 1,4-dihydropyridines with different biological activities synthesized in the Latvian Institute of Or-ganic Synthesis. Methods. Affinity of the compounds to DNA was ...
  • Dynamics of dye release from nanocarriers of different types in model cell membranes and living cells 
    Tkacheva, T.N.; Yefimova, S.L.; Klochkov, V.K.; Sorokin, A.V.; Malyukin, Yu.V. (Вiopolymers and Cell, 2014)
    Aim. To study the dynamics of lipophilic content release from nanocarriers of different types, organic molecular ensembles and inorganic nanoparticles (NPs) in vitro experiments. Methods. Two-channel ratiometric fluorescence ...
  • Effect of 24-epibrassinolide on lipoxygenase activity in maize seedlings under cold stress 
    Kopich, V.N.; Kretynin, S.V.; Kharchenko, O.V.; Litvinovskaya, R.P.; Chashina, N.M.; Khripach, V.A. (Вiopolymers and Cell, 2010)
    Aim. To investigate 24-epibrassinolide influence on the maize seedlings 9- and 13-lipoxygenases activity (9- and 13-LOX) under normal conditions (25 oC) and cold stress (5 oC). Methods. LOX activity was measured after ...
  • Effect of inorganic nanoparticles and organic complexes on their basis on free-radical processes in some model systems 
    Averchenko, K.A.; Kavok, N.S.; Klochkov, V.K.; Sedyh, O.O.; Yefimova, S.L.; Malyukin, Yu.V. (Вiopolymers and Cell, 2015)
    Aim. Evaluation of free–radical activity of rare–earth based nanoparticles (NPs) (orthovanadates and CeO2) with different geometrical parameters, and organic complexes formed on their base with methylene blue (MB) photodynamic ...
  • Effects of oxyethylated glycerol cryoprotectants on phase transitions of DPPC model membranes 
    Kasian, N.A.; Krasnikova, A.O.; Vashchenko, O.V.; Lisetski, L.N.; Zinchenko, A.V.; Kompaniets, A.M.; Ratushna, M.V. (Вiopolymers and Cell, 2015)
    Aim. To determine the effect of the oxyethylated glycerol cryoprotectants (OEGn) with polymerization degrees n = 5, 25, 30 on the phase states and phase transitions of dipalmitoylphosphatidylcholine (DPPC)-based model ...
  • Fluorine-containing polyamphiphiles of block structure constructed of synthetic and biopolymer blocks 
    Paiuk, O.L.; Mitina, N.Ye.; Myagkota, O.S.; Volianiuk, K.A.; Musat, N.; Stryganyuk, G.Z.; Reshetnyak, O.V.; Kinash, N.I.; Hevus, O.I.; Shermolovich, Yu.G.; Zaichenko, A.S. (Вiopolymers and Cell, 2018)
    Aim. Purposeful preparation of polymeric surfactants combining hydrophobic fluorine-containing and hydrophilic synthetic and natural blocks via radical and non-radical reactions using peroxide, epoxide and/or amino- terminal ...
  • Genotoxicity of a carcinogenic metabolite of benzo[a]pyrene for cells of neuronal differentiation lineage 
    Endutkin, A.V.; Sidorenko, V.S.; Zharkov, D.O. (Вiopolymers and Cell, 2012)
    Цель. Бензо[a]пирен-7,8-дигидродиол-9,10-эпоксид (BPDE) – основной метаболит канцерогенного полициклического ароматического углеводорода бензо[a]пирена. Влияние BPDE на предшественники нервных клеток практически не ...
  • Glycyrrhetinic acid and its derivatives as inhibitors of poly(ADP-ribose)polymerases 1 and 2, apurinic/apyrimidinic endonuclease 1 and DNA polymerase β 
    Zakharenko, A.L.; Salomatina, O.V.; Sukhanova, M.V.; Kutuzov, M.M.; Ilina, E.S.; Khodyreva, S.N.; Schreiber, V.; Salakhutdinov, N.F.; Lavrik, O.I. (Вiopolymers and Cell, 2012)
    Для усиления эффективности влияния монофункциональных алкилирующих противоопухолевых препаратов важно снизить активность системы эксцизионной репарации оснований (ЭРО), исправляющей значительную часть повреждений ДНК, ...
  • Hit identification of CK2 inhibitors by virtual screening 
    Protopopov, M.V.; Starosyla, S.A.; Borovykov, O.V.; Sapelkin, V.N.; Bilokin, Y.V.; Bdzhola, V.G.; Yarmoluk, S.M. (Вiopolymers and Cell, 2017)
    Aim. To search for new CK2 inhibitors by virtual screening. Methods. Virtual screening of a small organic compounds library was performed by molecular docking using the Autodock 4.2.6 package and pharmacophore screening ...
  • Hit identification of FGFR1 inhibitors using receptor-based virtual screening 
    Tarnavskiy, S.S.; Protopopov, M.V.; Borovykov, O.V.; Pryhodko, A.O.; Bdzhola, V.G.; Yarmoluk, S.M. (Вiopolymers and Cell, 2019)
    Aim. To identify novel FGFR1 inhibitors using the virtual screening approach. Methods. Virtual screening of a small organic compounds library was performed by molecular docking using the Autodock 4.2.6 program package. The ...
  • Identification of 4‐methoxythieno[2,3‐d]pyrimidines as FGFR1 Inhibitors 
    Kotey, I.M.; Protopopov, M.V.; Starosyla, S.A.; Balanda, A.O.; Pletnova, L.V.; Prykhod'ko, A.O.; Bdzhola, V.G.; Yarmoluk, S.M. (Вiopolymers and Cell, 2019)
    Aim. To identify novel FGFR1 inhibitors using virtual screening approach. Methods. We used methods of organic synthesis, molecular docking via the Autodock 4.2.6 program package and in vitro biochemical tests with γ-32P. ...
  • Increased antitumor efficiency and reduced negative side effects in laboratory mice of 4-thiazolidinone derivatives in complexes with PEG-containing polymeric nanocarrier 
    Kobylinska, L.I.; Skorohyd, N.R.; Klyuchivska, O.Yu.; Mitina, N.E.; Zaichenko, A.S.; Lesyk, R.B.; Zimenkovsky, B.S.; Stoika, R.S. (Інститут молекулярної біології і генетики НАН УкраїниВiopolymers and Cell, 2018)
    Aim. To study an anticancer activity and to measure cytological and enzymatic indicators of general toxicity of 4-thiazolidinone-based compounds (Les-3288, Les-3833) in the NK/Ly lymphoma grafted to BALB/C mice. Methods. ...
  • Inhibition of in vitro transcription by 2-arylidene derivatives of thiazolo[3,2-α]benzimidazol-3(2H)-one 
    Palchykovska, L.G.; Alexeeva, I.V.; Negrutska, V.V.; Kostyuk, Yu.K.; Indychenko, T.M.; Kostenko, O.M.; Kryvorotenko, D.V.; Shved, A.D.; Dubey, I.Ya. (Вiopolymers and Cell, 2010)
    Aim. To evaluate a series of 2-substituted thiazolo[3,2-α]benzimidazolones as potential transcription inhibitors. Methods. Compounds were tested in a model transcription system based on T7 RNA polymerase. Results. The ...
  • Interaction of cationic porphyrin-imidazophenazine conjugates with DNA quadruplex: FID assay and quantum-chemical modeling 
    Didan, Yu.V.; Ilchenko, M.M.; Negrutska, V.V.; Dubey, L.V.; Ryazanova, O.A.; Dubey, I.Ya. (Вiopolymers and Cell, 2018)
    Aim. To study the efficiency of tricationic porphyrin–imidazo[4,5-b]phenazine conjugate and its Zn(II) and Mn(III) complexes as G-quadruplex (G4) DNA ligands. Methods. FID (Fluorescent Intercalator Displacement) assay was ...
  • Investigation of anticancer and anti-parasitic activity of thiopyrano[2,3-d]thiazoles bearing norbornane moiety 
    Kryshchyshyn, A.P.; Atamanyuk, D.V.; Kaminskyy, D.V.; Grellier, Ph.; Lesyk, R.B. (Вiopolymers and Cell, 2017)
    Aim. To study anticancer activity of a series of new thiopyrano[2,3-d]thiazoles with a norbornane fragment in the molecules. The search for trypanocidal properties of target compounds. Methods. Organic synthesis, analytical ...
  • Lepidine Orange derivative as a new dye for sensitive fluorescent detection of DNA 
    Didan, Yu.V.; Kryvorotenko, D.V.; Negrutska, V.V.; Dubey, I.Ya. (Вiopolymers and Cell, 2013)
    Aim. To study new cyanine dye LO-7 as a reagent for dsDNA visualization in electrophoretic gels. Methods. Gel electrophoresis, restriction, fluorescence detection, mobility shift assay. Results. LO-7 binds to DNA to form ...