Перегляд за темою "Reviews"

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  • 2'-5'-Oligoadenylates as a «tool» of innate immunity 
    Tkachuk, Z.Yu. (Вiopolymers and Cell, 2013)
    It is a matter of common knowledge, that «core» 2'-5'-oligoadenylates and their analogues posses broader biological activity than it can be predicted within the traditional «interferon» hypothesis. They exhibit immunomodulatory ...
  • 2D- and 3D-cell culture 
    Khoruzhenko, A. I. (Вiopolymers and Cell, 2011)
    The cultivation of mammalian cells in three-dimensional conditions acquires a priority in a variety of biomedical applications. In the areas of toxicology and anticancer drug development it concerns a significant difference ...
  • 40 years within two epochs of two millennia 
    Kordium, V.A. (Вiopolymers and Cell, 2013)
    The article-generalization deals with the main directions being developed in the Department of Cell Regulatory Mechanisms during past 40 years from the moment of the Institute of Molecular Biology and Genetics of Academy ...
  • Aberrant DNA glycosylase-initiated repair pathway of free radicals in-duced DNA damage: implications for age-related diseases and natural aging 
    Matkarimov, B.T.; Saparbaev, M.K. (Вiopolymers and Cell, 2017)
    Aerobic cellular respiration generates reactive oxygen species (ROS), which can damage macro-molecules including lipids, proteins and DNA. It was proposed that aging is a consequence of accumulation of naturally occurring ...
  • Accelerated cellular senescence in solid tumor therapy 
    Wu, P.C.; Wang, Q.; Grobman, L.; Chu, E.; Wu, D.Y. (Experimental Oncology, 2012)
    Accelerated cellular senescence (ACS) is an emerging concept that implicates sustained, telomere-independent cell cycle arrest of neoplastic cells in response to chemotherapeutic agents, ionizing radiation, oxidative stress, ...
  • Allelic polymorphism of glucocorticoid receptor NR3C1 (GR): from molecular biology to clinical implications 
    Orlovsky, M.A. (Вiopolymers and Cell, 2012)
    Polymorphism of stress-related genes is a key factor determining difference in the stress reactivity and resistance among humans. Glucocorticoid receptors are important actors of stress responses. This review is focused ...
  • Amplification and co-regulators of androgen receptor gene in prostate cancer 
    Golias, Ch.; Iliadis, I.; Peschos, D.; Charalabopoulos, K. (Experimental Oncology, 2009)
    Prostate cancer isthe second most common malignancy among males after lung cancer. The growth of prostate cancer cells depends on the presence of androgens, a group ofsteroid hormones that include testosterone and its ...
  • Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome 
    Grybach, S.M.; Polishchuk, L.Z.; Chekhun, V.F. (Experimental Oncology, 2018)
    Aim: To analyze the survival of patients with breast cancer (BC) depending on age, molecular subtype of the tumor and the presence of metabolic syndrome. Patients and Methods: We have analyzed the results of examination ...
  • Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome 
    Grybach, S.M.; Polishchuk, L.Z.; Chekhun, V.F. (Experimental Oncology, 2018)
    Aim: To analyze the survival of patients with breast cancer (BC) depending on age, molecular subtype of the tumor and the presence of metabolic syndrome. Patients and Methods: We have analyzed the results of examination ...
  • An overview on "cellular cannibalism” with special reference to oral squamous cell carcinoma 
    Jain, M. (Experimental Oncology, 2015)
    Cellular cannibalism has been defined as a large cell engulfing a slightly smaller one within its cytoplasm. It has been described in various cancers like bladder cancer, breast cancer, lung cancer, gastric cancer, oral ...
  • Anticancer substances of mushroom origin 
    Ivanova, T.S.; Krupodorova, T.A.; Barshteyn, V.Y.; Artamonova, A.B.; Shlyakhovenko, V.A. (Experimental Oncology, 2014)
    The present status of investigations about the anticancer activity which is inherent to medicinal mushrooms, as well as their biomedical potential and future prospects are discussed. Mushroom products and extracts possess ...
  • Anticancer therapy and apoptosis imaging 
    Yalcin, T.J.; Haimovitz-Friedman, A.; Verheij, M. (Experimental Oncology, 2012)
    Early response prediction is considered an essential tool to obtain a more customized anticancer treatment because it allows for the identification of patients who will benefit most from a particular therapy and prevents ...
  • Apoptosis in radiation therapy: a double-edged sword 
    Balcer-Kubiczek, E.K. (Experimental Oncology, 2012)
    Radiation therapy achieves its therapeutic effects by inducing apoptosis and non-apoptotic cell death. The aim of this focused review is to highlight the aspects of the cell death pathways most relevant to conventional ...
  • A potential role of hydrogen sulfide (H₂S) in the regulation of the Ras-ERK signaling-dependent transcription of DNA methyltransferases 
    Nikitina, T.A. (Вiopolymers and Cell, 2016)
    Ras-ERK cell signaling regulates transcription of DNA methyltransferases (DNMTs). A role of H₂S in regulation of the Ras-ERK signaling activity and DNMTs expression has also been shown. Here we propose a hypothesis that ...
  • A review on microcephaly genes 
    Shahid, S.; Irshad, S. (Вiopolymers and Cell, 2012)
    В обзоре обобщены данные последних лет по изучению генов микроцефалии. Обсуждаются результаты молекулярно-генетического исследования этих генов, сделана оценка семи определенных локусов (MCPH1–MCPH7), описаны соответствующие ...
  • At a crossroads of cancer risk and aging: the role of telomeres 
    Gerashchenko, B.I. (Experimental Oncology, 2010)
    The risk of overall cancer inevitably increases with advancing age. The cancer incidence rate is not constant within the human life span (it exponentially increases with advancing age). Aging itself is a complex biological ...
  • Baculovirus vectors in experimental geneand vaccine therapy 
    Solomko, A.P.; Zaharuk, O.A.; Chaschina, L.I.; Strokovskaya, L.I. (Вiopolymers and Cell, 2011)
    The article provides a brief overview of the literature on target design, exploration properties and effectiveness of the application of recombinant baculoviruses in model systems in vivo. The results of experiments with ...
  • Biosensors. A quarter of a century of R&D experience 
    Soldatkin, A.P.; Dzyadevych, S.V.; Korpan, Y.I.; Sergeyeva, T.A.; Arkhypova, V.N.; Biloivan, O.A.; Soldatkin, O.O.; Shkotova, L.V.; Zinchenko, O.A.; Peshkova, V.M.; Saiapina, O.Y.; Marchenko, S.V.; El'skaya, A.V. (Вiopolymers and Cell, 2013)
    The paper is a review of the researches of Biomolecular Electronics Laboratory concerning the development of biosensors based on electrochemical transducers (amperometric and conductometric electrodes, potentiometric ...
  • Cancer–stroma interactions as a target for cancer treatment. 
    Alekseenko, I.V.; Pleshkan, V.V.; Sverdlov, E.D. (Інститут молекулярної біології і генетики НАН УкраїниВiopolymers and Cell, 2018)
    During tumor evolution, cancer cells use the tumor-stroma crosstalk to reorganize the microenvironment for maximum robustness of tumor. The success of immune checkpoint therapy generates a new cancer therapy paradigm: an ...
  • Carbon adsorbents in oncology: achievements and perspectives 
    Nikolaev, V.G.; Sakhno, L.A.; Snezhkova, E.A.; Sarnatskaya, V.V.; Yushko, L.A. (Experimental Oncology, 2011)
    The results of own investigations and literature data are summarized to determine the place of the main methods of adsorption therapy in complex treatment of the patients with malignant tumors. New possibilities for the ...