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17-AAG mediates targeting of HSP90 limits tert activity in peritoneal sarcoma related malignant ascites by downregulating cyclin D1 during cell cycle entry

Chaklader, M.; Das, P.; Pereira, J.A.; Law, A.; Chattopadhyay, S.; Chatterjee, R.; Mondal, A.; Law, S. (Experimental Oncology, 2012)

Aim: Peritoneal or retro-peritoneal sarcomatosis related malignant ascites formation is a rare but serious consequence of the locoregional metastatic event. The present work aimed to study the effect of the Hsp90 inhibitor ...
2-deoxy-D-glucose enhances dichloroacetate antitumor action against lewis lung carcinoma

Pyaskovskaya, O.N.; Kolesnik, D.L.; Fedorchuk, A.G.; Prochorova, I.V.; Solyanik, G.I. (Experimental Oncology, 2016)

Aerobic glycolysis that supports high proliferation rate and survival of tumor cells in unfavorable conditions is among fundamental features of tumor metabolism. The search for active modulators of energetic metabolism ...
Aberrant expression of selenium-containing glutathione peroxidases in clear cell renal cell carcinomas

Rudenko, E.; Kondratov, O.; Gerashchenko, G.; Lapska, Y.; Kravchenko, S.; Koliada, O.; Vozianov, S.; Zgonnyk, Y.; Kashuba, V. (Experimental Oncology, 2015)

Aim: To find putative diagnostic markers for clear cell renal cell carcinomas (ccRCC). Material and methods: Quantitative polymerase chain reaction (Q-PCR), bisulfite treatment, methylation-specific PCR, analysis on ...
Aberrant promoter hypermethylation of selected apoptotic genes in childhood acute lymphoblastic leukemia among north indian population

Nikbakht, M.; Jha, A.K.; Malekzadeh, K.; Askari, M.; Mohammadi, S.; Marwaha, R.K.; Kaul, D.; Kaur, J. (Experimental Oncology, 2017)

Promoter hypermethylation mediates gene silencing in many neoplasms. Acute leukemia has been reported to harbor multiple genes aberrantly silenced by hypermethylation. Aim: In present study, we investigated the prevalence ...
Abnormalities of apoptosis of the thyroid gland cells from extratumoral microfollicular tissue

Myshunina, T.M.; Kalinichenko, O.V.; Tronko, N.D. (Experimental Oncology, 2012)

Aim: The aim of this study was to evaluate the frequency of existence of thyroid extratumoral normo- and microfollicular tissue in patients with thyroid carcinoma and peculiarities of apoptosis in mentioned tissue. Materials ...
Aconitine-containing agent enhances antitumor activity of dichloroacetate against Ehrlich carcinoma

Pyaskovskaya, O.N.; Boychuk, I.V.; Fedorchuk, A.G.; Kolesnik, D.L.; Dasyukevich, O.I.; Solyanik, G.I. (Experimental Oncology, 2015)

Significant variability of anticancer efficacy of dichloroacetate (DCA) stimulated an active search for the agents capable to enhance it antitumor action. Therefore, the aim of this work is the study of capability of ...
Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities

Borzenko, B.G.; Bakurova, E.M.; Popovich, Yu.A.; Sidyuk, E.A.; Popovich, A.Y. (Experimental Oncology, 2013)

A comparative study of enzyme activity features of thymidilate “salvage pathway” synthesis in blood serum and tissues of different age patients with gastric cancer (T3–4N0-xM0) was carried out. Aim: To evaluate the diagnostic ...
Administration of vitamin D3 improves antimetastatic efficacy of cancer vaccine therapy of Lewis lung carcinoma

Zhuravel, E.; Efanova, O.; Shestakova, T.; Glushko, N.; Mezhuev, O.; Soldatkina, M.; Pogrebnoy, P.V. (Experimental Oncology, 2010)

Aim: To analyze antitumor efficacy of experimental cancer vaccine therapy combined with introduction of vitamin D3 (VD3) for treatment of Lewis lung carcinoma (3LL). Materials and Methods: Cancer vaccines composed from ...
Adsorption-rheological properties of blood serum in lung cancer patients

Dumanskiy, Y.V.; Stoliarova, O.Y.; Syniachenko, O.V.; Giulmamedova, M.F.; Potapov, Y.A. (Experimental Oncology, 2017)

The aim and objectives of the study were to investigate the state of adsorption-rheological properties of blood (ARPB) in patients with different clinical course of lung cancer (LC), the detection of violations of ...
Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression

Cherdyntseva, N.V.; Gervas, P.A.; Litvyakov, N.V.; Stakcheeva, M.N.; Ponomaryeva, A.A.; Dobrodeev, A.Yu.; Denisov, E.V.; Belyavskaya, V.A.; Choinzonov, E.L. (Experimental Oncology, 2010)

Aim: To examine the influence of combined genotypes of TP53 (exon 4, intron 3, intron 6) and XRCC1 (codon 10) on lung cancer age of onset. Methods: TP53 polymorphisms in codon 72 of exon 4 (Arg72Pro), in intron 3 (16 bp ...
Alteration in lipid composition of plasma membranes of sensitive and resistant Guerin carcinoma cells due to the action of free and liposomal form of cisplatin

Naleskina, L.A.; Todor, I.N.; Nosko, M.M.; Lukianova, N.Yu.; Pivnyuk, V.M.; Chekhun, V.F. (Experimental Oncology, 2013)

Aim: To study in vivo changes of lipid composition of plasma membranes of sensitive and resistant to cisplatin Guerin carcinoma cells under influence of free and liposomal cisplatin forms. Materials and Methods: The isolation ...
Alterations of antitumor and metabolic responses in L5178Y-R lymphoma-bearing mice after only 30-minute daily chronic stress exposure

Caballero-Hernandez, D.; Najera-Valderrabano, D.; Valadez-Lira, A.; Franco-Molina, M.; Gomez-Flores, R.; Tamez-Guerra, P.; Tamez-Guerra, R.; Rodríguez-Padilla, C. (Experimental Oncology, 2017)

Aim: In stress research, reducing times of stress induction may contribute to improving the well-being of experimental animals, especially in cancer models, already under physiological distress. To support this idea, we ...
Amifostine can differentially modulate DNA double-strand breaks and apoptosis induced by idarubicin in normal and cancer cells

Wozniak, K.; Gloc, E.; Morawiec, Z.; Blasiak, J. (Experimental Oncology, 2008)

We have previously shown that amifostine differentially modulated the DNA-damaging action of idarubicin in normal and cancer cells and that the presence of p53 protein and oncogenic tyrosine kinases might play a role in ...
Analysis of growth kinetics and proliferative heterogeneity of Lewis lung carcinoma cells growing as unfed culture

Pyaskovskaya, O.N.; Kolesnik, D.L.; Kolobov, A.V.; Vovyanko, S.I.; Solyanik, G.I. (Experimental Oncology, 2008)

Аim: To analyze the growth kinetics and proliferative heterogeneity of Lewis lung carcinoma (LLC) cells during their growth in monolayer for 5 days without replacement of culture medium (unfed culture). Methods: Cell biology ...
Analysis of P53, P16INK4A, PRB and cyclin D1 expression and human papillomavirus in primary ovarian serous carcinoma

Bilyk, O.O.; Pande, N.T.; Buchynska, L.G. (Experimental Oncology, 2011)

Aim: To evaluate the prognostic relevance of key cell cycle regulatory proteins p53, p16INK4a, pRb and Cyclin D1 expression, the presence of high risk HPVs and their association with clinicopathological parameters and the ...
Analysis of relative telomere length and apoptosis in humans exposed to ionising radiation

Ilyenko, I.; Lyaskivska, O.; Bazyka, D. (Experimental Oncology, 2011)

Background: Ionizing radiation could modify lymphocyte function via oxidative damage, DNA breaks, and resulting changes of proliferation, apoptosis and cellular senescence, where telomeres may play a critical role. Aim: ...
Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients

Abramenko, I.V.; Bilous, N.I.; Chumak, A.A.; Dyagil, I.S.; Martina, Z.V. (Experimental Oncology, 2018)

Deregulation of NOTCH1-signalling pathway is common in chronic lymphocytic leukemia (CLL). The most of studies are focused on detection of the hotspot c.7541_7542delCT NOTCH1 mutations in exon 34, while studies of mutations ...
A novel MECA3 region in human 3p21.3 harboring putative tumor suppressor genes and oncogenes

Braga, E.; Loginov, W.; Khodyrev, D.; Pronina, I.; Kazubskaya, T.; Bogatyrova, O.; Kashuba, V.I.; Senchenko, V.N.; Klein, G.; Lerman, M.I.; Kisselev, L.L.; Zabarovsky, E.R. (Experimental Oncology, 2011)

Aim of this article is to perform the detailed analysis of 3p (especially 3p21 region) to discover novel potential oncogenes and/or tumor suppressors.
Antiangiogenic properties of a nutrient mixture in a model of hemangioma

Roomi, M.W.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. (Experimental Oncology, 2009)

The pathogenesis of hemangiomas is still largely unknown and the current therapy, such as systemic corticosteroid, vincristine, and interferon-alpha, is toxic and remains unsatisfactory. A nutrient mixture (NM) containing ...
Antibodies against benzo

Ustinov, V.A.; Matveeva, V.A.; Kostyanko, M.A.; Glushkov, A.N. (Experimental Oncology, 2013)

Aim: To evaluate the production of antibodies against benzo[a]pyrene (BF) (Ab1) and corresponding antiidiotypic antibodies (AM) in mice after immunization with BP-protein conjugate and in lung cancer patients. Materials ...

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