Перегляд за автором "Chekhun, V.F."

Результати 21-40 з 56

Expression of drug resistance proteins in triple-receptor-negative tumors as the basis of individualized therapy of the breast cancer patients

Chekhun, V.F.; Zhylchuk, V.E.; Lukyanova, N.Yu.; Vorontsova, A.L.; Kudryavets, Yu.I. (Experimental Oncology, 2009)

Aim: To evaluate the efficacy ofthe application of various chemotherapy schemes based on the immunohistochemical study of expression patterns of proteins associated with the drug resistance P-glycoprotein (P-gp), ...
Foreword to the special issue on apoptosis

Chekhun, V.F. (Experimental Oncology, 2012)
Fractal dimension of the breast cancer cells resistant and sensitive to doxorubicin activity

Medviediev, O.; Gorobets, O.Yu.; Chekhun, V.F.; Gorobets, S.V.; Demyanenko, I.V.; Butenko, K.O. (Functional Materials, 2016)

The main purpose of this research is examining and comparing of the fractal dimension (FD) and quantity of biogenic magnetic nanoparticles (BMN) of the resistant and sensitive MCF-line breast cancer cells to doxorubicin ...
Gold nanoparticles synthesis and biological activity estimation in vitro and in vivo

Rieznichenko, L.S.; Dybkova, S.M.; Gruzina, T.G.; Ulberg, Z.R.; Todor, I.N.; Lukyanova, N.Yu.; Shpyleva, S.I.; Chekhun, V.F. (Experimental Oncology, 2012)

The aim of the work was the synthesis of gold nanoparticles (GNP) of different sizes and the estimation of their biological activity in vitro and in vivo. Materials and Methods: Water dispersions of gold nanoparticles of ...
Hepcidin as a possible marker in determination of malignancy degree and sensitivity of breast cancer cells to cytostatic drugs

Yalovenko, T.M.; Todor, I.M.; Lukianova, N.Y.; Chekhun, V.F. (Experimental Oncology, 2016)

Aim: To investigate the role of hepcidin (Hepc) in the formation of cells malignant phenotype in vitro and its expression in the dyna mics of growth of Walker-256 carcinosarcoma with different sensitivity to doxorubicin ...
Increase of antitumor activity of cisplatin using agonist of gonadotropin-realising hormone and inhibitor of aromatase on the model of ascites ovarian tumor

Tkalia, I.G.; Vorobyova, L.I.; Grabovoy, A.N.; Svintsitsky, V.S.; Tarasova, T.О.; Lukyanova, N.Y.; Todor, I.N.; Chekhun, V.F. (Experimental Oncology, 2014)

Aim : To study antitumor activity of triptorelin — agonist of gonadotropin-releasing hormone and exemestane — inhibitor of aromatase in monotherapy and in combination with cisplatin on the model of receptor-positive for ...
Influence of exogenous lactoferrin on the oxidant/ antioxidant balance and molecular profile of hormone receptor-positive and -negative human breast cancer cells in vitro

Zalutski, I.V.; Lukianova, N.Y.; Storchai, D.M.; Burlaka, A.P.; Shvets, Y.V.; Borikun, T.V.; Todor, I.M.; Lukashevich, V.S.; Rudnichenko, Y.A.; Chekhun, V.F. (Experimental Oncology, 2017)

Aim: To investigate the mechanisms of cytotoxic activity and pro-/antioxidant effect of lactoferrin on hormone receptor-positive and receptor-negative breast cancer cells in vitro. Materials and Methods: The study was ...
Innovative policy of european institutes in solving cancer problems. The General Assembly of OECI, Genoa, Italy, May 21–24

Chekhun, V.F. (Experimental Oncology, 2008)

The General Assembly and Scientific week of OECI (Organization of European Cancer Institutes) took place in Genoa (Italy) on 21–24 of May. The membership of OECI comprises 58 European cancer institutions, including R.E. ...
In vitro modification of cisplatin cytotoxicity with magnetic fluid

Chekhun, V.F.; Yurchenko, O.V.; Naleskina, L.A.; Demash, D.V.; Lukianova, N.Yu.; Lozovska, Yu.V. (Experimental Oncology, 2013)

Aim: To study cytotoxicity of cisplatin conjugated with magnetic fluid (nanocomposite) upon exposure to magnetic field on sensitive and resistant to cisplatin MCF-7 human breast cancer cells. Methods: Cytotoxic activity ...
Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease

Naleskina, L.A.; Lukianova, N.Yu.; Sobchenko, S.O.; Storchai, D.M.; Chekhun, V.F. (Experimental Oncology, 2016)

Aim: To determine the patterns of lactoferrin (LF) expression in breast cancer (BC) in relation to biologic properties of the neoplasms and clinical features of the disease course. Materials and Methods: Clinical specimens ...
Metabolic changes during development of Walker-256 carcinosarcoma resistance to doxorubicin

Todor, I.N.; Lukianova, N.Yu.; Shvets, Yu.V.; Lozovska, Yu.V.; Chekhun, V.F. (Experimental Oncology, 2015)

Aim: To study indices of energy metabolism, content of K+ and Mg++ both in peripheral blood and in Walker-256 carcinosarcoma during development of resistance to doxorubicin. Methods: Resistance of Walker-256 carcinosarcoma ...
MicroRNAs in normal and cancer cells: a new class of gene expression regulators

Bagnyukova, T.V.; Pogribny, I.P.; Chekhun, V.F. (2006)

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at posttranscriptional level. They are involved in cellular development, differentiation, proliferation and apoptosis and play a significant ...
Modifying effects of 5-azacytidine on metal-containing proteins profile in guerin carcinoma with different sensitivity to cytostatics

Chekhun, V.F.; Lozovska, Y.V.; Naleskina, L.A.; Borikun, T.V.; Burlaka, A.P.; Todor, I.N.; Demash, D.V.; Yalovenko, T.M.; Zadvornyi, T.V.; Pavlova, A.O.; Storchay, D.M.; Lukianova, N.Yu. (Experimental Oncology, 2016)

Aim: To assess the influence of the treatment with 5-azacytidine (5-aza) on the profile of metal-containing proteins and factors of their regulation in Guerin carcinoma cells in vivo. Materials and Methods: The study was ...
Modifying effects of lactoferrin in vitro on molecular phenotype of human breast cancer cells

Chekhun, V.F.; Zalutskii, I.V.; Naleskina, L.A.; Lukianova, N.Yu.; Yalovenko, T.M.; Borikun, T.V.; Sobchenko, S.O.; Semak, I.V.; Lukashevich, V.S. (Experimental Oncology, 2015)

Aim: To assess the role of endogenous lactoferrin (LF) in the formation of the molecular phenotype of human breast cancer (BC) cell lines with varying degrees of malignancy, including cisplatin/doxorubicin resistant cell ...
Molecular-genetic models for prognosis of development of tumors of reproductive system in women with family history of cancer

Paliychuk, O.V.; Polishchuk, L.Z.; Rossokha, Z.I.; Chekhun, V.F. (Experimental Oncology, 2018)

Aim: To develop a prognostic molecular genetic model for assessing the risk of development of benign and malignant tumors of female reproductive organs (FRO) in patients from cancer-affected families. Patients and Methods: ...
Molecular profile and cell cycle in MCF-7 and MCF‑7/Dox cells exposed to conventional and liposomal forms of doxorubicin

Rusetskaya, N.V.; Lukyanova, N.Yu.; Chekhun, V.F. (Experimental Oncology, 2009)

Aim: To compare the molecular profile and cell cycle of sensitive and resistant to doxorubicin MCF-7 breast cancer cells upon exposition to conventional or liposome-encapsulated forms of doxorubicin. Methods: МТТ-test, ...
Molecular profile and cell cycle in mcf-7 cells resistant to cisplatin and doxorubicin

Lukyanova, N.Yu.; Rusetskya, N.V.; Tregubova, N.A.; Chekhun, V.F. (Experimental Oncology, 2009)

Aim: To compare ultrastructure, phenotypic profile and cell cycle progression ofMCF-7 human breast cancer cells and MCF7 sublines resistant to cisplatin (MCF-7/DDP) and doxorubicin (MCF-7/DOX). Methods: MTT-test, ...
Molecular profile of gastric cancer as a basis of individualized treatment and prognosis of disease outcome

Demash, D.V.; Bazas, V.M.; Lukianova, N.Yu; Rozumiy, D.O.; Chekhun, V.F. (Experimental Oncology, 2011)
Morphological features of doxorubicin-resistant Walker 256 carcinosarcoma and response of mast cells

Boroday, N.V.; Chekhun, V.F. (Experimental Oncology, 2018)

Background: The mechanisms of drug resistance of cancer have not been yet elucidated in details. Recently, the role of mast cells (MCs) in the development of drug resistance has been brought in the limelight. The aim of ...
Nanocomposites of medicobiologic destination: reality and perspectives for oncology. Review

Gorbyk, P.P.; Chekhun, V.F. (Functional Materials, 2012)

Analysis is given of the ways of creation of polyfunctional medicobiologic nanocomposites with multilevel hierarchic architecture that would be applicable for recognition of microbiological objects in biologic media, ...

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