Cardiovascular disease (CVD) in women is the most common cause of death and in 2009 accounted for one third of all deaths. The purpose of this paper is to present what conditions during pregnancy and during the pre-menopause ...

Emergence of castration-resistant metastatic prostate cancer is due to activation of survival pathways, including apoptosis suppression and anoikis resistance, and increased neovascularization. Thus targeting of apoptotic ...

Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a master anti-apoptotic regulator and resistance factor that suppresses tumor necrosis factor-α (TNF-α), Fas-L, and TNF-related apoptosis-inducing ...

Worldwide, breast cancer in women remains to be the most common malignancy that in a considerable proportion shows the resistance to genotoxic treatments and poor outcome. Chromosomal instability manifested as aneuploidy ...

Among the long-term effects of the Chornobyl disaster the greatest concern of international medical and scientific community is given to the established fact of excess of the spontaneous level of cancer incidence in the ...

Substantial evidence supports an association between periodontal disease and several systemic diseases including cardiovascular diseases, diabetes mellitus, respiratory diseases, adverse pregnancy outcomes, osteoporosis ...

In mammalian cells, the mitochondrial pathway of apoptosis plays a key role in various biological processes and has been extensively studied. One of the signature features of this pathway is permeabilization of the outer ...

В последнее время становится все более очевидным, что пространственная организация эукариотического генома играет важную роль в регуляции экспрессии генов. Трехмерную (3D) организацию генома можно исследовать с помощью ...

Aim: To study and compare the expression patterns of mucins in the fetal gastroesophageal junction (GEJ) region and adenocarcinomas of the GEJ in adults using histochemical method. Material and Methods: To reveal the ...

Aim. To review mechanisms of regulation of expression and the functionality of two isoforms of translation elongation factor eEF1A in mammalian cells. Results. eEF1A1 and eEF1A2 proteins are regulated by post-translational ...