Перегляд за темою "Genomics, Transcriptomics and Proteomics"

Результати 21-40 з 42

Heterogeneity of premetastatic niches gene expression in breast cancer cells

Tashireva, L.A.; Denisov, E.V.; Savelieva, O.E.; Geraschenko, T.S.; Zavyalova, M.V.; Perelmuter, V.M. (Вiopolymers and Cell, 2015)

Aim. To investigate the expression of the genes TGFB1, TNF, CSF1, CSF2, VEGFA and HIF1A in the patients with invasive breast carcinoma of no special type considering the intratumoral morphological heterogeneity. Methods. ...
Identification of rye chromosomes by flow cytogenetics

Alkhimova, O.G.; Zimina, O.V. (Вiopolymers and Cell, 2017)

The karyotype of the cultivated rye (Secale cereale) is one of the complex plant genomes whose chromosomes are difficult to discriminate because of their similar size. Aim. The purpose of this study is to reveal the ...
Implementation of the quantitative Real-Time PCR for the molecular-genetic diagnostics of spinal muscular atrophy

Soloviov, O.O.; Livshits, G.B.; Podlesnaya, S.S.; Livshits, L.A. (Вiopolymers and Cell, 2010)

Aim. To develop an easy and reliable assay for quantitative analysis of the SMN1 gene exon 7 copy number with Real-Time PCR and a SYBR Green dye which can be used as a test-system for spinal muscular atrophy (SMA) diagnostics. ...
Influence of EMAP II, IFN-α2b and its medicinal preparations on the MGMT protein amount in human cells in vitro

Kotsarenko, K.V.; Lylo, V.V.; Ruban, T.P.; Macewicz, L.L.; Kornelyuk, A.I.; Chernykh, S.I.; Lukash, L.L. (Вiopolymers and Cell, 2014)

Aim. To study the effect of EMAP II, IFN-α2b and its medicinal preparations on the amount of O6-methylguanine-DNA methyltransferase (MGMT) protein in human cells in vitro. Methods. The human cells of 4BL and Hep-2 lines ...
Influence of exogenous phytohormones, methyl jasmonate and suppressors of jasmonate biosynthesis on Agrobacterium-mediated transient expression in Nicotiana excelsior

Sindarovska, Y.R.; Gerasymenko, I.M.; Kuchuk, M.V.; Sheludko, Y.V. (Вiopolymers and Cell, 2012)

Our aim was to investigate the influence of some exogenous agents on the recombinant protein accumulation in plants via Agrobacterium-mediated transient expression. Methods. Agrobacterium-mediated transient expression ...
Interaction of ubiquitin ligase CBL with LMP2A protein of Epstein-Barr virus occurs via PTB domain of CBL and does not depend on adaptor ITSN1

Dergai, O.V.; Dergai, M.V.; Gudkova, D.O.; Tsyba, L.O.; Skrypkina, I.Ya.; Rynditch, A.V. (Вiopolymers and Cell, 2013)

Aim. Previously Latent membrane protein 2A (LMP2A) of Epstein-Barr virus was found to be ubiquitylated by CBL ubiquitin ligase but no direct interaction of LMP2A with CBL was reported. We aimed to explore this interaction ...
Isoforms of elongation factor eEF1A may be differently regulated at post-transcriptional level in breast cancer progression

Vislovukh, A.A.; Naumovets, M.G.; Kovalenko, M.I.; Groisman, R.S.; Groisman, I.S.; Negrutskii, B.S.; El'skaya, A.V. (Вiopolymers and Cell, 2013)

Eukaryotic translation elongation factor 1A exists as two 98 % homologous isoforms: eEF1A1 (A1) and eEF1A2 (A2) which are tissue and development specific. Despite high homology in an open reading frame (ORF) region, mRNAs ...
Low-density microarray analysis of TGFβ1-dependent cell cycle regulation in human breast adenocarcinoma MCF7 cell line

Dubrovska, A.M.; Souchelnytskyi, S.S. (Вiopolymers and Cell, 2014)

Transforming growth factor β1 (TGFβ1) is a growth regulator that has antiproliferative effects on a range of epithelial cells at the early stages and promoting tumorigenesis at the later stages of cancer progression. The ...
Mesenchymal and trophoblast immunophenotype of multipotent stromal cells from human placenta

Shablii, V.A.; Kuchma, M.D.; Kyryk, V.M.; Svitina, H.M.; Shablii, Yu.M.; Lukash, L.L.; Lobintseva, G.S. (Вiopolymers and Cell, 2014)

The investigation of trophoblast markers expression in the mesenchymal stromal cells of placental tissue before and after their isolation and cultivation. Methods. Placental multipotent mesenchymal stromal cells (MMSC) ...
Mice with pituitary tumor transforming gene (pttg) knockout demonstrate increased urinary space in renal corpuscles

Varyvoda, O.Yu.; Yashchenko, A.M.; Lutsyk, A.D.; Bilyy, R.O.; Afanasiev, S.V.; Filyak, Ye.Z.; Stoika, R.S. (Вiopolymers and Cell, 2014)

Aim. To investigate the effect of knockout of the pituitary tumor transforming gene (pttg-1) on the morphometric parameters and carbohydrate determinants of the murine renal structures. Methods. Kidneys of the knockout ...
Mitochondria do not play a major role in landomycin E-induced ROS burst and circumvention of multiple drug resistance in HL-60 leukemia cells

Panchuk, R.R.; Lehka, L.V.; Rohr, J.; Berger, W.; Stoika, R.S. (Вiopolymers and Cell, 2016)

Aim. To study the molecular mechanisms of reactive oxygen species (ROS) involvement in circumventing the cancer drug resistance by novel angucycline antibiotic landomycin E in HL-60 human leukemia cells and its drug-resistant ...
NGS-based identification of druggable alterations and signaling pathways – hepatocellular carcinoma case report

Kotelnikova, E.A.; Logacheva, M.D.; Nabieva, E.R.; Pyatnitskiy, M.A.; Vinogradov, D.V.; Makarova, A.S.; Demin, A.V.; Paleeva, A.G.; Kremenetskaya, O.S.; Penin, A.A.; Klepikova, A.V.; Kasianov, A.S.; Shavochkina, D.A.; Kudashkin, N.E.; Patyutko, Yu.I.; Mugue, N.S.; Kondrashov, A.S.; Lazarevich, N.L (Вiopolymers and Cell, 2015)

Aim. To identify potential cancer driving or clinically relevant molecular events for a patient with hepatocellular carcinoma. Methods. In order to achieve this goal, we performed RNA-seq and exome sequencing for the tumor ...
Phylogenetic analysis of Ukrainian seed-transmitted isolate of Soybean mosaic virus

Mishchenko, L.T.; Dunich, A.A.; Shcherbatenko, I.S. (Вiopolymers and Cell, 2018)

Soybean mosaic virus (SMV) is seed transmitted and can cause significant reductions in the yield and seed quality in soybean (Glycine max). The seed transmission rate of different SMV isolates is 0–43 %. The question ...
Sensitivity of Saccharomyces cerevisiae defective in TOR signaling pathway to carbonyl/oxidative stress

Valishkevych, B.V. (Вiopolymers and Cell, 2014)

Aim. To investigate the influence of carbonyl/oxidative stress induced by glyoxal, methylglyoxal and hydrogen peroxide on the survival of Saccharomyces cerevisiae, defective for different parts of TOR- signaling pathway, ...
Transcriptional and post-transcriptional control of eEF1A2 expression during myoblast diffrerentiation

Vislovukh, A.A.; Groisman, I.S.; El’skaya, A.V.; Negrutskii, B.S.; Polesskaya, A.N. (Вiopolymers and Cell, 2012)

During postnatal development, the switch of the expression from isoform A1 to the isoform A2 of eukaryotic translation elongation factor (eEF1A) is observed in neuronal and muscle tissues. The switch of the expression is ...
Transcriptional and posttranscriptional regulation of the adaptor/scaffold protein gene ITSN1

Kropyvko, S.V.; Gubar, O.S.; Gryaznova, T.A.; Morderer, D.Ye.; Gerasymchuk, D.O.; Syvak, L.A.; Grabovoy, A.N.; Rynditch, A.V. (Вiopolymers and Cell, 2016)

ITSN1 adaptor/scaffold protein takes part in a variety of physiological and pathological cellular processes. It has a complex expression regulation and many protein partners. Aim. Characterization of the ITSN1 functioning ...
Transcriptome-based identification of PDGFA as a candidate secreted biomarker for hepatocellular carcinoma

Chesnokov, M.S.; Krivtsova, O.M.; Skovorodnikova, P.A.; Makarova, A.S.; Kustova, I.F.; Logacheva, M.D.; Penin, A.A.; Klepikova, A.V.; Shavochkina, D.A.; Kudashkin, N.E.; Moroz, E.A.; Patyutko, Y.I.; Kotelnikova, E.A.; Lazarevich, N.L. (Вiopolymers and Cell, 2016)

Aim. Identification of candidate secreted biomarkers for hepatocellular carcinoma (HCC) diagnosis. Methods. Genes upregulated in HCC tissue and encoding secreted proteins were identified by RNA-seq. Gene expression changes ...
Алелі гена Ppd-D1 у зразках колекції Aegilops tauschii і м’якої пшениці

Чеботар, Г.О.; Чеботар, С.В.; Бабенко, Д.О.; Моцний, І.І.; Щербань, А.Б.; Cивола, Ю.М. (Вiopolymers and Cell, 2012)

Light period significantly influences on the growth and development of plants. One of the major genes of photoperiod sensitivity is Ppd-D1, located on the chromosome 2D. The aim of the work was to determine the alleles and ...
Генетическое разнообразие генофонда мягкой озимой пшеницы по аллелям связанного с морозоустойчивостью микросателлитного локуса Xgwm182-5D

Галаева, М.В.; Файт, В.И.; Сиволап, Ю.М. (Вiopolymers and Cell, 2013)

Цель. Идентификация сортов озимой мягкой пшеницы разных регионов по локусу Xgwm182-5D. Методы. Полимеразная цепная реакция, гель-електрофорез. Результаты. По аллелям локуса Xgwm182-5D идентифицированы генотипы 180 сортов ...
Експресія деяких генів, індукованих водним стресом, у проростках Аrabidopsis thaliana, вирощуваних за умов помірного водного дефициту

Бобровницький, Ю.А. (Вiopolymers and Cell, 2011)

Мета. Дослідити експресію деяких генів, індукованих водним стресом. Методи. Проростки вирощува - ли на агаризованому середовищі при повільно знижуваному водному потенціалі. Для визначення експресії генів використано метод ...

Результати 21-40 з 42

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Перегляд за темою "Genomics, Transcriptomics and Proteomics"

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